Trials / Unknown
UnknownNCT06058130
Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery Stenosis
Combination of Antiplatelet and Anticoagulation for Acute Ischemic Stroke Patients Witn Concomitant Non-valvular Atrial Fibrillation and Extracranial/Intracranial Artery Stenosis
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 2,171 (estimated)
- Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this clinical trial is to compare the safety and effectiveness of anticoagulation combined with antiplatelet therapy in acute ischemic stroke (AIS) patients with concomitant non-valvular atrial fibrillation (NVAF) and extracranial/intracranial artery stenosis. Participants will be 1:1 randomized into anticoagulation alone or anticoagulation combined with antiplatelet therapy. The primary endpoint is composite events 3 months after enrollment.
Detailed description
Concomitant NVAF and extracranial/intracranial artery stenosis will greatly increase the risk of stroke, even with standard anticoagulation. However, clinicians may be concerned with the high risk of bleeding complications of anticoagulation combined with antiplatelet therapy. The goal of this clinical trial is to evaluate the safety and effectiveness of anticoagulation combined with antiplatelet therapy in acute ischemic stroke (AIS) patients with concomitant non-valvular atrial fibrillation (NVAF) and extracranial/intracranial artery stenosis. Participants will be 1:1 randomized into anticoagulation alone or anticoagulation combined with antiplatelet therapy. The primary endpoint is composite events 3 months after enrollment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Anticoagulant Oral | Anticoagulation alone |
| DRUG | Anticoagulation combined with antiplatelet therapy | Anticoagulation combined with antiplatelet therapy |
Timeline
- Start date
- 2023-09-29
- Primary completion
- 2025-10-01
- Completion
- 2026-01-01
- First posted
- 2023-09-28
- Last updated
- 2024-03-18
Locations
2 sites across 1 country: China
Source: ClinicalTrials.gov record NCT06058130. Inclusion in this directory is not an endorsement.