Clinical Trials Directory

Trials / Completed

CompletedNCT04633850

Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients

Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients: A Before and After Study

Status
Completed
Phase
—
Study type
Observational
Enrollment
45 (actual)
Sponsor
Jannie Bisgaard Stæhr · Academic / Other
Sex
All
Age
18 Years
Healthy volunteers
Not accepted

Summary

To investigate the effect of intercostal blockade with and without adjuvants.

Detailed description

Video-assisted thoracoscopic surgery (VATS) is a minimally invasive routine procedure. It's less invasive than thoracotomy but postoperative pain is still a problem. At Aalborg University Hospital, intercostal blockades with bupivacaine is used as standard pain treatment for patients undergoing VATS. Adding adjuvants to the blockades may prolong the effect. The aim of this study is to investigate if intercostal nerve blockade with adjuvants (intravenous (IV) dexamethasone) will result in better pain management. The primary plan was to evaluate the effect of adding IV dexamethasone and perineural adrenaline, but due to adverse effects, adrenaline was first reduced and later removed from the intervention (amendment protocol N-20200040 approved by the Ethics Committee of Northern Jutland on February 2nd 2021).

Conditions

Interventions

TypeNameDescription
DRUGDexamethasoneIntravenous dexamethasone 8 mg. Given once at the end of surgery.
DRUGBupivacainBupivacaine dose according to weight. \<60 kg: Total dose 100mg 60-90kg: Total dose 150mg \>90kg: Total dose 200mg Given once at the end of surgery.

Timeline

Start date
2020-09-08
Primary completion
2021-04-28
Completion
2021-04-28
First posted
2020-11-18
Last updated
2021-07-01

Locations

1 site across 1 country: Denmark

Regulatory

Source: ClinicalTrials.gov record NCT04633850. Inclusion in this directory is not an endorsement.