Trials / Recruiting
RecruitingNCT07089251
The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
- Status
- Recruiting
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- Sponsor
- King Abdullah International Medical Research Center · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty. Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration
Detailed description
Patients will be randomly divided into two groups: one receiving intravenous low-dose epinephrine and tranexamic acid, while the other will receive TXA alone as the control. Randomization to be done using a computer-generated table. The study will be done a superiority clinical trial. with an estimated 24 hour blood loss of 300 ml, with standard deviation of 150 ml. a power of 80% and alpha 5%, an estimated sample size of 80 is needed to detect a difference.
Conditions
- Knee Arthroplasty, Total
- Knee Arthritis, Osteoarthritis
- Total Knee Anthroplasty
- Blood Loss
- Tranexamic Acid Use
- Epinephrine
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | low-dose epinephrine and tranexamic acid | low-dose epinephrine and tranexamic acid |
| DRUG | Tranexamic Acid (TXA) treatment | Tranexamic Acid |
Timeline
- Start date
- 2025-07-15
- Primary completion
- 2027-06-24
- Completion
- 2027-06-24
- First posted
- 2025-07-28
- Last updated
- 2025-07-28
Locations
1 site across 1 country: Saudi Arabia
Source: ClinicalTrials.gov record NCT07089251. Inclusion in this directory is not an endorsement.