NCT06196398

Effects of Medical Treatment of ICAS With Hemodynamic Disorders Based on MR-FFR

Effects of Medical Treatment of Intracranial Atherosclerotic Diseases Based on Magnetic Resonance Fractional Flow Reserve

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Xuanwu Hospital, Beijing · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This multicenter prospective cohort study aims to compare the difference in the effects of medical treatment within 1 year between the two groups of ICAS patients divided hemodynamically by Magnetic Resonance Fractional Flow Reserve. PC MRA will be applied for FFR measurement. The primary outcome is the composite of ischemic stroke or death related to the qualifying artery territory for 1 year.

Conditions

• Stroke, Ischemic
• Intracranial Atherosclerosis

Interventions

Type	Name	Description
DRUG	Standard Medical Treatment on the basis of anti-platelet therapy	1. Anti-platelet therapy: aspirin 75mg+clopidogrel 100mg will be applied for patients with severe ICAS stenosis (70%-90%) suffering stroke or TIA within 30 days. After 90 days, single anti-platelet therapy will be continued. 2. Intensive statin therapy: Statins with high doses 3. Blood pressure: below 140/90mmHg 4. LDL: less than 1.81mmol/L(70mg/dl) 5. Fasting blood glucose controlled to 5.9mmol/L, and glycosylated hemoglobin A1c reduced to less than 7% 6. Cigarette and alcohol quitting 7. Oral anticoagulants for atrial fibrillation

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-06-01
• Completion: 2024-06-01
• First posted: 2024-01-09
• Last updated: 2024-01-09

Locations

1 site across 1 country: China