| Not Yet Recruiting | Outcomes of CTAK Surgery NCT07474870 | Stanford University | Phase 4 |
| Completed | KeratoConus Data Acquisition With Topography and Aberrometry NCT06859398 | Azalea Vision | N/A |
| Completed | Corneal Topographic Changes in Different Grades of OSA NCT06347900 | Sohag University | — |
| Completed | Refractive and Corneal Topographic Characteristics in Upper Egypt Children With High Cylinder NCT06348368 | Sohag University | — |
| Unknown | Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light NCT05027295 | Cornea and Laser Eye Institute | Phase 3 |
| Unknown | Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia NCT04905108 | Cornea and Laser Eye Institute | Phase 3 |
| Unknown | Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Image NCT04763785 | Insel Gruppe AG, University Hospital Bern | — |
| Unknown | Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulo NCT04897503 | Cornea and Laser Eye Institute | Phase 3 |
| Completed | Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution NCT04667572 | Cornea Associates of Texas | Phase 1 |
| Active Not Recruiting | Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism NCT04698590 | Cornea and Laser Eye Institute | N/A |
| Completed | Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics NCT04475900 | Technische Universität Dresden | — |
| Unknown | Safety and Effectiveness of the PXL-Platinum 330 System NCT04401865 | Colorado Eye Consultants/Cornea Consultants of Colorado | Phase 1 / Phase 2 |
| Completed | Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution NCT04177082 | Cornea Associates of Texas | Phase 1 |
| Recruiting | Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia NCT04094090 | Goodman Eye Center | Phase 2 |
| Completed | Cornea Ectasia Excimer Laser Treatment NCT04405882 | Bambino Gesù Hospital and Research Institute | — |
| Completed | Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients NCT05241145 | iVeena Delivery Systems, Inc. | Phase 1 / Phase 2 |
| Unknown | Evaluating Risk Factors of Post-LASIK Ectasia NCT03708575 | Assiut University | — |
| Completed | Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus NCT05691335 | Sohag University | N/A |
| Recruiting | Dresden Corneal Disease and Treatment Study NCT04251143 | Technische Universität Dresden | — |
| Completed | Corneal Tomographic Parameters in TGD NCT04433936 | Ameera Gamal Abdelhameed | — |
| Unknown | Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refrac NCT03319082 | Glaukos Corporation | — |
| Completed | Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia NCT03913338 | University Clinic Frankfurt | N/A |
| Unknown | Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2 NCT02009709 | Robert Mack, M.D. | Phase 1 |
| Unknown | Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL). NCT02883478 | Oslo University Hospital | Phase 1 / Phase 2 |
| Withdrawn | Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Sur NCT01643252 | Glaukos Corporation | Phase 3 |
| Terminated | Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refracti NCT01459679 | American-European Congress of Ophthalmic Surgery | Phase 3 |
| Unknown | Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia NCT01464268 | Cornea and Laser Eye Institute | Phase 3 |
| Unknown | UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia NCT01325298 | Mercy Center for Corrective Eye Surgery | Phase 2 |
| Unknown | Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic R NCT01152541 | Cornea and Laser Eye Institute | Phase 3 |
| Unknown | Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia NCT01112072 | Cornea and Laser Eye Institute | Phase 3 |
| Unknown | Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia NCT01123057 | Singapore National Eye Centre | N/A |
| Withdrawn | Corneal Crosslinking in Keratoconus and Corneal Ectasia NCT00679666 | Ohio State University | Phase 2 / Phase 3 |
| Completed | Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia NCT00567671 | Emory University | Phase 2 / Phase 3 |