NCT06207253

The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament

The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial

• Status: Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: British University In Egypt · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis. The main question\[s\] it aims to answer are: • Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.

Detailed description

The aim of the present study is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis. The evaluation is to be done using quantitative microbiological assessment from samples extracted from root canals before and after intracanal medicament placement in roots of permanent molars, having PAI score ≥ 2.

Conditions

• Endodontic Disease
• Pulp Disease, Dental
• Intracanal Medication

Interventions

Type	Name	Description
DRUG	Diclofenac Sodium	placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
DRUG	Calcium hydroxide	placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.

Timeline

• Start date: 2025-11-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2024-01-16
• Last updated: 2025-05-30

Locations

1 site across 1 country: Egypt