| Not Yet Recruiting | Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerot NCT07468448 | Population Health Research Institute | Phase 3 |
| Recruiting | Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis NCT07282041 | National University of Singapore | Phase 2 / Phase 3 |
| Recruiting | Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy in Symptomatic IC NCT06714526 | Sunnybrook Health Sciences Centre | N/A |
| Recruiting | PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis NCT06902740 | Peking Union Medical College Hospital | Phase 4 |
| Recruiting | IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS) NCT06472336 | University Hospital, Basel, Switzerland | N/A |
| Not Yet Recruiting | Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry) NCT06614972 | RenJi Hospital | — |
| Recruiting | ICAS Screen Based on RIC NCT06610578 | Xuanwu Hospital, Beijing | — |
| Not Yet Recruiting | Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study NCT06453252 | Sohag University | — |
| Not Yet Recruiting | Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery NCT06331494 | First Affiliated Hospital, Sun Yat-Sen University | N/A |
| Unknown | Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aIC NCT06080256 | The First Affiliated Hospital with Nanjing Medical University | Phase 3 |
| Unknown | Anticoagulation Using Rivaroxaban on Top of Aspirin in Intracranial Atherosclerotic Stenosis NCT05700266 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 / Phase 3 |
| Unknown | Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intrac NCT06058130 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Recruiting | The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Symptomatic Intracrania NCT05757505 | Ton-Bridge Medical Tech. Co., Ltd | N/A |
| Recruiting | High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic Stroke NCT05897645 | General Hospital of Shenyang Military Region | — |
| Unknown | Effects of Medical Treatment of ICAS With Hemodynamic Disorders Based on MR-FFR NCT06196398 | Xuanwu Hospital, Beijing | — |
| Unknown | The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Intracranial Atheroscle NCT05593224 | Ton-Bridge Medical Tech. Co., Ltd | N/A |
| Recruiting | Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Stu NCT06336174 | Anhui Medical University | — |
| Completed | A Study of Implantation of CRENEOUS ENTERPRISE 2 Intracranial Stent in Participants With Severe Symptomatic In NCT05316311 | Medos International SARL | N/A |
| Completed | Short- and Long-term Outcomes of Stenting for Symptomatic Intracranial Arterial Stenosis: a Cohort Study NCT05203887 | Sohag University | — |
| Completed | Elucidate Outcomes of Elective High-grade/Total Occlusion Intracranial Arteries Using Low-profile Self-expandi NCT05947994 | Can Tho Stroke International Services Hospital | N/A |
| Unknown | A Single-Arm Trial of Neurovascular Drug-Eluting Balloon Dilatation Catheter Treating Symptomatic Intracranial NCT04949880 | Zhejiang Zylox Medical Device Co., Ltd. | N/A |
| Active Not Recruiting | Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis NCT05001984 | Chang Gung Memorial Hospital | Phase 2 |
| Completed | AcoArt sICAS: DCB in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis NCT04631055 | Acotec Scientific Co., Ltd | N/A |
| Recruiting | ACOART Intracranial ISR Pilot:Intracranial DCB in the Treatment of Intracranial In-stent Restenosis NCT04627870 | Acotec Scientific Co., Ltd | N/A |
| Completed | Predicting Stroke Risk in ICAD With Novel MRI NCT05515874 | Northwestern University | Phase 4 |
| Recruiting | Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis NCT05550077 | jiaoliqun | — |
| Active Not Recruiting | Adding Antiplatelet During Edoxaban Treatment in Stroke Patients With Non-valvular Atrial Fibrillation (ADD-ON NCT04010955 | Asan Medical Center | — |
| Completed | Rescue Intracranial Stenting in Acute Ischemic Stroke NCT04986774 | Can Tho Stroke International Services Hospital | N/A |
| Completed | Diagnostic Accuracy for Hemodynamically ICAS of MR-FFR Comparing With Pressure-wire-based FFR. NCT05631470 | Xuanwu Hospital, Beijing | — |
| Completed | Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke NCT03990545 | University of Pennsylvania | — |
| Completed | Comparison of Cerebral Artery Pressure Gradient and Cerebral Blood Flow Measured by Arterial Spin Labeling NCT05623943 | Xuanwu Hospital, Beijing | — |
| Terminated | PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis NCT03507374 | University of Utah | EARLY_Phase 1 |
| Completed | Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis NCT03208166 | Medical University of South Carolina | N/A |
| Unknown | Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia NCT03105141 | Capital Medical University | Phase 2 / Phase 3 |
| Completed | Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI NCT03084523 | Yale University | Phase 1 |
| Unknown | Angioplasty and Stenting for Patients With Symptomatic Intracranial Atherosclerosis NCT02689037 | The 476th Hospital of People's Liberation Army | Phase 3 |
| Unknown | Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis NCT02719652 | Xiuhai Guo | — |
| Unknown | Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sIC NCT02534545 | Ji Xunming,MD,PhD | N/A |
| Completed | Post Market Surveillance Study of the Wingspan Stent System NCT02034058 | Stryker Neurovascular | N/A |
| Completed | Asymptomatic Intracranial Atherosclerotic Disease in Pakistanis NCT02072876 | Aga Khan University | — |
| Completed | Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis NCT01819597 | Cedars-Sinai Medical Center | N/A |
| Completed | Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft NCT01838356 | Yale University | — |
| Unknown | Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis NCT02458755 | Samsung Medical Center | Phase 4 |
| Completed | An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Sten NCT00929383 | Stryker Neurovascular | — |
| Unknown | Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China NCT00685308 | Ministry of Health, China | — |