| Not Yet Recruiting | A New Way to Share Radiation Therapy Plans Between Doctors, CORRECT Trial NCT07282444 | Wake Forest University Health Sciences | N/A |
| Recruiting | The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and NCT07285044 | Mayo Clinic | Phase 2 |
| Recruiting | Tongue-out Radiation Therapy (TORT) for the Mitigation of Radiotherapy-related Toxicities in Patients With Hea NCT07227792 | Yvonne Mowery | N/A |
| Recruiting | A Financial Intervention (Financial Compass) to Identify and Address Financial Hardship Among Head and Neck Ca NCT06896695 | Roswell Park Cancer Institute | N/A |
| Recruiting | Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematolog NCT07118176 | Jonsson Comprehensive Cancer Center | Phase 1 |
| Recruiting | Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Ne NCT06985784 | City of Hope Medical Center | N/A |
| Recruiting | Accelerator-based BNCT (Boron Neutron Capture Therapy) for Head and Neck Carcinoma. NCT07058116 | Neutron Therapeutics, LLC | Phase 1 |
| Recruiting | Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer NCT06627270 | Case Comprehensive Cancer Center | Phase 2 |
| Recruiting | Heavy Strength Training in Head and Neck Cancer Survivors NCT06289049 | University of Alberta | Phase 2 |
| Recruiting | Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatmen NCT06572423 | Jonsson Comprehensive Cancer Center | N/A |
| Withdrawn | Defining Musical Toxicity and Its Effect on Patient Well-being NCT06494046 | Mayo Clinic | — |
| Recruiting | An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence NCT06420219 | University of Southern California | — |
| Completed | Optimization of Communication Between Surgery and Pathology NCT07378345 | Heidelberg University | N/A |
| Completed | An Exercise Prehabilitation Intervention for Improving Mobility and Recovery Outcomes in Patients Undergoing H NCT06079697 | OHSU Knight Cancer Institute | N/A |
| Withdrawn | StrataXRT for the Prevention and Treatment of Radiation Dermatitis in Breast Cancer or Head and Neck Cancer Pa NCT05073172 | OHSU Knight Cancer Institute | N/A |
| Recruiting | Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy NCT06183268 | Covenant Health Cancer Center | N/A |
| Recruiting | Repeatability and Reproducibility of the ADC Map in Head and Neck Cancer. Prospective Multicenter Study NCT06749301 | Regina Elena Cancer Institute | — |
| Recruiting | Therapeutic Vaccine in Patients With Human Papillomavirus HPV-positive Oropharyngeal Cancer NCT06007092 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 1 / Phase 2 |
| Completed | The SHINE-MDT Randomized Controlled Trial NCT05828004 | West China Hospital | N/A |
| Recruiting | Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head an NCT05526924 | University of Chicago | Phase 1 |
| Withdrawn | A Pneumatic Compression Device for the Treatment of Lymphedema in Patients With Stage II-IV Head and Neck Canc NCT05512767 | Mayo Clinic | N/A |
| Recruiting | A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer NCT05544136 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection NCT05334069 | Alliance for Clinical Trials in Oncology | — |
| Recruiting | AIOCC Italian Registry on Head and Neck Carcinomas NCT06248944 | Italian Head&Neck Society | — |
| Active Not Recruiting | Predicting Radiological Extranodal Extension in Oropharyngeal Carcinoma Patients Using AI NCT05565313 | Maastricht Radiation Oncology | — |
| Completed | Evaluating Patient Reported Outcomes in Radiation Therapy, the PRO-RT Study NCT05224271 | Mayo Clinic | — |
| Active Not Recruiting | Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT NCT05075980 | Mayo Clinic | Phase 2 |
| Completed | Remote Monitoring in Cancer Care: A Platform Study NCT05018208 | Mayo Clinic | — |
| Terminated | Milademetan in Advanced/Metastatic Solid Tumors NCT05012397 | Rain Oncology Inc | Phase 2 |
| Active Not Recruiting | Interdisciplinary Interventions to Address Pain Management Among Head and Neck Cancer Patients NCT05077072 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | A Digital Intervention Protocol to Enhance Recovery After Head and Neck Surgery NCT04814524 | OHSU Knight Cancer Institute | N/A |
| Recruiting | Customized 3D Printed Oral Stents During Head and Neck Radiotherapy NCT04870762 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Post-Operative Radiotherapy De-Escalation of Negative Nodal Regions in Head and Neck Squamous Cell Carcinoma NCT05650034 | National Cancer Institute, Egypt | N/A |
| Completed | Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer NCT04788264 | Thomas Jefferson University | N/A |
| Active Not Recruiting | Dyadic Yoga Intervention for the Improvement of Healthcare Utilization and Quality of Life in Patients With He NCT04890834 | M.D. Anderson Cancer Center | N/A |
| Terminated | Collection of Clinical Data and Specimens for Research on Head and Neck and Communication Disorders NCT04618432 | National Institute on Deafness and Other Communication Disorders (NIDCD) | — |
| Active Not Recruiting | Personal Health Train for Radiation Oncology in India and The Netherlands NCT04655469 | Maastricht Radiation Oncology | — |
| Completed | Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer NCT03993353 | University of California, San Diego | Phase 2 |
| Completed | IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma NCT03795610 | Assuntina G. Sacco, MD | Phase 2 |
| Completed | Effects of Human Papillomavirus Diagnosis on Relationships of Patients With Head and Neck Cancer NCT04666428 | Thomas Jefferson University | — |
| Recruiting | Cancer Genetic Testing in Ethnic Populations NCT04475640 | Mayo Clinic | N/A |
| Recruiting | Oropharynx (OPX) Biomarker Trial NCT06356272 | Mayo Clinic | — |
| Active Not Recruiting | Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal a NCT04147494 | Jonsson Comprehensive Cancer Center | EARLY_Phase 1 |
| Active Not Recruiting | High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation NCT04151082 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Terminated | Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer NCT04110249 | Roswell Park Cancer Institute | N/A |
| Completed | Pain Management for Head and Neck Cancer Survivors NCT05115825 | OHSU Knight Cancer Institute | N/A |
| Completed | Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or NCT03902535 | City of Hope Medical Center | — |
| Terminated | Study Evaluating The Role of ClO2 on Mucositis for Pt. Undergoing Head/Neck Radiotherapy NCT03602066 | University of Arizona | Phase 2 |
| Active Not Recruiting | Clinical Data Collection in Studying Clinical Factors Associated With Post-Surgery Chronic Opioid Use in Patie NCT03888651 | M.D. Anderson Cancer Center | — |
| Withdrawn | Near-Infrared Image Guided Surgical Resection With Indocyanine Green in Treating Patients With Head and Neck C NCT03745690 | Jonsson Comprehensive Cancer Center | Phase 1 / Phase 2 |
| Completed | FALCOn (Facteur AnthropoLogique Cancer Orl) NCT03663985 | Institut Claudius Regaud | — |
| Active Not Recruiting | Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors NCT03612531 | M.D. Anderson Cancer Center | N/A |
| Completed | Effects of Avmacol® in the Oral Mucosa of Patients Following Curative Treatment for Tobacco-related Head and N NCT03268993 | University of Pittsburgh | N/A |
| Completed | Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Ge NCT03602079 | Klus Pharma Inc. | Phase 1 / Phase 2 |
| Unknown | A Study of Anlotinib in Recurrent/Metastatic Head and Neck Adenocarcinomas NCT03591666 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Recruiting | VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or NCT03556228 | VM Oncology, LLC | Phase 1 / Phase 2 |
| Completed | Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous NCT03524326 | Memorial Sloan Kettering Cancer Center | Phase 1 |
| Completed | Remote Activity Monitored by Fitbit Charge 3 in Investigating Daily Step and Sleep Data in Participants With H NCT03489252 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | N/A |
| Completed | Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma NCT03370276 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 / Phase 2 |
| Withdrawn | Nestle Impact Advanced Recovery in Improving Surgery Recovery in Patients With Head and Neck Cancer NCT03261180 | OHSU Knight Cancer Institute | N/A |
| Completed | Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer NCT03154190 | Stanford University | N/A |
| Completed | Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Un NCT03135782 | OHSU Knight Cancer Institute | N/A |
| Completed | Low-Carbohydrate Normocaloric Diet in Patients With Head and Neck Carcinoma (HNC) NCT02555176 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | N/A |
| Completed | Nurse-Driven Telephone Intervention in Improving Side Effects in Cancer Patients Undergoing Chemotherapy NCT03964896 | M.D. Anderson Cancer Center | N/A |
| Completed | Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps NCT03340038 | University of California, Davis | N/A |
| Completed | Pembrolizumab Plus Docetaxel for the Treatment of Recurrent or Metastatic Head and Neck Cancer NCT02718820 | Medical University of Vienna | Phase 1 / Phase 2 |
| Completed | A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combi NCT02586987 | AstraZeneca | Phase 1 |
| Active Not Recruiting | Bioelectrical Impedance Analysis in Estimating Body Composition in Patients With Stage I-IV Head and Neck Canc NCT02615275 | M.D. Anderson Cancer Center | N/A |
| Active Not Recruiting | Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymph NCT02465060 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | Re-irradiation of Recurrent Head and Neck Cancer NCT01973179 | Technische Universität Dresden | — |
| Completed | Continuous Activity Monitoring During Fractionated Radiotherapy in Patients With Head and Neck, Lung, or Gastr NCT02649569 | Montefiore Medical Center | — |
| Completed | Modified Dakin's Solution in Reducing Radiation-Induced Dermatitis in Patients With Head and Neck Cancer Under NCT02369835 | Stanford University | Phase 3 |
| Completed | Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patie NCT02474095 | Roswell Park Cancer Institute | N/A |
| Completed | Phase I Study of Lurbinectedin (PM01183) in Combination With Paclitaxel, With or Without Bevacizumab, in Selec NCT01831089 | PharmaMar | Phase 1 |
| Active Not Recruiting | Neurofeedback in Decreasing Acute Radiotherapy-Induced Pain in Patients With Head and Neck Cancer NCT02543320 | M.D. Anderson Cancer Center | N/A |
| Terminated | IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell Carcinoma of the Head and Nec NCT01507467 | Danish Head and Neck Cancer Group | Phase 3 |
| Active Not Recruiting | Medical Data Collection of Patients With Head and Neck Cancer Treated With Proton Therapy NCT01627093 | M.D. Anderson Cancer Center | — |
| Completed | Feasibility of VMAT and CBCT for Head and Neck Carcinomas NCT01384890 | British Columbia Cancer Agency | Phase 1 |
| Completed | Trial of OTD70DERM® in Radio-dermatitis Induced by Radiotherapy-Erbitux® NCT01228565 | Groupe Oncologie Radiotherapie Tete et Cou | Phase 3 |
| Recruiting | Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy NCT00991094 | M.D. Anderson Cancer Center | — |