Trials / Recruiting
RecruitingNCT05550077
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis: a Prospective Registry Study (OCT-ICAS)
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 400 (estimated)
- Sponsor
- jiaoliqun · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).
Detailed description
Stroke was the second leading cause of death worldwide and the leading cause of death in China in 2017. ICAS accounted for 10% to 15% of ischemic stroke in Western countries, and as much as 46.6%in Asia in 2009. For patients with ICAS, the risk of stroke is highly related to the histopathology of atheromatous plaques. Therefore, characterizing the morphology and composition of plaques in ICAS may help to predict the risk of stroke occurrence and allow the adoption of preventive or therapeutic management to prevent such life-threatening events. OCT, with a resolution of 10μm, may provide more reliable information in characterizing atheromatous plagues. This study aims to get a better insight into the value of OCT in evaluating the vessel wall structure and therefore guiding the interventional therapy of ICAS. In addition, the clinical and biological information will be included to achieve correlation analysis so as to get biomarkers subject to various plaque characteristics.
Conditions
- Intracranial Atherosclerosis
- Optical Coherence Tomography
- Plaque, Atherosclerotic
- Artery Stenosis
- Ischemic Stroke
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Optical Coherence Tomography | Intravascular evaluation for vessel wall structure of intracranial atherosclerotic stenosis by application of optical coherence tomography |
| PROCEDURE | Percutaneous transluminal angioplasty and stenting | Percutaneous transluminal angioplasty and stenting will be performed follow the standard or adjusted according to OCT evaluation. |
Timeline
- Start date
- 2020-03-15
- Primary completion
- 2026-12-31
- Completion
- 2027-12-31
- First posted
- 2022-09-22
- Last updated
- 2022-09-23
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT05550077. Inclusion in this directory is not an endorsement.