| Not Yet Recruiting | Comparison of the Clinical Effects of Open, Closed, and Semi-close Hemorrhoidectomy. NCT07196865 | The Affiliated Hospital of Putian University | N/A |
| Recruiting | Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain NCT07399860 | Lomonosov Moscow State University Medical Research and Educational Center | Phase 2 |
| Withdrawn | The Sequestration of Holistic Stress Management Techniques for Adults NCT06098755 | Goddess Zena I. Jones | N/A |
| Recruiting | PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study) NCT07350460 | Andrea Saporito | N/A |
| Recruiting | HEMOVAR Study on Hemorrhoids and Varicose Veins NCT07317492 | Aydin Adnan Menderes University | — |
| Not Yet Recruiting | Comparison of Clinical Effects Between Routine and High-frequency Follow-up After Hemorrhoids Surgery NCT07183332 | The Affiliated Hospital of Putian University | N/A |
| Not Yet Recruiting | Effect of Red and Blue Light Irradiation on Wound Healing After Hemorrhoid Surgery NCT07121686 | The Affiliated Hospital of Putian University | N/A |
| Not Yet Recruiting | Evaluation of the Analgesic Efficacy of an Ultrasound-guided Transperineal Pudendal Block in Outpatient Hemorr NCT07015775 | GCS Ramsay Santé pour l'Enseignement et la Recherche | N/A |
| Recruiting | Trans-radial Superior Rectal Artery Embolisation for Haemorrhoids NCT06175325 | University Hospitals of North Midlands NHS Trust | N/A |
| Recruiting | Ultrasound-guided Sacral Erector Spinae Plane Block as a Sole Anesthetic Technique Versus Saddle Block in Hemo NCT06969274 | Ain Shams University | N/A |
| Completed | Evaluation of the Effectiveness of a Topical Medical Device in Wound Healing and Symptom Relief in the Postope NCT06872151 | University of Cagliari | Phase 4 |
| Completed | Hemorrhoidectomy With or Without Lateral Internal Sphincterotomy in Management of Patients With Hemorrhoids NCT06884774 | Minia University | N/A |
| Not Yet Recruiting | Comparison of the Clinical Efficacy and Safety of Endoscopic Superior Rectal Mucosal Ligation and Hemorrhoids NCT06649786 | The Affiliated Hospital of Qingdao University | N/A |
| Not Yet Recruiting | Hemorrhoidectomy Only Versus Hemorrhoidectomy With Lateral Internal Sphincterotomy NCT06588374 | Assiut University | N/A |
| Unknown | Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery? NCT06049524 | Center of Endourology "Endocenter" | — |
| Unknown | Mesoglycan for Acute Hemorrhoidal Disease NCT06101992 | Societa Italiana di Chirurgia ColoRettale | N/A |
| Unknown | Hemorrhoids: Options of Traditional Hemorrhoidectomy NCT06132152 | Center of Endourology "Endocenter" | N/A |
| Unknown | Ultrasound-guided Pudendal Nerve Block for Pain After Hemorrhoidectomy NCT05889962 | Taipei Medical University Hospital | N/A |
| Completed | Laser Versus Surgery in Anal Diseases in Inflammatory Bowel Patients NCT06216223 | Zagazig University | N/A |
| Completed | Effect of Sacral Erector Spinae Plane Block on Hemorrhoid and Pilonidal Sinus Surgery NCT06459739 | Erzincan Binali Yildirim Universitesi | N/A |
| Unknown | Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia NCT05990569 | Nepal Mediciti Hospital | N/A |
| Recruiting | SCI-Pex Study - Safety and Performance of PexyEazy®, a Device for Treatment of Hemorrhoids NCT05782010 | Developeration AB | N/A |
| Recruiting | Evaluation of Superior Rectal Arterial Embolization in Hemorrhoidal Disease NCT05697562 | Universitair Ziekenhuis Brussel | N/A |
| Completed | Efficacy of Stapled Hemorrhoidopexy for the Treatment of Obstructive Defecation Syndrome NCT06294470 | Universidad Central de Venezuela | N/A |
| Unknown | Cryotherapy Post-haemorrhoidectomy (CYPHER) Randomized Controlled Trial NCT06005727 | Singapore General Hospital | N/A |
| Unknown | Laser Hemorrhoidoplasty Versus Open Surgical Hemorrhoidectomy in Second and Third Degree Piles NCT05770141 | Assiut University | N/A |
| Unknown | Polidocanol Foam in Hemorrhoidal Disease in Patients With Liver Cirrhosis NCT05807425 | Universidade do Porto | Phase 2 / Phase 3 |
| Completed | Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofre NCT05519189 | Centre Hospitalier Departemental Vendee | Phase 4 |
| Recruiting | Efficacy and Safety of RAdiofrequency Versus HAL- RAR DOppler in Hemorrhoidal Pathology NCT04896268 | Elsan | N/A |
| Completed | Comparison Study of the Effect of Enema in Anal Surgery NCT05602987 | Taipei Medical University Shuang Ho Hospital | N/A |
| Completed | Hemostatic and Analgesic Effect of Gel Foam and Gauze With Bosmin After Anal Surgery NCT05605080 | Taipei Medical University Shuang Ho Hospital | N/A |
| Unknown | A Prospective Evaluation of Hemorrhoidal Surgery Outcome in Istanbul NCT05429060 | Istanbul Medipol University Hospital | — |
| Unknown | A Study on the Endoscopic Treatments of Hemorrhoids NCT05268575 | Fangyu Wang | N/A |
| Completed | Safety and Efficacy of CITI-002 in Adult Patients With Moderate Grade Hemorrhoids NCT05348200 | Citius Pharmaceuticals, Inc. | Phase 2 |
| Completed | Comparative Analysis of Hypobaric Versus Hyperbaric Bupivacaine for Spinal Anesthesia in Day-Case Anorectal Su NCT05409820 | Ankara City Hospital Bilkent | — |
| Completed | Preoperative Micronized Flavonoid Fraction (MFF) Use in Multimodal Anesthesia in Anorectal Surgery NCT05772351 | Center of Endourology "Endocenter" | N/A |
| Completed | Clinical Trial of Anusol Ointment for Symptom Relief in Patients With Haemorrhoids NCT05157711 | Church & Dwight Company, Inc. | Phase 3 |
| Unknown | The Two Treatment Methods Compared the Sclerosing Agent Injection and the Rubber Wrapping NCT05089500 | Renmin Hospital of Wuhan University | N/A |
| Completed | War-Drill Model Guided Treatment of Hemorrhoids With Nimsai Herbal (NAJ) NCT07034820 | Nimsai Academia | N/A |
| Completed | LaseRF Trial: Radiofrequency Ablation vs. Laser Hemorrhoidoplasty for Hemorrhoidal Disease NCT04981600 | Umraniye Education and Research Hospital | N/A |
| Completed | Milligan-Morgan Versus Dearterialization With Mucopexy NCT04863963 | Università degli Studi dell'Aquila | — |
| Unknown | Mucopexy Versus Laser Hemorrhoidoplasty for the Treatment of Hemorrhoidal Disease NCT04881344 | Ris Frederic | N/A |
| Completed | aCute HemORrhoidal Disease evALuation International Study NCT04578730 | Servier Affaires Médicales | — |
| Unknown | Treatment of Hemorrhoid With 1940nm Laser Procedure NCT05228054 | State Scientific Centre of Coloproctology, Russian Federation | N/A |
| Completed | Long-term Efficacy of Doppler Ligation With Mucopexy in the Treatment of Internal Hemorrhoidal Disease NCT04708678 | Fondation Hôpital Saint-Joseph | — |
| Completed | Efficacy of Ice Packing Application in Post-Hemorrhoidectomy Recovery NCT07186348 | Chang Gung Memorial Hospital | N/A |
| Completed | Study "HEMORROIDAL SURGERY AND Chronic Inflammatory Bowel Disease" NCT04692194 | Fondation Hôpital Saint-Joseph | — |
| Recruiting | Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease NCT03972956 | Renmin Hospital of Wuhan University | — |
| Completed | Implementation of a Minor Ailment Service in Community Pharmacy Practice NCT05247333 | Universidad de Granada | N/A |
| Completed | Impact of Moderate to Severe Pain in the Post-intervention Monitoring Room After Hemorrhoidectomy on the Lengt NCT04567485 | Fondation Hôpital Saint-Joseph | — |
| Recruiting | RCT Comparing Conventional Haemorrhoidectomy With Laser Haemorrhoidoplasty NCT04329364 | Sengkang General Hospital | Phase 2 / Phase 3 |
| Completed | Topical Analgesia Post-Haemorrhoidectomy NCT04276298 | University of Auckland, New Zealand | Phase 2 / Phase 3 |
| Completed | Longitudinal Description of Hemorrhoidal Pathology NCT04945408 | Fondation Hôpital Saint-Joseph | — |
| Recruiting | Ketamine for Post-operative Analgesia in Hemorrhoidectomy NCT04248205 | University of Oklahoma | Phase 4 |
| Unknown | Napoleon Trial: Optimal Treatment for Recurrent Haemorrhoidal Disease NCT04101773 | Maastricht University Medical Center | N/A |
| Completed | Topical vs Oral Metronidazole After Benign Anorectal Surgery NCT05038605 | Mansoura University | N/A |
| Completed | Effect of Early Warm Water Sitz Bath on Urinary Retention After Hemorrhoidectomy NCT04535765 | Cathay General Hospital | N/A |
| Unknown | Comparison of Rubber Band Ligation and Haemorrhoidectomy in Patients With Symptomatic Haemorrhoids Grade III NCT04621695 | Proctos Kliniek | N/A |
| Completed | The Use of Topical Anaesthetic in the Banding of Internal Haemorrhoids NCT04031131 | Julie Dawson | Phase 2 |
| Completed | Polidocanol Foam VS Artery Ligation in Hemorrhoidal Disease NCT04675177 | Universidade do Porto | Phase 2 / Phase 3 |
| Unknown | Multicentrique Prospective Evaluation of Radiofrequency Surgical Treatment of Homorrhoidal Disease NCT04229784 | Ramsay Générale de Santé | N/A |
| Completed | Topical Versus Oral Metronidazole Following Excisional Haemorrhoidectomy NCT03343509 | University of Auckland, New Zealand | Phase 4 |
| Completed | Data on the Impact of Different Treatment on the Quality of Life of Patients With Acute and Chronic Hemorrhoid NCT03743311 | Servier Russia | — |
| Unknown | Hemorrhoid Artery LigatioN Without Doppler Trial NCT04119401 | Russian Society of Colorectal Surgeons | N/A |
| Unknown | Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases NCT03780998 | SB Istanbul Education and Research Hospital | — |
| Unknown | Transarterial Coil Embolization of the Superior Rectal Arteries for Treatment of Stage II Hemorrhoids NCT03805087 | Humanitas Clinical and Research Center | N/A |
| Unknown | SRAE With Embospheres for Hemorrhoids. NCT03740321 | Eskisehir Osmangazi University | N/A |
| Completed | Efficacy of Lidocaine Gel Enema After Endoscopic Hemorrhoid Band Ligation for Relief of Post Procedural Pain NCT03797703 | Wake Forest University Health Sciences | Phase 1 |
| Unknown | Sclerotherapy With Polidocanol Foam In The Treatment Of Hemorrhoidal Disease In Patients With Bleeding Disorde NCT04188171 | Universidade do Porto | Phase 2 / Phase 3 |
| Unknown | Irritation and Anal Bleeding in Patients Affected by Hemorrhoids. NCT03569930 | University of Roma La Sapienza | Phase 4 |
| Completed | Effectiveness & Safety of Neofitoroid® in Hemorrhoidal Disease NCT03545724 | Aboca Spa Societa' Agricola | N/A |
| Completed | Perianal Nerval Block in Proctological Interventions NCT03405922 | University Hospital, Basel, Switzerland | Phase 4 |
| Completed | Pudendal Nerve Block for Hemorrhoidectomy NCT04251884 | Francesco Mongelli | N/A |
| Unknown | The Relationship Between Hemorrhoids and Smartphone Use in the Lavatory NCT03444389 | Yuzuncu Yil University | — |
| Completed | Ligation and Hemorrhoidopexy Technique Versus Ligation of Hemorrhoidal Arteries Using Ultrasound for Hemorrhoi NCT03298997 | Larissa University Hospital | N/A |
| Withdrawn | Multi-Drug Analgesia vs. Standard Solution for Anal Surgery NCT03105674 | Columbia University | Phase 4 |
| Unknown | Ligasure Hemorrhoidectomy Versus Open Hemorrhoidectomy NCT04139876 | Holbaek Sygehus | N/A |
| Suspended | Effect of Topical Trimebutine on Pain After Hemorrhoidectomy NCT03036111 | Mansoura University | N/A |
| Completed | Minimal Invasive Laser Hemorrhoidoplasty vs Conventional Excisional Hemorrhoidectomy in II-III Grade Hemorrhoi NCT04944407 | University of Campania Luigi Vanvitelli | N/A |
| Completed | Validation of Sodergren Score for Haemorrhoids in Malaysia NCT02884076 | University of Malaya | — |
| Unknown | Adding Ketamine to Low Dose Bupivacaine in Saddle Block for Perianal Surgery NCT03264430 | Esam Eldin Mohamed Abdalla | EARLY_Phase 1 |
| Completed | Evaluation of the Technique LHP (Laser HemorrhoidoPlasty) in Haemorrhoidal Prolapse Mini Invasive Surgery NCT03322527 | Fondation Hôpital Saint-Joseph | — |
| Completed | Calcium Dobesilate vs Flavonoids for the Treatment of Early Hemorrhoidal Disease NCT02782455 | Services Hospital, Lahore | Phase 4 |
| Withdrawn | Pain and Bleeding Following Hypertonic Saline Sclerotherapy Compared to Brand Ligation for Symptomatic Hemorrh NCT02851940 | American University of Beirut Medical Center | N/A |
| Unknown | Multicenter Prospective Trial on Hemorrhoids NCT03245086 | Stony Brook University | — |
| Completed | Prospective Randomized Trial About THD Versus Ligasure Hemorrhoidectomy for Grade III and IV Hemorrhoids NCT02654249 | Hospital Universitari de Bellvitge | N/A |
| Unknown | Trial on Use of Coloshield in Transanal and Anal Surgery NCT02579330 | Daniel Steinemann, MD | N/A |
| Completed | Ultrasound Guided Caudal Block for Benign Anal Surgery NCT03345511 | Universidad de Antioquia | N/A |
| Completed | HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment NCT02773420 | University of Illinois at Chicago | N/A |
| Completed | Safety and Efficacy of Hydrocortisone and Lidocaine Treatment of Grade I and II Hemorrhoids NCT02689856 | Citius Pharmaceuticals, Inc. | Phase 2 |
| Completed | Bleeding in Laser Haemorrhoidoplasty NCT04667169 | University of Malaya | N/A |
| Unknown | TSTstarr + for Treatment of Severe Prolapsed Hemorrhoids --- a Multi-center Randomized Controlled Clinical Tra NCT02295592 | Sixth Affiliated Hospital, Sun Yat-sen University | N/A |
| Completed | HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial NCT02216305 | Hospital Plató | N/A |
| Unknown | Evaluation of Allium Ampeloprasum Spp.Iranicum Cream Effect for the Management of Hemorrhoids Symptoms NCT02301052 | Shiraz University of Medical Sciences | Phase 1 / Phase 2 |
| Completed | Pre-Emptive Analgesia in Ano-Rectal Surgery NCT02402543 | University of Vermont | N/A |
| Completed | Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoi NCT02130830 | Pontificia Universidad Catolica de Chile | Phase 3 |
| Unknown | THD Versus Open Haemorrhoidectomy NCT02061176 | Holbaek Sygehus | N/A |
| Unknown | Topical 2% Lidocaine for the Treatment of Symptomatic Hemorrhoids NCT01961739 | University Hospital Dubrava | Phase 2 / Phase 3 |
| Completed | Hemorrhoids and Metalloproteinases, Observational Study NCT02358174 | University of Catanzaro | N/A |
| Completed | Effectiveness of Metronidazole in Pain Control Posthemorrhoidectomy NCT02328144 | Instituto Mexicano del Seguro Social | Phase 3 |
| Completed | Perineal Self-Acupressure NCT01867944 | University of California, Los Angeles | N/A |
| Terminated | Comparison Study of Hemorrhoid Surgery Using the Enseal Device to Standard Hemorrhoid Surgical Techniques NCT01422473 | Swedish Medical Center | N/A |
| Unknown | Hemorrhoidal Artery Ligation and Rectoanal Repair Versus Stapled Hemorrhoidopexy NCT01647763 | Cantonal Hospital of St. Gallen | N/A |
| Unknown | Efficacy and Tolerability of the Use of Varicell Compared With Daflon NCT01321619 | Vidfarma Indústria de Medicamentos Ltda. | Phase 3 |
| Unknown | Patients With Hemorrhoids Referred to a Surgical Specialist Department NCT01706601 | Karolinska Institutet | — |
| Completed | Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery NCT02961855 | Hospital de Viladecans | Phase 4 |
| Completed | Comparison Study of Surgical Staplers for the Treatment of Hemorrhoids NCT01306877 | Medtronic - MITG | N/A |
| Withdrawn | Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy NCT01099605 | United States Naval Medical Center, Portsmouth | N/A |
| Completed | To Evaluate the Dose Response of 3 Doses of Euphorbia Prostrata in Patients With First and Second Degree Hemor NCT01041911 | Panacea Biotec Ltd | Phase 2 |
| Completed | Trans-anal Hemorrhoidal Dearterialization (THD) vs. Hemorrhoidectomy NCT01244672 | Stony Brook University | N/A |
| Unknown | Diet and Lifestyle Intervention Study in Postpartum Women in China NCT01039051 | Huazhong University of Science and Technology | Phase 2 / Phase 3 |
| Unknown | EnSeal Device Versus Ferguson Technique in Hemorrhoidectomy NCT00853853 | Steven Schechter, M.D. | N/A |
| Completed | Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy NCT00744848 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Completed | Study of a New Circular Anal Dilator NCT00693459 | University Hospitals Cleveland Medical Center | N/A |
| Unknown | Clinical Efficacy and Safety Evaluation of the Drug Imescard Compound Water Smartweed Pills NCT00861562 | Hospital de Clinicas de Porto Alegre | Phase 3 |
| Unknown | Prospective Randomized Trial Comparing THD Versus Stapler Operation for 3rd Degree Hemorrhoids NCT00823784 | Societa Italiana di Chirurgia ColoRettale | Phase 3 |
| Completed | Prevention and/or Reduction of Hemorrhoids and/or Thrombosed External Hemorrhoids Using the HEM-AVERT Perianal NCT00487045 | Stetrix, Inc. | Phase 1 |
| Withdrawn | Local Versus General Anaesthesia in Stapled Hemorrhoidectomy NCT00512044 | University of Lausanne Hospitals | Phase 4 |
| Completed | A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointme NCT01881282 | Xian-Janssen Pharmaceutical Ltd. | Phase 4 |
| Completed | The Safety of Proctofoam-HC in the Third Trimester of Pregnancy NCT00405288 | The Hospital for Sick Children | — |
| Completed | Effect of Perioperative i.v. Low-dose S(+) Ketamine NCT00354029 | Asker & Baerum Hospital | Phase 4 |
| Unknown | Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine NCT00328900 | Rikshospitalet University Hospital | N/A |
| Completed | Local Anaesthetic Day-care Haemorrhoidectomy Challenges Traditional Concepts - a Randomised Controlled Trial NCT00503269 | East Kent Hospitals University NHS Foundation Trust | N/A |
| Completed | Ligasure Versus Diathermy Haemorrhoidectomy Under Local Anesthesia NCT00617448 | Hospital de Viladecans | N/A |
| Completed | Longo's Intervention in the Treatment of Hemorrhoids and Rectal Mucosal Prolapse NCT03383926 | Hospital de Mataró | N/A |
| Terminated | Trial to Evaluate Effect of Lactulose on Hard Stools in Patients With Hemorrhoids or Anal Fissures NCT00160290 | Solvay Pharmaceuticals | Phase 4 |
| Completed | Efficacy Study of Iferanserin to Treat Hemorrhoids NCT01483833 | Ventrus Biosciences, Inc | Phase 2 |
| Completed | Stapled Anopexy Versus Closed Haemorrhoidectomy for Haemorrhoids NCT00397137 | University of Dundee | N/A |
| Completed | Symptom Control 1-year After Circular Stapler Anopexy or Diathermy Excision for Prolapsed Haemorhoids NCT00841620 | Odense University Hospital | Phase 4 |
| Completed | Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagula NCT00630669 | University of California, Los Angeles | N/A |