Trials / Conditions / Heart Failure, Systolic

Heart Failure, Systolic

123 registered clinical trials studyying Heart Failure, Systolic — 21 currently recruiting.

Status	Trial	Sponsor	Phase
Enrolling By Invitation	Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) NCT07252310	Weill Medical College of Cornell University	Phase 4
Recruiting	Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patien NCT07199088	University of Health Sciences Lahore	N/A
Not Yet Recruiting	Digoxin and Senolysis in Heart Failure and Diabetes Mellitus NCT06240403	University of Leeds	Phase 2
Enrolling By Invitation	The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure NCT07050706	The University of Hong Kong-Shenzhen Hospital	—
Terminated	Digital Remote Home Monitoring for Heart Failure NCT05988749	University of Texas Southwestern Medical Center	N/A
Recruiting	Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery. NCT06336746	Karlstad Central Hospital	—
Recruiting	Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany NCT06675552	AstraZeneca	—
Not Yet Recruiting	PhotobiomoduLation for pAtientS With Advanced hEart failuRe NCT06501313	Semmelweis University Heart and Vascular Center	N/A
Recruiting	Paced Heart Rate Acceleration for Cardiac Conditioning NCT06332391	Denice Hodgson-Zingman, MD	N/A
Not Yet Recruiting	IV Iron and SGLT2 Inhibitor on Ventricular Function and Myocardial Iron Content in Heart Failure With Iron Def NCT06434025	Hospital de Clinicas de Porto Alegre	Phase 3
Recruiting	Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery NCT05632432	Hospital District of Helsinki and Uusimaa	N/A
Unknown	Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure NCT05702970	University of Padova	Phase 4
Completed	Physiological Effects of Lactate in Individuals With Chronic Heart Failure NCT06121323	Henrik Wiggers	N/A
Recruiting	MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation NCT05933083	University of California, San Francisco	N/A
Recruiting	Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status NCT06009276	University of Virginia	—
Active Not Recruiting	Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cells NCT05925608	BioCardia, Inc.	Phase 1 / Phase 2
Recruiting	Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure NCT05677100	Procyrion	N/A
Active Not Recruiting	HIDRAdenitis Suppurativa and HEART Disease NCT05989945	Herlev and Gentofte Hospital	—
Recruiting	The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C) NCT05427370	Sunnybrook Health Sciences Centre	N/A
Completed	Financial Support in an Underserved and Low-Income Population With Heart Failure NCT05928026	University of Texas Southwestern Medical Center	N/A
Withdrawn	Effects of CRT Optimization as Assessed by Cardiac MR NCT04763460	Minneapolis Heart Institute Foundation	N/A
Recruiting	Pilot Study Lp299v Supplementation in Chronic Heart Failure NCT05752760	Medical College of Wisconsin	N/A
Completed	Precision of AI-Based Cardiac Ultrasound for LVEF in the Elderly NCT06478901	Hôpital Broca APHP	—
Recruiting	ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacin NCT06324682	University Hospital of Ferrara	—
Active Not Recruiting	Cardiac Structure and Function in Patients with Cystic Fibrosis NCT06084468	Herlev and Gentofte Hospital	—
Unknown	Machine Learning Enabled Time Series Analysis in Medicine NCT05802563	HagaZiekenhuis	—
Completed	Safety and Efficacy Study of AI LVEF NCT05140642	Cedars-Sinai Medical Center	N/A
Terminated	Levosimendan In Ambulatory Heart Failure Patients NCT04705337	Medical University of Bialystok	Phase 4
Recruiting	Robotic-assisted Exercise Training in Heart Failure With Reduced Ejection Fraction NCT05278429	German Heart Institute	N/A
Withdrawn	TRANSFORM Heart Failure with Reduced Ejection Fraction NCT04872959	Massachusetts General Hospital	N/A
Recruiting	Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction NCT04703842	Sardocor Corp.	Phase 1 / Phase 2
Completed	Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Me NCT05475028	University of Campania Luigi Vanvitelli	—
Recruiting	Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis NCT04950218	Herlev and Gentofte Hospital	—
Terminated	Acute Hemodynamic Effects of Pacing the His Bundle in Heart Failure NCT04701112	Region Skane	N/A
Completed	Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fra NCT04992832	Shanghai East Hospital	Phase 1 / Phase 2
Terminated	Cardiac Output in Heart Failure Patients With Mechanical Pumps NCT05195931	University of Colorado, Denver	—
Completed	Robotic-assisted Exercise Training in Heart Failure NCT04839133	German Heart Institute	N/A
Unknown	Sacubitril/Valsartan Versus Valsartan in Heart Failure With Improved Ejection Fraction NCT04803175	Samsung Medical Center	—
Unknown	Observational and Prospective Registry on Cardiac Contractility Modulation (CCM) Therapy NCT04902079	Monaldi Hospital	—
Completed	Effects of Ketones and Niacin in Heart Failure Patients NCT04703361	University of Aarhus	Phase 2
Completed	The Aortix CRS Pilot Study NCT04145635	Procyrion	N/A
Unknown	Prospective Monitoring of Angiotensin Receptor Neprilysin Inhibitor in Older Adults With Heart Failure and Fra NCT04743063	Brigham and Women's Hospital	—
Recruiting	Evaluating Infrasonic Hemodynography NCT04636892	Scripps Health	N/A
Active Not Recruiting	The Relationship Between Inflammatory ARTritis and CArdiac DIseAse NCT05647577	University Hospital, Gentofte, Copenhagen	—
Completed	Safety and Tolerability of Sacubitril/Valsartan in Heart Failure Patient With Reduced Ejection Fraction NCT05387967	National Institute of Cardiovascular Diseases, Pakistan	Phase 4
Unknown	His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction NCT04529577	Region Skane	N/A
Unknown	Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure NCT05008692	University Health Network, Toronto	—
Unknown	Dapagliflozin And Pulmonary Artery Hemodynamics in Heart Failure With Reduced Ejection Fraction Patients With NCT04570865	Scripps Health	Phase 4
Completed	The Fluoroless-CSP Trial Using Electroanatomic Mapping NCT03903107	Rush University Medical Center	N/A
Active Not Recruiting	Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure NCT04528004	University of Washington	EARLY_Phase 1
Unknown	Electrostimulation of Skeletal Muscles in Patients Listed for a Heart Transplant NCT04522609	Research Institute for Complex Problems of Cardiovascular Diseases, Russia	N/A
Completed	Physiological Signals, Activity and Posture for Surface Mounted Insertable Cardiac Monitor in Heart Failure St NCT04112576	Boston Scientific Corporation	—
Terminated	Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation NCT04342832	Maastricht University	N/A
Completed	Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program NCT04281849	VA Eastern Colorado Health Care System	N/A
Recruiting	Optimising Pacing for Contractility 2 NCT04201015	University of Leeds	Phase 2 / Phase 3
Unknown	Hypoxic Conditioning in Heart Failure NCT03537079	University Hospital, Grenoble	N/A
Unknown	Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19 NCT04325867	Professor Adrian Covic	N/A
Terminated	STandardized Ultra-conservative Or Physician-directed ICD Programming for Continuous Flow LVAD Support NCT04264182	The Cleveland Clinic	N/A
Active Not Recruiting	AB-1002 in Patients With Class III Heart Failure NCT04179643	AskBio Inc	Phase 1
Unknown	Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients NCT04083690	Allina Health System	N/A
Unknown	Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure NCT03871699	Hospital Moinhos de Vento	Phase 4
Completed	Virtual Visits to Optimize Research Trial Offerings to HF Patients NCT04064541	The Cleveland Clinic	N/A
Withdrawn	Quartet Lead With Defibrillator Multisite Algorithmic Cardiac Resynchronisation Therapy Optimisation NCT02997670	Cardiff and Vale University Health Board	N/A
Suspended	How is COGNItive Function Affected by Cardiac Resynchronisation Therapy? NCT03755570	Royal Cornwall Hospitals Trust	—
Unknown	SyncAV Study: Investigation of the Efficacy of the SyncAV Fusion Pacing Algorithm on Exercise NCT03768804	University of Oxford	N/A
Completed	COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure NCT03917459	Novartis Pharmaceuticals	Phase 3
Unknown	Fluid Restriction in Patients With Heart Failure NCT04611594	Hospital de Clinicas de Porto Alegre	N/A
Completed	Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2 NCT03797001	Virginia Commonwealth University	Phase 2
Unknown	Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Fail NCT03830957	Rajaie Cardiovascular Medical and Research Center	N/A
Unknown	Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin NCT03553303	Oslo University Hospital	Phase 4
Completed	Randomized, Double-Blind, Placebo-Controlled, Safety and Tolerability Study of ITI-214 in Patients With Heart NCT03387215	Intra-Cellular Therapies, Inc.	Phase 1 / Phase 2
Unknown	Atrial FIbrillation Treatment With Cryoballoon in Heart failurE (AFICHE) NCT03573869	G.Gennimatas General Hospital	N/A
Terminated	Effect of Dietary Nitrate Ingestion in Heart Failure NCT03511248	Queen Mary University of London	Phase 2
Completed	A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DE NCT03374891	University of Colorado, Denver	N/A
Terminated	ANTHEM-HFrEF Pivotal Study NCT03425422	LivaNova	N/A
Unknown	VItamin D as a Novel Determinant of Injurious Cardiac Remodelling After acuTE Myocardial Infarction NCT03086746	University of Leeds	—
Terminated	Efficacy of Cardio-Oncology Rehabilitation Exercise for Women With Breast Cancer and Treatment Related Cardiot NCT03089502	University Health Network, Toronto	N/A
Completed	Hemodynamic-GUIDEd Management of Heart Failure NCT03387813	Abbott Medical Devices	N/A
Withdrawn	Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy. NCT03392740	Ascension Health	Phase 4
Completed	Low-salt Bread in Heart Failure, Pilot Study NCT05589428	VieCuri Medical Centre	N/A
Completed	Patient Reported Outcomes inVestigation Following Initiation of Drug Therapy With Entresto (Sacubitril/Valsart NCT03387163	Novartis Pharmaceuticals	—
Unknown	Mechanistic Clinical Trial of Advanced Imaging for CRT NCT03398369	University of Virginia	N/A
Terminated	Optimizing CRT With ECGI NCT03492788	Washington University School of Medicine	N/A
Completed	Cardiac Uptake of Metformin, Visualized by Positron Emission Tomography NCT03122769	Henrik Wiggers	Phase 1
Completed	Effect of Sodium Intake on Brain Natriuretic Peptide Levels in Patients With Heart Failure NCT03351283	Instituto Mexicano del Seguro Social	N/A
Completed	Optimising Pacemaker Therapy Using Multi-point Pacing (the OPT-MPP Study) NCT03220659	University of Leeds	N/A
Completed	ECG Belt vs. Echocardiographic Optimization of CRT NCT03305692	Alan J. Bank, MD	N/A
Withdrawn	The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG NCT03227393	University of Cincinnati	N/A
Completed	Reprogramming to Prevent Progressive Pacemaker-induced Remodelling NCT03627585	University of Leeds	N/A
Completed	Implementation of Telerehabilitation In Support of HOme-based Physical Exercise for Heart Failure NCT03183323	Helse Nord-Trøndelag HF	N/A
Withdrawn	Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease NCT03062176	Virginia Commonwealth University	Phase 2
Completed	Ketones in Heart Failure - Effects on Cardiac Efficiency NCT03073356	University of Aarhus	Phase 2
Completed	Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency NCT03079518	RWTH Aachen University	Phase 2
Withdrawn	Mobile App With Patient Financial Incentives for Adherence to Heart Failure Medications & Daily Self-Weighing NCT03034551	Wellth Inc.	N/A
Completed	Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure NCT02810132	Aarhus University Hospital	Phase 2
Completed	CardiAMP™ Cell Therapy for Heart Failure Trial NCT02438306	BioCardia, Inc.	Phase 3
Completed	Pulse Reduction On Beta-blocker and Ivabradine Therapy NCT02973594	University of Colorado, Denver	Phase 4
Unknown	Cardiac Magnetic Resonance Imaging After Cardiac Resynchronization Therapy NCT03183011	Kenneth Bilchick, MD	N/A
Unknown	Telesonography for Visually Estimating Ejection Fraction NCT02960685	Hanyang University	—
Completed	Treatment of Diabetes in Patients With Systolic Heart Failure NCT02920918	Virginia Commonwealth University	Phase 4
Completed	SGLT2 Inhibition in Diabetes and Heart Failure NCT02862067	Virginia Commonwealth University	—
Completed	Nicotinamide Riboside in Systolic Heart Failure NCT03423342	University of Washington	Phase 1 / Phase 2
Unknown	Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure NCT02797340	Aarhus University Hospital	Phase 4
Completed	Short Term Oral Iron Supplementation in Systolic Heart Failure Patients Suffering From Iron Deficiency Anemia NCT02998697	National Cardiovascular Center Harapan Kita Hospital Indonesia	Phase 2 / Phase 3
Completed	A Novel Home-based Physical Activity Intervention for Stable Chronic Heart Failure Patients NCT03677271	Newcastle-upon-Tyne Hospitals NHS Trust	N/A
Unknown	Inspiratory Muscle Training for Breathless Patients With Chronic Obstructive Pulmonary Disease and Heart Failu NCT02579200	Queen's University	Phase 4
Completed	Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure NCT02401126	Queen's University	Phase 4
Completed	Impact of Cardiac Rehabilitation on Acute Heart Failure Patients With Cognitive Impairment NCT05726565	Chang Gung Memorial Hospital	—
Unknown	Acute Changes in Bioimpedance During Cardiac Resynchronization Therapy NCT03640000	Oslo University Hospital	N/A
Completed	Kyoto Congestive Heart Failure Study NCT02334891	Kyoto University, Graduate School of Medicine	—
Unknown	Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease NCT02099903	InCor Heart Institute	N/A
Completed	Evaluation of Cardiotoxic Effects of Bortezomib NCT02026505	Oregon Health and Science University	—
Completed	R-wave Optimisation in Cardiac Resynchronisation Therapy Study NCT02080000	The Royal Bournemouth Hospital	N/A
Terminated	MADIT ASIA Cardiac Resynchronization Trial NCT01872234	Boston Scientific Corporation	Phase 3
Completed	Blended Collaborative Care for Heart Failure and Co-Morbid Depression NCT02044211	University of Pittsburgh	Phase 2 / Phase 3
Completed	Predicting Heart Failure Outcomes With Biomarkers and Imaging NCT07332520	Xinjiang Medical University	—
Unknown	Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillati NCT01553045	University Hospital, Linkoeping	—
Completed	Patient and Physician Survey Determinants of Appropriate ICD Utilization NCT01514773	Todd M Koelling, MD	—
Completed	Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging NCT01129635	Emory University	N/A
Completed	Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients NCT02946476	Ospedale Maggiore Di Trieste	—
Completed	Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT) NCT01577446	Ospedale Santa Maria di Loreto Mare	N/A
Unknown	Prediction of Mortality After CIED Implantation (PM-CIED) NCT05396313	Shanghai Zhongshan Hospital	—
Completed	Growth Hormone in Ischemic Heart Failure NCT04420481	Göteborg University	Phase 3