NCT05038605

Topical vs Oral Metronidazole After Benign Anorectal Surgery

Topical Versus Oral Metronidazole for Pain Relief After Surgery for Benign Anorectal Conditions; a Prospective Randomized Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results. No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.

Conditions

• Hemorrhoids
• Anal Fissure
• Anal Fistula

Interventions

Type	Name	Description
DRUG	Topical metronidazole	Topical application of metronidazole cream on the anal verge every 8 hours after surgery
DRUG	oral metronidazole	Patients received oral metronidazole 500 mg tablets every 8 hours after surgery

Timeline

• Start date: 2020-01-24
• Primary completion: 2021-01-30
• Completion: 2021-03-01
• First posted: 2021-09-09
• Last updated: 2021-09-09

Locations

1 site across 1 country: Egypt