NCT06945965

Evaluation of Different Scaffolds in Regenerative Endodontic Treatment

Evaluation of Different Scaffolds in Regenerative Endodontic Treatment of Immature Non-Vital Permanent Teeth and Their Release of Growth Factors: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: British University In Egypt · Academic / Other
• Sex: All
• Age: 6 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate and compare the regenerative potentials of Injectable Platelet-Rich Fibrin (I-PRF), Platelet-Rich Fibrin (PRF), and Blood Clot (BC) as different scaffolds regarding: Radiographic outcomes (increase of root length, increase in thickness of dentinal wall, healing of periapical lesion, and apical closure). Clinical outcomes in the treatment of young, immature permanent teeth with necrotic pulps.

Conditions

• Endodontic Disease
• Regenerative Endodontics

Interventions

Type	Name	Description
PROCEDURE	Injectable platelet-rich fibrin (i-PRF) scaffold	The separated plasma and platelets form a light-yellow-colored layer, which is situated at the top of the tube. This is then aspirated using a syringe with a needle (partially active injectable form).
PROCEDURE	platelet-rich fibrin (PRF)scaffold	The fibrin clot was removed from the test tube with sterile tweezers, then cut into fragments, then placed incrementally in the canal space below the CEJ using hand pluggers (without prior induction of apical bleeding).
PROCEDURE	blood clot (BC) scaffold	A sterile saline-soaked cotton pellet was placed into the canal 2 mm below the orifice for 15 minutes to form a blood clot.

Timeline

• Start date: 2021-09-01
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2025-04-27
• Last updated: 2025-04-27

Locations

1 site across 1 country: Egypt