NCT03238885

Predicting Pathological Complete Response of Rectal Cancer With Magnetic Resonance(MR) Radiomics

Predicting Pathological Complete Response of Rectal Cancer to Neoadjuvant Chemoradiotherapy With MR Radiomics Method

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 538 (actual)
• Sponsor: Sun Ying-Shi · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study plans to construct a MR radiomics model for predicting pathological complete response(pCR) to neoadjuvant chemoradiotherapy(CRT) in locally advanced rectal cancer(LARC) patients.

Detailed description

We propose to develop and validate a radiomics model for individualized pCR evaluation after CRT in patients with LARC. We plan to use both pre- and post-CRT MRI data to construct the predictive radiomics model for evaluating if LARC patients achieve pCR after CRT. The ultimate aim is to select appropriate LARC patients for omission of surgery.

Conditions

• Locally Advanced Rectal Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	pelvic MR examination	All patients will take pelvic MR examination within 1 week before CRT and within 1 week before surgery.Pre- and post-CRT MRI examinations will be performed using a 3.0 T unit (Discovery 750) using an 8-channel phased array body coil in the supine position. To reduce colonic motility, 20mg of scopolamine butylbromide will be injected intramuscularly 30 min before MRI.

Timeline

• Start date: 2013-03-01
• Primary completion: 2018-12-18
• Completion: 2019-01-21
• First posted: 2017-08-03
• Last updated: 2019-02-04

Locations

1 site across 1 country: China