NCT01311440

Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy

Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy - a Controlled, Randomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

In Oslo University Hospital, department of complex epilepsy, offer ketogenic diet to treat children with medically intractable epilepsy. From 2009 we added modified Atkins diet as a treatment option for children up to 18 years. We now initiate an open, prospective, randomized and controlled study with the aim to test the efficacy of treatment with modified Atkins diet in adults with focal and generalized epilepsy diagnoses, in order to evaluate whether this treatment should be offered to patients on a permanent basis.

Detailed description

Poorly controlled epilepsy in adults affects health and quality of life in many ways. Within this heterogenous population there are individuals who are motivated for a very strict diet in order to reduce seizures. Among adults with epilepsy 75 - 80 % are diagnosed with focal epilepsy, while 20 - 25 % have generalized onset of seizures. We plan to include 92 patients with focal epilepsy diagnosis. Those are randomized into diet and control groups. During the inclusion period we also treat patients with generalized epilepsy that qualify for participation, but these are not to be randomized, rather they will follow the diet group course. We assume 18 - 23 patients with generalized epilepsy will be included in the project.

Conditions

• Epilepsy
• Focal Epilepsy
• Generalized Epilepsy

Interventions

Type	Name	Description
OTHER	Modified Atkins diet treatment	Eat a diet containing 16 grams of carbohydrates per day, maximize on fat. Assure sufficient intake of micronutrients.

Timeline

• Start date: 2011-03-01
• Primary completion: 2017-06-01
• Completion: 2017-07-01
• First posted: 2011-03-09
• Last updated: 2017-09-19

Locations

1 site across 1 country: Norway