NCT03733756

to Explore the Influence of Longitudinal Muscle on the Prognosis of Achalasia Patients After Peroral Endoscopic Myotomy (POEM)

to Explore the Influence of Longitudinal Muscle on the Prognosis of Achalasia Patients After Peroral Endoscopic Myotomy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 308 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Achalasia is a disease characterized by lack of peristalsis and lower esophageal sphincter failing to relax. Longitudinal muscle, outer layer of esophageal smooth muscle, is recently found to be responsible for emptying of esophagus for achalasia patients, especially for those type Ⅱcases. Clinical observations also conclude that type Ⅱ achalasia which still preserve longitudinal muscle response best to treatment, among the 3 types. Thus, with high frequent intraluminal ultrasound, clinically applied as endoscopic ultrasound, to measure the function of longitudinal muscle in achalasia patients, the current research aims to explore the influence of longitudinal muscle on the prognosis of achalasia patients after peroral endoscopic myotomy, a routine treatment.

Conditions

• Esophageal Achalasia

Interventions

Type	Name	Description
PROCEDURE	POEM preserving longitudinal muscle	participants are operated POEM only involving circular muscle, leaving longitudinal muscle intact
PROCEDURE	POEM involving longitudinal muscle	participants are operated POEM involving both circular and longitudinal muscle

Timeline

• Start date: 2019-01-01
• Primary completion: 2020-06-30
• Completion: 2020-08-31
• First posted: 2018-11-07
• Last updated: 2018-11-14

Locations

1 site across 1 country: China