| Not Yet Recruiting | Perceptions of De-implementing Routine Follow-ups After Hip and Knee Arthroplasty NCT07041528 | Tergooi Medical Center | — |
| Recruiting | Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Bloc NCT07526831 | TC Erciyes University | — |
| Not Yet Recruiting | Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty NCT07097493 | Wake Forest University Health Sciences | Phase 4 |
| Not Yet Recruiting | Impact of Exercise Access on Physio Outcomes Post Knee Replacement NCT07502040 | Hull University Teaching Hospitals NHS Trust | N/A |
| Not Yet Recruiting | Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Bl NCT07418307 | Zagazig University | N/A |
| Not Yet Recruiting | Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA NCT07430085 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Phase 4 |
| Recruiting | Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial) NCT07425457 | Attikon Hospital | N/A |
| Not Yet Recruiting | Comparison of ACB With ACB and BiFeS Combination in Knee Arthroplasty Surgeries NCT07233785 | Cumhuriyet University | N/A |
| Recruiting | Machine Learning for Predicting Spinal Anesthesia Duration NCT07256548 | Kocaeli City Hospital | — |
| Recruiting | Functional Impact at 12 Months Post-op of Posterior Cruciate Ligament Conservation During Robotic-assisted Sur NCT07489963 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Not Yet Recruiting | HAKA: Routine Follow-up at 10 Years After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthca NCT07070570 | Reinier Haga Orthopedisch Centrum | N/A |
| Recruiting | The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery NCT07089251 | King Abdullah International Medical Research Center | Phase 4 |
| Recruiting | HAKA: Routine Follow-Up at 1 Year After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthcare NCT06971757 | JointResearch | N/A |
| Recruiting | Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study NCT07110324 | Rigshospitalet, Denmark | — |
| Recruiting | Remote Monitoring After Total Knee Replacement NCT07003932 | Diakonhjemmet Hospital | N/A |
| Not Yet Recruiting | Physica TT Tibial Plate Prospective Study NCT06830603 | Limacorporate S.p.a | — |
| Active Not Recruiting | Combined Cyclic Compression Cryotherapy and Phased Rehabilitation Training for Recovery After Knee Replacement NCT07089212 | Qilu Hospital of Shandong University | N/A |
| Not Yet Recruiting | The Effect of Tele-Consultation Supported Education After Total Knee Arthroplasty Surgery NCT06784596 | Turgut Sohret | N/A |
| Completed | ROSA® Knee System V1.5 Pilot Study NCT07009912 | Zimmer Biomet | N/A |
| Recruiting | DIGITAL-KNEE Study: Adequately Diagnosing Total Knee Arthroplasty Loosening by Evaluating the AtMoves Knee Sys NCT06839807 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Recruiting | BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty NCT06746168 | Jessa Hospital | N/A |
| Recruiting | Effect of Artificial Intelligence-Assisted Motivational Talk on Patients' Fear of Movement and Mobility Level NCT06758297 | Kocaeli University | N/A |
| Recruiting | Maximal and Self-selected Walkingspeed After Knee Arthroplasty - a Prospective Cohort Study NCT06847113 | Lovisenberg Diakonale Hospital | — |
| Completed | Knee Replacement and Sarcopenia NCT06635356 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | — |
| Recruiting | Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan NCT06108063 | Steadman Philippon Research Institute | Phase 1 / Phase 2 |
| Recruiting | RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques NCT06389435 | Danderyd Hospital | N/A |
| Recruiting | CAS vs Standard Technique in TKA: Comparison of Clinical and Functional Results NCT06608745 | Istituto Ortopedico Rizzoli | N/A |
| Completed | Postoperative Analgesia in Bilateral Knee Arthroplasties NCT06357013 | Kocaeli City Hospital | — |
| Active Not Recruiting | Factor XI inhibiTion for the Prevention of Venous Thromboembolism in Patients Undergoing Total Knee Arthroplas NCT06180889 | Suzhou Alphamab Co., Ltd. | Phase 2 |
| Unknown | Action Observation Therapy Via Telerehabilitation on Total Knee Arthroplasty Surgery NCT06162208 | Pamukkale University | N/A |
| Enrolling By Invitation | Exactech Knee Systems Post Market Clinical Follow-up NCT07107581 | Exactech | — |
| Completed | The Use of the GRASP System for Postoperative Monitoring NCT06825988 | Haukeland University Hospital | EARLY_Phase 1 |
| Active Not Recruiting | Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty NCT05100706 | University of Toronto | N/A |
| Completed | The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties NCT07236073 | Ataturk University | N/A |
| Completed | Cementless Triathlon 5YR Follow-Up NCT05877261 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Recruiting | Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment NCT05516381 | Exactech | N/A |
| Completed | Randomized Controlled Trial Comparing Robotic-Assisted Versus Conventional Total Knee Arthroplasty NCT07212296 | Hospital de Terrassa | N/A |
| Unknown | Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing NCT04564729 | Brigham and Women's Hospital | N/A |
| Recruiting | Evaluation of Walking Analysis After a Total Knee Arthroplasty With Kinematic Alignment Versus Mechanical Alig NCT04226339 | Hospices Civils de Lyon | N/A |
| Completed | Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty NCT04090125 | University of North Carolina, Chapel Hill | N/A |
| Completed | Knee Body Perception and Pain After Total Knee Arthroplasty NCT07410884 | Prefectural University of Hiroshima | — |
| Completed | Gait Kinematics After Primary Total Knee Arthroplasty (TKA) Versus Revision TKA NCT03898544 | Hospices Civils de Lyon | — |
| Recruiting | A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System NCT05653102 | Exactech | — |
| Unknown | Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty NCT03695640 | Ufuk University | Phase 4 |
| Completed | The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA) NCT03703206 | University of Pennsylvania | Phase 3 |
| Completed | Surgical Approach in Fast Track Knee Arthroplasty NCT04450485 | Pamukkale University | N/A |
| Completed | Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial NCT02947321 | Vanderbilt University Medical Center | N/A |
| Terminated | Effectiveness of a Psychological Intervention in Patients Undergoing Total Knee Arthroplasty NCT02988947 | University of Minho | N/A |
| Completed | FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthropla NCT03276143 | Bayer | Phase 2 |
| Completed | Hypnosis for Symptom Management in Elective Orthopedic Surgery NCT03308071 | Stanford University | N/A |
| Terminated | Tourniquet Pressure in Primary Total Knee Arthroplasty NCT02830087 | Wake Forest University Health Sciences | N/A |
| Completed | Predictors and Outcomes of Intraoperative Hypothermia in Patients Undergoing Knee Arthroplasty NCT04575246 | Aga Khan University | — |
| Active Not Recruiting | LEGION Hinge Safety and Efficacy Study NCT02445443 | Smith & Nephew, Inc. | — |
| Completed | The Effect of Local Anesthetic Volume Within the Adductor Canal on Quadriceps Function Evaluated by Electromyo NCT02344589 | Ulrik Grevstad | Phase 4 |
| Completed | iTotal Pilot Study of ConforMIS Custom Total Knee Implant NCT02186587 | University of Missouri-Columbia | N/A |
| Completed | Ultrasound-guided Selective Blockade of the Saphenous and Obturator Nerves Following Total Knee Arthroplasty NCT02465827 | Bispebjerg Hospital | Phase 4 |
| Completed | Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty NCT03492320 | Dr. Ho Ki Wai | — |
| Completed | Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Dou NCT02327117 | Isfahan University of Medical Sciences | N/A |
| Active Not Recruiting | Optetrak Knee System Post Market Clinical Follow-Up NCT05788757 | Exactech | — |
| Completed | Manual Lymphatic Drainage Following Total Knee Arthroplasty Surgery NCT00711711 | Haute Ecole de Santé Vaud | N/A |
| Completed | Highly Cross-linked Polyethylene in Total Knee Arthroplasty NCT03622398 | Ewha Womans University | Phase 4 |
| Completed | Posterior Cruciate Retaining (PCR) Versus Posterior Cruciate Substituting (PCS) Total Knee Arthroplasty (TKA) NCT02429856 | University of Alberta | Phase 4 |