NCT06746168

BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty

Infiltration of Local Anesthetics Between the Popliteal Artery and Capsule of the Knee (iPACK) With Femoral Triangle Block (TFB) Versus Surgical Local Infiltration Analgesia (LIA) in Unilateral Total Knee Arthroplasty (TKA): A Multicenter Double-blind, Prospective Randomized Controlled Study.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 210 (estimated)
• Sponsor: Jessa Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to compare the anesthetic combination iPACK with femoral triangle block versus surgical LIA for unilateral TKA. We hypothesize that an iPACK block with femoral triangle block is non-inferior to surgical LIA. Furthermore, due to visualization of the relevant neural and vascular structures, the risk of accidental popliteal block, nerve damage or LAST with (a blindly performed) LIA could theoretically be reduced.

Conditions

• Knee Arthroplasty, Total

Interventions

Type	Name	Description
PROCEDURE	Locoregional anesthesia	The FTB + iPACK group will receive 12 ml 0,5% ropivacaine for the FTB and 20 ml of ropivacaine 0.5% for the iPACK block under US guidance after spinal anesthesia
PROCEDURE	Local Anesthetic Ropivacaine	The control group (LIA) will receive 120 ml 0.25% ropivacaine for surgical LIA placement.

Timeline

• Start date: 2025-01-09
• Primary completion: 2026-12-31
• Completion: 2027-11-30
• First posted: 2024-12-24
• Last updated: 2025-02-20

Locations

1 site across 1 country: Belgium