NCT00679666

Corneal Crosslinking in Keratoconus and Corneal Ectasia

Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia

• Status: Withdrawn
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Ohio State University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Prospective, randomized, single site to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes progressive keratoconus or corneal ectasia.

Detailed description

After epithelial surface removal riboflavin drops are applied until there is saturation of the cornea.Then the UVA light is turned on to active the crosslinking process while drops are continued for the 30 minute of lamp use to replenish the riboflavin.

Conditions

• Progressive Keratoconus
• Corneal Ectasia

Interventions

Type	Name	Description
DRUG	Riboflavin	01% riboflavin drops for 30 minutes q 3 minutes before and during the procedure with exposure to UVA light for the second 30 minutes
DRUG	Placebo	Drops are given q 3 minutes before (30 minutes) and during the procedure (30 minutes) but without the use of UVA light. No activation of cross linking occurs.

Timeline

• Start date: 2008-04-01
• Primary completion: 2010-04-01
• Completion: 2010-10-01
• First posted: 2008-05-19
• Last updated: 2017-04-20

Locations

2 sites across 1 country: United States