| Not Yet Recruiting | Nanozymes in Endodontics NCT07518901 | University of Pennsylvania | Phase 4 |
| Recruiting | The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament NCT06207253 | British University In Egypt | Phase 2 / Phase 3 |
| Recruiting | A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients NCT07239505 | Fayoum University | N/A |
| Not Yet Recruiting | Postoperative Pain and Incidence of Extrusion Following the Use of Two Intra-canal Medications in Retreatment NCT06913673 | Minia University | Phase 2 |
| Recruiting | Exploration of the Utility of Dental-dedicated MRI for Dentistry NCT06948162 | Donald Nixdorf | — |
| Completed | Post Operative Sensitivity of MTA Obturation NCT06795282 | TC Erciyes University | — |
| Completed | Controlling Gag Reflex During Endodontic Diagnostic Radiography NCT07236138 | Qassim University | N/A |
| Recruiting | Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurg NCT06574152 | The University of Texas Health Science Center, Houston | N/A |
| Recruiting | Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication NCT06196515 | British University In Egypt | Phase 2 / Phase 3 |
| Recruiting | Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery NCT05935306 | University of Nove de Julho | N/A |
| Not Yet Recruiting | the Efficacy of Ginger Powder as an Analgesic for Intraoperative and Post- Endodontic Pain Management NCT06439212 | Cairo University | Phase 3 |
| Recruiting | Irrigation Activating Techniques on Irrigant Penetration Depth and Microbial Reduction NCT06660797 | Tanta University | N/A |
| Recruiting | Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication NCT06643663 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Unknown | Postural and Muscle Fatigue Analysis of Endodontic Residents NCT06282653 | Universidad Europea de Madrid | — |
| Completed | Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible NCT06304259 | October 6 University | N/A |
| Completed | Postoperative Pain in Endodontic Therapy NCT06741592 | Ordu University | N/A |
| Recruiting | Antimicrobial Efficacy of Nano-Based ICM on E.F NCT06533215 | Tanta University | N/A |
| Recruiting | Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing NCT06386991 | TC Erciyes University | Phase 4 |
| Unknown | Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion NCT06035185 | Istanbul Medipol University Hospital | — |
| Terminated | Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection NCT05959629 | University of Pennsylvania | N/A |
| Unknown | Treatment Outcome of Ortho MTA (BioMTA®) Cement vs AH Plus® Bioceramic Sealer (Dentsply). NCT05984940 | National University Hospital, Singapore | N/A |
| Completed | Post Operative Pain of Partial Pulpotomy Using a Bioceramic Material in Patients With Symptomatic Irreversible NCT05956613 | October 6 University | EARLY_Phase 1 |
| Not Yet Recruiting | Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Witho NCT05681754 | King's College London | N/A |
| Completed | Evaluation of Postoperative Pain After Single Visit Retreatment of Symptomatic and Asymptomatic Teeth NCT06357481 | Saglik Bilimleri Universitesi | N/A |
| Completed | Comparison of Clinical Outcomes Between GentleWave® and Biolase® NCT05555043 | University of North Carolina, Chapel Hill | N/A |
| Completed | Patients' Experiences During Endodontic Treatments Performed by Hospital Externs at the CHRU of Brest NCT05285176 | University Hospital, Brest | — |
| Completed | The 3-Dimensional Printed Guide in Endodontic Microsurgery NCT05283252 | Damascus University | N/A |
| Completed | Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment NCT05338671 | University of Washington | Phase 4 |
| Completed | Evaluation of Different Scaffolds in Regenerative Endodontic Treatment NCT06945965 | British University In Egypt | N/A |
| Completed | Revascularisation of Autotransplanted Teeth NCT05267249 | Medical University of Graz | — |
| Completed | Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles NCT04481945 | Misr International University | Phase 4 |
| Unknown | Effect of Music on Young Practitioner's Stress During Endodontic Treatment NCT04471558 | University Hospital, Brest | — |
| Completed | Volumetric Analysis of Resorption Types on CBCT NCT04617301 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Unknown | Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket NCT04399135 | Qassim University | N/A |
| Completed | Evaluation of Antimicrobial Efficacy and Postoperative Pain After Using Silver Nanoparticles and Chitosan Nano NCT06172023 | Minia University | N/A |
| Unknown | Guided Versus Conventional Periapical Endodontic Surgery NCT04133181 | Cairo University | N/A |
| Recruiting | Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer NCT04528979 | Juan Gonzalo Olivieri | N/A |
| Completed | Time Efficiency and Obturation Quality of Rotary Versus Manual in Primary Teeth NCT04102293 | Reem Mahmoud Abdelkader Awad | N/A |
| Unknown | Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth NCT04200638 | Universidad Autonoma de Baja California | N/A |
| Unknown | Impact of an Enhanced Sterile Protocol on Root Canal Treatment Outcome NCT03636087 | King's College London | N/A |
| Recruiting | Outcome of Endodontic Retreatment in One or Two Visits NCT04527705 | Universitat Internacional de Catalunya | N/A |
| Completed | Occurrence of Post-op Pain Following Gentlewave NCT03635515 | University of Minnesota | N/A |
| Withdrawn | Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment NCT03502135 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | Effect of Different Root Canal Instruments on Removal of Endotoxins From Necrotic Root Canals NCT03641612 | Heba Elasfouri | N/A |
| Terminated | N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization NCT03451435 | University of California, Los Angeles | EARLY_Phase 1 |
| Unknown | Outcome of Regenerative Endodontic Procedures NCT05612451 | King Abdullah University Hospital | N/A |
| Completed | Analysis of Bacterial Microbiome of Endodontically Infected Primary and Permanent Teeth NCT04211519 | Nuh Naci Yazgan University | N/A |
| Completed | 3D Analysis of Root Canal Conformation NCT03680534 | Institucion Universitaria Colegios de Colombia | N/A |
| Unknown | Clinical Outcomes of Bio-MA and ProRoot MTA in Endodontic Treatment NCT04243993 | Mahidol University | N/A |
| Completed | Comparison of Antibacterial Efficacy of Three Final Irrigants NCT03853200 | Dow University of Health Sciences | Phase 2 / Phase 3 |
| Completed | Post-endodontic Pain Survey NCT04462731 | Ya-Hsin Yu, DDS, MS | N/A |
| Completed | Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases NCT03042377 | Istanbul Medipol University Hospital | Phase 4 |
| Completed | Photodynamic Therapy in Endodontic Treatment NCT02824601 | Universidade Estadual Paulista Júlio de Mesquita Filho | Phase 2 |
| Completed | Effect of Platelet-Rich Plasma Biomembrane on Enhancing Bone Regeneration Following Endodontic Surgery NCT04109417 | Alexandria University | N/A |
| Completed | Retreat or Replace: Retrospective Investigation on a Cohort of Local Patients NCT06250114 | University of Bologna | — |
| Completed | Endodontic Root-canal Treatments Evaluated After Long-term Time NCT03215225 | University of Bologna | — |