| Not Yet Recruiting | Transverse vs Longitudinal Mucosal Incision During POEM NCT07425977 | Universidad Nacional de Colombia | Phase 3 |
| Recruiting | Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy NCT06721520 | The Cleveland Clinic | Phase 2 / Phase 3 |
| Recruiting | MARIMPACH : Contribution of High-resolution Manometry With Impedancemetry for the Evaluation of Esophageal Cle NCT06230536 | University Hospital, Bordeaux | — |
| Not Yet Recruiting | Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia NCT06027190 | Zhang Nina | N/A |
| Unknown | Safety and Efficacy of a Novel Flexible Bipolar in POEM NCT06264466 | Instituto Ecuatoriano de Enfermedades Digestivas | N/A |
| Recruiting | Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy ( NCT06405412 | Umraniye Education and Research Hospital | — |
| Recruiting | Routine Versus Symptomatic Protein Pump Inhibitor Therapy for Prevention of Gastroesophageal Reflux After Per NCT05899842 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Unknown | Respiratory and Hemodynamic Implications of Endoscopic Myotomy of the Esophagus and Stomach NCT05602272 | Centre Hospitalier Universitaire Vaudois | — |
| Unknown | Quality of Life After POEM for Achalasia NCT05010889 | First Affiliated Hospital, Sun Yat-Sen University | — |
| Unknown | Study on the Relationship Between Pathological Features of Achalasia and Prognosis of Per-oral Endoscopic Myot NCT05113173 | Fandong Meng | — |
| Recruiting | Assessment of Different Modified POEM for Achalasia NCT04578769 | Peking Union Medical College Hospital | N/A |
| Completed | Assessment of the Neuro-glio-epithelial Unit (NGEU) in Biopsies Taken During Peroral Endoscopic Myotomy (POEM) NCT04112693 | Nantes University Hospital | N/A |
| Unknown | Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent) NCT03962179 | University Hospital of Cologne | N/A |
| Completed | Ropivacaine For Post-POEM Pain Control NCT03702647 | Lawrence Charles Hookey | N/A |
| Unknown | to Explore the Influence of Longitudinal Muscle on the Prognosis of Achalasia Patients After Peroral Endoscopi NCT03733756 | Shanghai Zhongshan Hospital | N/A |
| Unknown | Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associat NCT03404739 | Shanghai Zhongshan Hospital | Phase 2 / Phase 3 |
| Completed | Snare-assisted POEM for Treatment of Esophageal Achalasia NCT02999451 | First Affiliated Hospital, Sun Yat-Sen University | N/A |
| Unknown | Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal Achalasia NCT03012854 | Nanfang Hospital, Southern Medical University | N/A |
| Withdrawn | Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders NCT02663206 | Johns Hopkins University | N/A |
| Terminated | Achalasia Patient Reported Outcomes NCT02606578 | Mayo Clinic | — |
| Unknown | To Assess the Feasibility of Same Day Discharge Following a POEM Procedure NCT02572193 | McMaster University | N/A |
| Unknown | POEM for Spastic Esophageal Disorders NCT02425033 | University Health Network, Toronto | N/A |
| Recruiting | Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia NCT02518542 | Medical University of Vienna | N/A |
| Completed | Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders NCT03944863 | Société Française d'Endoscopie Digestive | — |
| Unknown | Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia NCT01750385 | Shanghai Zhongshan Hospital | N/A |
| Unknown | POEM vs. Pneumatic Dilation for Esophageal Achalasia NCT01768091 | Nanfang Hospital, Southern Medical University | N/A |
| Unknown | Comparison Study of Conventional POEM and Hybrid POEM for Esophageal Achalasia NCT01742494 | Shanghai Zhongshan Hospital | N/A |
| Unknown | Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia NCT01649843 | Shanghai Zhongshan Hospital | N/A |
| Unknown | Peroral Endoscopic Remyotomy for Failed Heller Myotomy NCT01637311 | Shanghai Zhongshan Hospital | N/A |
| Unknown | A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia NCT00188344 | University Health Network, Toronto | N/A |
| Completed | Laparoscopic Dor Versus Toupet Fundoplication for the Treatment of Idiopathic Esophageal Achalasia NCT00490750 | L. Michael Brunt | N/A |
| Recruiting | Esophageal Cancer Risk Registry NCT00260585 | University of Pittsburgh | — |
| Completed | Randomized Study of Botulinum Toxin Type A for Achalasia NCT00004416 | University of Texas | N/A |