Trials / Conditions / Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

81 registered clinical trials studyying Locally Advanced Rectal Cancer — 29 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Short-Course RT Plus CAPOX and Tislelizumab vs Long-Course CRT Plus Tislelizumab for Locally Advanced Rectal C NCT07469306	Fujian Cancer Hospital	Phase 2
Not Yet Recruiting	ONCO-RET: Supervised Resistance Training During Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer NCT07453173	Fundacion Arturo Lopez Perez	N/A
Recruiting	A Single-arm Phase II Clinical Study of Camrelizumab Combined With Long-course Chemoradiotherapy for Total Neo NCT07527026	Chinese PLA General Hospital	Phase 2
Not Yet Recruiting	A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Re NCT07248020	Chang Gung Memorial Hospital	Phase 2
Recruiting	Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients NCT07514754	Fondazione del Piemonte per l'Oncologia	N/A
Recruiting	Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibi NCT07150949	Fudan University	Phase 2
Not Yet Recruiting	Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer NCT07074353	Zhejiang Cancer Hospital	Phase 3
Recruiting	Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Fiel NCT07057089	Hebei Medical University Fourth Hospital	Phase 2
Recruiting	Preoperative Chemoradiotherapy Combined With Consolidation or Induction NALIRIFOX in Rectal Cancer. NCT06894797	Peking University Cancer Hospital & Institute	N/A
Not Yet Recruiting	Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal Cancer NCT06760520	The First Affiliated Hospital of Zhengzhou University	Phase 2
Recruiting	Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cance NCT06802666	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Phase 2
Recruiting	GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients NCT07511413	Fondazione del Piemonte per l'Oncologia	—
Recruiting	MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer NCT06840665	Fudan University	Phase 2
Not Yet Recruiting	Correlation Between Gut Microbiota and Radiosensitivity of Rectal Cancer NCT06375434	Jing-kun Liu	—
Not Yet Recruiting	Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced M NCT06304987	Beijing Friendship Hospital	Phase 2
Recruiting	CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer NCT06281405	Fudan University	Phase 2
Recruiting	Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients Wit NCT06052332	Jules Bordet Institute	N/A
Recruiting	Node-sparing Radiotherapy Combined with Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal C NCT06204094	Jinhua Central Hospital	Phase 2
Active Not Recruiting	Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-l NCT06056804	Beijing Friendship Hospital	Phase 2
Recruiting	Preoperative Radiotherapy And ASTX660 in Rectum Cancer NCT05912075	Gustave Roussy, Cancer Campus, Grand Paris	Phase 1
Recruiting	Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant T NCT06234007	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Phase 2
Unknown	Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer NCT05980689	Sun Yat-sen University	Phase 2
Not Yet Recruiting	Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal Canc NCT05998122	The First Hospital of Jilin University	Phase 2
Not Yet Recruiting	Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK1 NCT05794750	JIN JING	Phase 2
Completed	Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer NCT06493240	Peking University People's Hospital	Phase 2
Recruiting	TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer NCT05646511	National Cancer Center Hospital East	Phase 3
Recruiting	SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer NCT05412082	University of Miami	Phase 1
Unknown	Total Neoadjuvant Therapy Combined With Tislelizumab for Local Advanced of Middle and Low Rectal Cancer NCT05845268	Beijing Friendship Hospital	Phase 2
Not Yet Recruiting	TIME in Immunotherapy Combined With nCRT for Rectal Cancer NCT05507112	Peking Union Medical College Hospital	Phase 2
Recruiting	SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer NCT05300269	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	Phase 2
Active Not Recruiting	Intraoperative Electron Radiotherapy in Rectal Cancer - A Feasibility Trial NCT05877352	University Hospital Southampton NHS Foundation Trust	N/A
Recruiting	Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer NCT05245474	Beijing Friendship Hospital	Phase 2
Active Not Recruiting	Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29 NCT05253846	Gruppo Oncologico del Nord-Ovest	Phase 2
Unknown	Gut Microbiome and Its Immune Modulation in Locally Advanced Rectal Cancer NCT05079503	Korean Cancer Study Group	N/A
Unknown	PelvEx 4: Advanced Pelvic Malignancy and the Role of the Multi-disciplinary Team Meeting NCT05076305	St Vincent's University Hospital, Ireland	—
Unknown	Dendrobium Huoshanense Suppository in Rectal Cancer NCT05079438	Zhejiang Cancer Hospital	Phase 3
Completed	Short-course Radiotherapy Followed by Tislelizumab + CapeOX in the Treatment for Locally Advanced Rectal Cance NCT05086627	Hebei Medical University Fourth Hospital	Phase 2
Unknown	A Contemporary Review of Surgical Approaches in Pelvic Exenterative Surgery NCT04948762	St Vincent's University Hospital, Ireland	—
Unknown	Fruquintinib Plus PD-1 Antibody in pMMR / MSS Locally Advanced Rectal Cancer (LARC) With High Immune Score NCT04989855	Sun Yat-sen University	Phase 2
Recruiting	Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for R NCT05054959	Institute of Oncology Ljubljana	Phase 2
Active Not Recruiting	Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer NCT04906044	The First Hospital of Jilin University	Phase 1
Completed	Short-course Radiotherapy Based TNT Combined With PD-1 Inhibitor for Locally Advanced Rectal Cancer NCT04518280	Fudan University	Phase 2
Unknown	THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy NCT04815694	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	N/A
Unknown	Development of a Genome-based Platform for Personalized Treatment in Locally Advanced Rectal Cancer Patients NCT04738214	Yonsei University	—
Unknown	Neoadjuvant Short-course Radiotherapy Followed by the Combination of Immunotherapy and Chemotherapy in Locally NCT04663763	Zhejiang Cancer Hospital	Phase 2
Unknown	The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSI-H Locally Advanced Rectal Cancer NCT04411524	Fudan University	Phase 2
Unknown	The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSS Locally Advanced Rectal Cancer NCT04411537	Fudan University	Phase 2
Unknown	A Trial of Neoadjuvant mFOLFOXIRI Versus CRT in the EMVI Positive LARC NCT04423965	First Affiliated Hospital of Zhejiang University	Phase 2
Unknown	A Study of Chinese Herbal Compound Dendrobium Huoshanense Granules in NCRT for Patients With Locally Advanced NCT04394598	Fudan University	Phase 2
Terminated	Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC NCT04177602	Universitätsklinikum Hamburg-Eppendorf	Phase 1 / Phase 2
Completed	Inflammation After Laparoscopic Robot-assisted Surgery for Locally Advanced Rectal Cancer NCT04324567	Oslo University Hospital	—
Completed	Chemoradiation With Enadenotucirev as a Radiosensitiser in Locally Advanced Rectal Cancer NCT03916510	University of Oxford	Phase 1
Completed	Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer NCT03770689	EMD Serono Research & Development Institute, Inc.	Phase 1 / Phase 2
Unknown	Evaluation of Efficacy, Quality of Life and Cost Effectiveness of Short-course Radiotherapy Followed by Capeci NCT03676517	Yonsei University	N/A
Unknown	Neoadjuvant mFOLFOXIRI Chemotherapy Alone for Extramural Vascular Invasion Positive Locally Advanced Rectal Ca NCT04170530	First Affiliated Hospital of Zhejiang University	Phase 2
Unknown	UGT1A1 Combined With Pharmacokinetics of SN-38 in CPT-11-based CRT in Patients With Advanced Rectal Cancer NCT03824899	Fudan University	N/A
Terminated	Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Pa NCT03699410	Dimitri Christoforidis	—
Unknown	Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma NCT03503630	Ali Shamseddine	Phase 2
Unknown	Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer NCT03702985	Fudan University	Phase 2
Recruiting	Organ Preservation in Locally Advanced Rectal Cancer NCT03064646	Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana	N/A
Unknown	Endoscopic Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer NCT03040180	Zealand University Hospital	Phase 2
Completed	Detection and Inflammatory Characterization of Deep Infection After Surgery for Locally Advanced Rectal Cancer NCT03392584	Oslo University Hospital	—
Unknown	Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Canc NCT02964468	Grupo de Investigación Clínica en Oncología Radioterapia	N/A
Completed	Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer NCT03443661	Aiping Zhou	Phase 2
Completed	Trial of Capecitabine With or Without Irinotecan Driven by UGT1A1 NCT02605265	Fudan University	Phase 3
Completed	Constructing a Multimodal Imaging System to Predict the Risk of Heterochronous Metastasis of Rectal Cancer NCT06293612	Cancer Institute and Hospital, Chinese Academy of Medical Sciences	—
Unknown	Rectal Cancer, Adjuvant Chemotherapy, FOLFOX(5-fluorouracil/Leucovorin/Oxaliplatin), Total Mesorectal Excision NCT02167321	Yonsei University	Phase 2
Terminated	Efficacy of NeoThermo-Radio-chemotherapy for LA Rectal Cancer Before Laparoscopic TME: Prospective Phase II Tr NCT02290574	Samsung Medical Center	N/A
Terminated	Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer NCT02151019	Cancer Trials Ireland	Phase 1 / Phase 2
Unknown	Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics A NCT03149978	Zhu Ji	—
Unknown	Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer NCT01899118	Zhejiang Cancer Hospital	Phase 2
Completed	Predicting Pathological Complete Response of Rectal Cancer With Magnetic Resonance(MR) Radiomics NCT03238885	Sun Ying-Shi	—
Completed	Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer NCT02353858	University Hospital Tuebingen	Phase 2
Completed	A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Ca NCT01589419	AbbVie (prior sponsor, Abbott)	Phase 1
Completed	The Effect of Cancer Therapies and Exercise on Mitochondrial Energetics and Fitness NCT01859442	Michelle Mossa	EARLY_Phase 1
Unknown	Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanc NCT03034473	University Medical Center Goettingen	N/A
Completed	Evaluation of Inflammatory Markers in LARC Patients NCT05893667	Hospital Pedro Hispano	—
Completed	Minimal Invasive Strategies for Good and Complete Response to Chemoradiation in Rectal Cancer NCT00939666	Maastricht University Medical Center	N/A
Completed	Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Recta NCT00828672	Universitaire Ziekenhuizen KU Leuven	Phase 2
Unknown	Preoperative Radiotherapy With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer: CRAB Phase II S NCT00842686	Institute of Oncology Ljubljana	Phase 2
Completed	Trial of Celecoxib With Preoperative Chemo- Radiation for Locally Advanced Rectal Cancer NCT00931203	National Health Research Institutes, Taiwan	Phase 2