NCT04110249

Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer

A Pilot Study of Photoacoustic Imaging (PAI) in H&Amp;N Cancer Patients

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Roswell Park Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial studies how well photoacoustic imaging works in measuring tumors and normal tissue in patients with head and neck cancer. Photoacoustic imaging (PAI) is a low-risk imaging method that provides information about the oxygenation of tissues using a combination of light and ultrasound techniques. This study may help doctors determine if PAI is correlated with clinical responses of both tumor (for example: shrinking, swelling or disappearing) and normal tissues (for example: skin redness, dry mouth, appearance of sores, healing of skin or mucosa). If there is a correlation with clinical responses, then doctors may develop PAI as method for measuring response to earlier treatment.

Detailed description

PRIMARY OBJECTIVE: I. Define the feasibility of the current photoacoustic imaging (PAI) technology in head and neck (H\&N) cancer patients. SECONDARY OBJECTIVE: I. Define the utility of the current PAI in H\&N cancer patients. OUTLINE: PART I: Patients undergo PAI before the start of chemoradiation therapy, weekly during 7 weeks of chemoradiation, and again 3-4 months after completion of chemoradiation therapy. PART II (CANCER-FREE WITH XEROSTOMIA): Patients undergo PAI at baseline, up to twice during acupuncture-like transcutaneous nerve stimulation (ALTENS) therapy, once after ALTENS, and at 3-6 months follow up.

Conditions

• Head and Neck Carcinoma
• Head and Neck Lymph Node
• Head and Neck Squamous Cell Carcinoma
• Laryngeal Neoplasm
• Radiation Therapy Recipient

Interventions

Type	Name	Description
PROCEDURE	Photoacoustic Imaging	Undergo PAI
PROCEDURE	Transcutaneous Acupoint Electrical Stimulation	Undergo ALTENS

Timeline

• Start date: 2019-09-06
• Primary completion: 2022-12-29
• Completion: 2022-12-29
• First posted: 2019-10-01
• Last updated: 2023-04-10

Locations

1 site across 1 country: United States