| Recruiting | AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anest NCT07449884 | Saint-Joseph University | N/A |
| Not Yet Recruiting | Lavender vs Bitter Orange Aromatherapy to Reduce Anxiety and Pain in Pediatric Local Anesthesia NCT07367594 | October University for Modern Sciences and Arts | N/A |
| Recruiting | Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients NCT07133919 | Çanakkale Onsekiz Mart University | N/A |
| Not Yet Recruiting | Hysteroscopy Anesthesia for Relief of Pain NCT07178379 | Maimónides Biomedical Research Institute of Córdoba | N/A |
| Withdrawn | Influence of Standardized Perioperative Anesthetic, Analgesic Care on Outcome of Patients Undergoing Hip Fract NCT06925789 | Milton S. Hershey Medical Center | Phase 1 |
| Recruiting | Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial NCT07130760 | Aula Dental Avanzada | N/A |
| Not Yet Recruiting | RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients NCT06969118 | Shanghai Zhongshan Hospital | N/A |
| Completed | Comparison of Computer-Assisted and Conventional Local Anesthesia Methods in Mandibular Impacted Third Molar S NCT06852066 | Afyonkarahisar Health Sciences University | N/A |
| Enrolling By Invitation | Effect of AV Distraction and Acuapoint Stimulation in Pediatric Extraction on Pain and Anxiety NCT07371442 | Mansoura University | N/A |
| Not Yet Recruiting | Result Of Use Of Wide Awake Local Anaesthesia In Fixation Of Ankle Fractures NCT06395987 | Assiut University | — |
| Recruiting | Comparison of Anesthetic Efficacy and Safety Between Nerve Block and Infiltrative Technique for Mandibular Pos NCT06641232 | University of Barcelona | N/A |
| Not Yet Recruiting | Can Caudal Dexmedetomidine Provide Effective Analgesia? NCT05902780 | Benha University | N/A |
| Recruiting | Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation. NCT06346132 | Schlotterbeck Hervé | N/A |
| Unknown | Efficacy of EMLA Cream Assisted Loco-sedation for Office-based Andrology Procedures NCT06242977 | University of Manitoba | Phase 3 |
| Completed | Effect of Pre-Warming of Local Anesthesia in Reducing Pain Perception During Injection in Children NCT06519838 | Andrew Emad | N/A |
| Unknown | Pain Perception Comparison of Computerized vs Conventional Injection Methods NCT06129162 | Mansoura University | N/A |
| Completed | Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulb NCT06501352 | Ain Shams University | EARLY_Phase 1 |
| Completed | Buffered Anesthetic Solution in the Treatment of Mandibular Primary Molars NCT05793905 | Damascus University | Phase 4 |
| Completed | Dental Anxiety and Pain During Inferior Alveolar Nerve Block in Children: the Effects of Two Distraction Techn NCT06788301 | Pamukkale University | N/A |
| Unknown | Effectiveness of Sodium Bicarbonate Buffered Anaesthetic Solution on Pain During Injection NCT05473819 | Alexandria University | N/A |
| Completed | Effect of a Candy Flavoring Before Local Anesthesia on Anxiety and Pain Perception in Children NCT05727527 | King Abdullah University Hospital | N/A |
| Completed | The Effect of Needle-free Injection System During Palatal Anesthesia NCT05166291 | Okan University | N/A |
| Completed | Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L in Children NCT04477317 | Cairo University | Phase 3 |
| Completed | Clinical Efficiency of Xanthan Hydrogels Containing Local Anesthetics Encapsulated in Nanostructured Lipid Car NCT05912335 | University of Campinas, Brazil | Phase 1 |
| Unknown | Quadratus Lumborum Block as an Anesthetic Method for Percutaneous Nephrolithotomy NCT04852874 | Al-Azhar University | N/A |
| Unknown | Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine by Laypersons NCT04733781 | Jeffrey Alan Klein, MD | Phase 2 / Phase 3 |
| Completed | Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patie NCT04633850 | Jannie Bisgaard Stæhr | — |
| Completed | Topical Lidocaine Anesthesia for Nasopharyngeal Sampling NCT04885777 | Ataturk University | N/A |
| Recruiting | The Effect of Music Therapy Under Ultrasound Guided Manual Vacuum Aspiration NCT04708808 | Chinese University of Hong Kong | N/A |
| Completed | Pain Relief During Intravenous Cannulation in Pediatric Patients NCT04246255 | Yeditepe University | Phase 4 |
| Unknown | PECS Block in Partial Mastectomy for Postoperative Pain Control NCT04086394 | Main Line Health | N/A |
| Completed | Is Masseteric Nerve Block Effective in Myofascial Pain NCT04339673 | Erzincan University | N/A |
| Completed | Pre-emptive Analgesic Administration in Primary Tooth Extraction NCT03786029 | Tishreen University | Phase 2 / Phase 3 |
| Completed | Pain Perception of Needle-free System NCT04653974 | Tokat Gaziosmanpasa University | N/A |
| Completed | Efficacy of Virtual Reality in Reducing Injection Pain and Anxiety During Local Anesthesia in Children NCT03772483 | Plovdiv Medical University | N/A |
| Withdrawn | Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment NCT03502135 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | Local Anesthesia With Needle-free Injection System NCT04028271 | Sinem yildirim | N/A |
| Completed | To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor NCT04947267 | Afshan Amjad Ali | Phase 2 |
| Completed | A Study of a New Local Anesthesia Method for Transperineal Prostate Biopsy NCT03500432 | Second Military Medical University | N/A |
| Completed | Pain and Anxiety Evaluation in Children Using Different Techniques of Local Anesthesia for Dental Treatment NCT03176446 | Universidade Estadual de Ponta Grossa | N/A |
| Withdrawn | Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar N NCT03225326 | University of Belgrade | Phase 4 |
| Completed | Impact of Music Intervention on Pain Control In First Trimester Surgical Abortion Under Local Anesthesia NCT02922504 | University Hospital, Angers | N/A |
| Completed | Effect of Lidocaine With Magnesium Sulfate on the Success of the Inferior Alveolar Nerve Block NCT03262857 | Isfahan University of Medical Sciences | Phase 2 |
| Completed | Effect of Lidocaine/Dexamethasone on the Success of IANB NCT03531970 | Isfahan University of Medical Sciences | Phase 2 / Phase 3 |
| Terminated | Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia NCT02647892 | University of Nebraska | Phase 4 |
| Unknown | The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesi NCT02535273 | Tang-Du Hospital | Phase 4 |
| Completed | Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty. NCT02793986 | The First Affiliated Hospital of Anhui Medical University | N/A |
| Terminated | To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo NCT02584335 | Hospital Universitari de Bellvitge | Phase 4 |
| Completed | Success of Inferior Alveolar Nerve Block in Women Taking Selective Serotonin Reuptake Inhibitors NCT02884596 | Isfahan University of Medical Sciences | — |
| Completed | Intermediate Cervical Block Under Ultrasound for Thyroid Surgery: Impact on Per and Postoperative Opioid Consu NCT03107585 | University Hospital, Mahdia | N/A |
| Completed | Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block NCT02726737 | Masoud Saatchi | Phase 3 |
| Completed | Remifentanil And Local Anesthesia Compared With Local Anesthesia For The Insertion Of Central Venous Catheters NCT02206022 | University Hospital, Toulouse | Phase 4 |
| Unknown | Evaluation of Deep Topical Fornix Nerve Block Versus Topical Anaesthesia Procedure NCT02196441 | Cairo University | N/A |
| Completed | Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar N NCT02440347 | University of Belgrade | Phase 4 |
| Completed | Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2 NCT02371759 | University of Belgrade | Phase 3 |
| Completed | Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpiti NCT02226913 | Masoud Saatchi | Phase 3 |
| Completed | A Prospective Randomized Trial of Two Different Prostate Biopsy Schemes NCT02825225 | University of Nove de Julho | N/A |
| Terminated | Comparing Ilioinguinal Single-shot and Three-layer Blocks NCT01625780 | University of Alberta | N/A |
| Terminated | Catheter-over-needle: Inpatient Study NCT01522053 | University of Alberta | N/A |
| Terminated | Catheter-over Needle: Outpatient Study NCT01522066 | University of Alberta | N/A |
| Completed | Efficacy and Safety of Lambdalina (Lidocaine Cream) Versus Placebo as an Anesthetic for Laser Hair Removal NCT01360749 | ISDIN | Phase 2 |
| Completed | EMLA Topical Anesthetic During Scaling and Root Planing NCT01860235 | Franciscan University Center | N/A |
| Completed | Local Anaesthesia Used During Fast-track Colonic Surgery: Evaluation of Bupivacaine and Levobupivacaine in Pra NCT01105442 | Martini Hospital Groningen | — |
| Completed | Safety and Efficacy Study of an Iontophoretic Patch Containing Lidocaine and Epinephrine for Venipuncture in H NCT00889642 | Dharma Therapeutics Inc. | Phase 2 |
| Completed | The Anesthetic Effect of Anterior Middle Superior Alveolar Technique NCT01742559 | State University of Maringá | N/A |
| Completed | A Study to Assess the Safety and Efficacy of a Microneedle Device for Local Anesthesia NCT00539084 | NanoPass Technologies Ltd | N/A |
| Completed | Comparison of Functional Bracing vs Rigid Immobilization After Modified Percutaneous Achilles Tendon Repair NCT04692883 | University Medical Centre Maribor | N/A |