| Recruiting | Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Foca NCT07505004 | Praxis Precision Medicines | Phase 3 |
| Recruiting | Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables NCT07012148 | Mayo Clinic | N/A |
| Not Yet Recruiting | Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epil NCT07318870 | Fondation Ophtalmologique Adolphe de Rothschild | Phase 2 |
| Recruiting | A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures NCT07219407 | Rapport Therapeutics Inc. | Phase 2 |
| Recruiting | Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy NCT07193277 | First Affiliated Hospital of Wenzhou Medical University | Phase 4 |
| Recruiting | Thalamic Recordings in Children Undergoing SEEG NCT06453759 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Recruiting | An Open-label Study to Evaluate Safety, Tolerability, and Efficacy of CB03-154 in Subjects Diagnosed With Epil NCT07238868 | Shanghai Zhimeng Biopharma, Inc. | Phase 2 |
| Active Not Recruiting | Wearable Epileptic Seizure Prediction and Alert Glasses Based on Neuromorphic Computing NCT07139457 | Oman Ministry of Health | N/A |
| Recruiting | Sleep Architecture & Cognition in Focal Epilepsy NCT05794295 | University of California, Davis | N/A |
| Recruiting | Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery. ( EpiGrid ) NCT06205160 | Neurosoft Bioelectronics SA | N/A |
| Withdrawn | Efficacy of Intersectional Short Pulse Stimulation for Terminating Seizures NCT04998123 | NYU Langone Health | N/A |
| Not Yet Recruiting | A Study to Evaluate the Safety, Tolerability, and Efficacy of CB03-154 in Adult Patients With Focal Epilepsy NCT06612775 | Shanghai Zhimeng Biopharma, Inc. | Phase 2 |
| Enrolling By Invitation | Long-term Safety and Tolerability of BHV-7000 NCT06443463 | Biohaven Therapeutics Ltd. | Phase 2 |
| Recruiting | Cognitive Impairment in Drug-resistant and Drug-responsive Focal Cryptogenic Epilepsy NCT06210022 | IRCCS San Raffaele | — |
| Recruiting | Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy NCT06309966 | Biohaven Therapeutics Ltd. | Phase 2 / Phase 3 |
| Not Yet Recruiting | Assessment of Patients With Drug-resistant Temporal Lobe Epilepsy With EEG Extended With Intra-auricular Elect NCT06366009 | Przemyslaw Kunert | — |
| Recruiting | A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy NCT06132893 | Biohaven Therapeutics Ltd. | Phase 2 / Phase 3 |
| Recruiting | Breathing Rescue for SUDEP Prevention NCT05981755 | The University of Texas Health Science Center, Houston | N/A |
| Enrolling By Invitation | An Open-label Study of XEN1101 in Epilepsy NCT05718817 | Xenon Pharmaceuticals Inc. | Phase 3 |
| Recruiting | Study of Transcranial Direct Current Stimulation to Treat Epilepsy NCT05673915 | Mayo Clinic | N/A |
| Unknown | Seizures Detection in Real Life Setting NCT05635396 | Reliev Technologies | N/A |
| Unknown | The Efficacy and Safety of Lamotrigine Versus Carbamazepine in Focal Epilepsy NCT05748236 | Dhaka Medical College | Phase 4 |
| Withdrawn | ENACT: A Study of ENX-101 as Adjunctive Treatment in Patients With Focal Seizures NCT05481905 | Engrail Therapeutics INC | Phase 2 |
| Unknown | TMS Combined With EEG/EMG as a Biomarker Predicting Antiepileptic Drug Response NCT05278221 | Aristotle University Of Thessaloniki | N/A |
| Active Not Recruiting | Transcranial Magnetic Stimulation (rTMS) for Refractory Focal Epilepsy NCT06681480 | Comenius University | N/A |
| Unknown | Clinical Evaluation of Interstitial Laser Thermal Therapy Under Continuous MRI Monitoring as a Minimally Invas NCT05198882 | Assistance Publique - Hôpitaux de Paris | Phase 1 |
| Recruiting | Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy NCT05100771 | University Hospital, Tours | — |
| Terminated | RNS System RESPONSE Study NCT04839601 | NeuroPace | N/A |
| Terminated | A Study of Lu AG06466 in Participants With Treatment Resistant Focal Epilepsy NCT05081518 | H. Lundbeck A/S | Phase 1 |
| Recruiting | Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery NCT04986683 | Wayne State University | N/A |
| Unknown | Priming the Epileptic Brain: tVNS to Improve Efficacy of add-on AED in Patients With Focal Epilepsy NCT05180916 | Eindhoven University of Technology | N/A |
| Unknown | Clinical Efficacy and Safety of Perampanel Monotherapy in the Treatment of Children With Focal Epilepsy NCT05497193 | Yang Xinwei | — |
| Recruiting | Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients NCT04653012 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Terminated | Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion NCT04529954 | Cerebral Therapeutics LLC | Phase 1 / Phase 2 |
| Unknown | Prospective Open-label Evaluation of Cenobamate Adjunctive Treatment of Adults With Refractory Focal Epilepsy NCT04879433 | Mid-Atlantic Epilepsy and Sleep Center, LLC | — |
| Unknown | Novel Network Analysis of Intracranial Stereoelectroencephalography NCT03916848 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Terminated | Long-term Cardiac Monitoring in Epilepsy NCT03955432 | Northwell Health | N/A |
| Active Not Recruiting | A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy NCT03796962 | Xenon Pharmaceuticals Inc. | Phase 2 |
| Completed | Efficacy and Safety of Rapid Titration Protocols of Lacosamide NCT03607851 | Seoul National University Hospital | Phase 4 |
| Recruiting | Atlas of Human Cognition by SEEG (MAPCOG-SEEG) NCT03644732 | University Hospital, Grenoble | — |
| Unknown | Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortic NCT03321240 | University Hospital, Strasbourg, France | — |
| Completed | Improvement of the Accuracy of Spatial Representation of Invasive Exploratory Electrodes in Focal Epilepsy NCT02898935 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Unknown | Post-market Study of AMPA Receptor Antagonists for Epilepsy Patients in Hong Kong NCT03457961 | Chinese University of Hong Kong | — |
| Completed | ZEDEBAC: Zebinix Effects in Dependency of Baseline Conditions NCT03082222 | Eisai GmbH | — |
| Unknown | Cortical Excitability Assessment Using Paired Pulses NCT02245061 | Hospices Civils de Lyon | N/A |
| Terminated | Lacosamide IV and EEG/EKG (LIVE) Study NCT01724918 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |
| Completed | Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy NCT01772654 | Mayo Clinic | N/A |
| Completed | The Human Epilepsy Project NCT02126774 | NYU Langone Health | — |
| Completed | The Effects on Cognitive Function of Levetiracetam (Keppra®) Compared to Carbamazepine (Tegretol®, Carmazepine NCT02208492 | Yonsei University | Phase 4 |
| Completed | National Study on the Interest of EEG-fMRI in the Presurgical Evaluation of Partial Epilepsies Drug NCT03278210 | University Hospital, Lille | — |
| Completed | Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy NCT01311440 | Oslo University Hospital | N/A |
| Completed | A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The D NCT00855738 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Phase 4 |
| Completed | Study on the Treatment of Elderly Patients With Older and Newer Antiepileptic Drugs NCT00438451 | Johannes Gutenberg University Mainz | Phase 4 |