| Not Yet Recruiting | A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderat NCT07076290 | Rise Therapeutics LLC | Phase 1 |
| Enrolling By Invitation | Study on Home Obstructive Respiratory Exacerbations NCT06544928 | Strados Labs, Inc. | — |
| Recruiting | Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease NCT05703919 | Central Denmark Region | Phase 4 |
| Completed | Assessing Optimal Inhaler Strategies During Acute Exacerbations of COPD (AECOPDs) Using Oscillometry NCT06495047 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Not Yet Recruiting | Study on Acupuncture Treatment of Chronic Airway Diseases(Asthma and Chronic Obstructive Pulmonary Disease) NCT06869525 | Henan University of Traditional Chinese Medicine | N/A |
| Enrolling By Invitation | The Italian Registry of Patients with Chronic Obstructive Pulmonary Disease NCT06652776 | University of Milan | — |
| Enrolling By Invitation | The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2 NCT06419062 | University of Strathclyde | — |
| Enrolling By Invitation | The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 1 NCT06419036 | University of Strathclyde | — |
| Recruiting | The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbatio NCT06274957 | Saglik Bilimleri Universitesi | N/A |
| Recruiting | Multiparametric Home Telemonitoring of Patients With Chronic Obstructive Pulmonary Disease Exacerbation NCT06331416 | University of Trieste | N/A |
| Completed | Is a Collective Person-centered Dialogue Intervention for Hospitalised COPD Patients Feasible? NCT06242301 | Hvidovre University Hospital | N/A |
| Unknown | Comparison of Bronchodilator Treatment Practices in Group E COPD Patients NCT06178068 | Ataturk University | N/A |
| Unknown | Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease NCT06211920 | Central Denmark Region | N/A |
| Completed | PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD NCT06160687 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Completed | RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection NCT06149494 | Altesa Biosciences, Inc. | Phase 2 |
| Unknown | Clopidogrel for the Prevention of Exacerbations in Severe COPD NCT06021990 | Lady Reading Hospital, Pakistan | Phase 3 |
| Unknown | Checklists Resuscitation Emergency Department NCT05649891 | Region Skane | N/A |
| Unknown | Comparing the Effects of Manual Hyperinflation and Diaphragmatic Proprioceptive Neuromuscular Facilitation on NCT06221033 | omar hasham mohamed | N/A |
| Unknown | Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Prev NCT05764993 | Rochester General Hospital | Phase 2 |
| Recruiting | Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting NCT05012033 | Imperial College London | — |
| Completed | CRP, Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD NCT06514599 | Kanuni Sultan Suleyman Training and Research Hospital | — |
| Recruiting | COPD-ICU Multicentre Prospective Observational Register NCT05734365 | Versailles Hospital | — |
| Terminated | Treatment of Pneumocystis in COPD (the TOPIC Study) NCT05418777 | Corewell Health East | Phase 1 / Phase 2 |
| Completed | A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chron NCT05400369 | Daiichi Sankyo | Phase 4 |
| Recruiting | Neuromuscular Electrical Stimulation in COPD/Community Acquired Pneumonia NCT05452226 | University of Vermont | N/A |
| Completed | Airway Inflammation, Small Airways Dysfunction, and Frequency of Exacerbations in COPD NCT06040931 | Mansoura University Hospital | N/A |
| Completed | Tolerance and Acute Effects of a New HFNT Nasal Cannula NCT05182294 | Temple University | N/A |
| Recruiting | The Reducing REVISITS Study: A Cluster RCT NCT05568043 | University of Chicago | N/A |
| Unknown | Study of Hospitalised Patients With Acute Respiratory Conditions NCT05095090 | University of Leicester | — |
| Completed | Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPD NCT05218525 | Aalborg University | N/A |
| Completed | ProAir Digihaler in COPD Disease Management: A Real World Study NCT04821869 | Pulmonary Research Institute of Southeast Michigan | — |
| Unknown | Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation o NCT04881409 | University of Leipzig | N/A |
| Completed | Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD NCT03984188 | University of Miami | Phase 3 |
| Unknown | Relationship Between Plasma Metabolome and the Efficacy of Systemic Glucocorticoid in AECOPD NCT04710849 | Peking University Third Hospital | — |
| Active Not Recruiting | Predictors of Acute Exacerbation in Patients With COPD - an Observational Study NCT04140097 | Schön Klinik Berchtesgadener Land | — |
| Completed | Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD NCT04879030 | Haiphong University of Medicine and Pharmacy | Phase 2 / Phase 3 |
| Completed | Identification of Patients Admitted With COPD Exacerbations and Predicting Readmission Risk Using Machine Lear NCT04192175 | University Health Network, Toronto | — |
| Unknown | Prednisone Reduction in ICU Patients With COPD Exacerbation NCT03981081 | Hôpital Universitaire Fattouma Bourguiba | Phase 4 |
| Completed | A Therapy for Improving Symptoms in Patients With Acute Exacerbations of COPD by Hydrogen-Oxygen Generator Wit NCT04000451 | Shanghai Asclepius Meditec Inc. | N/A |
| Completed | Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD NCT03661086 | Hvidovre University Hospital | N/A |
| Completed | Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD NCT03464695 | Hvidovre University Hospital | N/A |
| Completed | Effectiveness of Vibrating Mesh Versus Small Volume Nebuliser in Chronic Obstructive Pulmonary Disease (COPD) NCT03286855 | Beaumont Hospital | N/A |
| Unknown | Steroid Resistance During COPD Exacerbations With Respiratory Failure NCT03680495 | University of Colorado, Denver | — |
| Unknown | Impact of A. Lumbricoides on Pulmonary Aspergillosis Development NCT05783544 | Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan | N/A |
| Completed | Extracorporeal CO2 Removal in Acute Exacerbation of COPD Not Responding to Non-Invasive Ventilation NCT04882410 | Centre Hospitalier de Saint-Denis | — |