Trials / Completed
CompletedNCT03122769
Cardiac Uptake of Metformin, Visualized by Positron Emission Tomography
Cardiac Uptake of Metformin and Expression of Metformin Membrane Transporter Proteins in the Human Failing Myocardium
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 6 (actual)
- Sponsor
- Henrik Wiggers · Academic / Other
- Sex
- All
- Age
- 18 Years – 99 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of the study is to evaluate if metformin is taken up into the failing myocardium. Recent experimental and epidemiological studies have shown beneficial effects of metformin on heart failure. It is unknown whether this effect is direct or indirect. The aim of the study is to investigate if metformin is taken up in heart failure using a novel 11C-metformin tracer and positron emission tomography (PET).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | 11C-metformin | 200 MBq of 11C-metformin is injected in the cubital vein. The participant is then scanned for 120 min using Positron Emission Tomography |
Timeline
- Start date
- 2017-12-01
- Primary completion
- 2018-04-10
- Completion
- 2018-04-10
- First posted
- 2017-04-21
- Last updated
- 2018-04-20
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT03122769. Inclusion in this directory is not an endorsement.