| Recruiting | Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surger NCT07340008 | University Medical Centre Ljubljana | N/A |
| Recruiting | High and Low Intensity Speech Intervention in Children With a Cleft Palate: Perceptions of Children, Their Car NCT06895395 | University Ghent | — |
| Recruiting | Evaluation of Maxillary Expansion Using Clear Aligners' Therapy in Patients With Cleft Lip and Palate at the M NCT06994754 | Cairo University | N/A |
| Recruiting | Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Pala NCT06381713 | University Ghent | N/A |
| Recruiting | Single Stage Versus Multiple Staged Repair of Nasal & Alveolar Deformities in Patients With Cleft Lip and Pala NCT06510881 | Assiut University | N/A |
| Not Yet Recruiting | The Effectiveness of Adhesive Versus Conventional Nasoalveolar Molding on Children With Unilateral Cleft Lip a NCT06451276 | Al-Azhar University | N/A |
| Not Yet Recruiting | Effect of Different Nasal Stent Designs With Nasoalveolar Molding Appliance NCT06411444 | Cairo University | N/A |
| Enrolling By Invitation | Book Sharing for Toddlers With Clefts NCT06338319 | Seattle Children's Hospital | N/A |
| Not Yet Recruiting | Patient Specific Implant Versus Miniplates for Advancement of Hypoplastic Maxilla NCT06292234 | Cairo University | N/A |
| Recruiting | Liposomal Bupivacaine Use in Alveolar Bone Graft Patients NCT06284434 | Kerry O'Rourke | Phase 3 |
| Recruiting | Phase I-IIa, to Evaluate the Safety, Feasibility, and Efficacy of the Use of BIOCLEFT in the Treatment of Clef NCT06408337 | Elisa María Cubiles Montero de Espinosa | Phase 1 / Phase 2 |
| Recruiting | Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral NCT06122805 | Children's Hospital Los Angeles | N/A |
| Unknown | Effectiveness of a Customized 3D Printed Nostril Retainer Combined With Taping Vs.Taping Only on Enhancing the NCT06211205 | Cairo University | N/A |
| Recruiting | Two Methods of Lip Taping as a Presurgical Orthopedic Appliance NCT05796336 | University of Baghdad | N/A |
| Unknown | Mindful Parenting - A Single Case Experimental Design Study NCT05779527 | Cardiff University | N/A |
| Recruiting | Effect of Performance-specific Cleft Speech Intervention and Long-term Learning in Children With a Cleft Palat NCT06105099 | University Ghent | N/A |
| Enrolling By Invitation | How Does Orthognathic Surgery Affect Jaw and Neck Motor Function? NCT05876169 | Umeå University | N/A |
| Completed | Challenges and Concerns Faced by Parents of Children With Cleft Lip and/or Palate NCT05730946 | Ain Shams University | — |
| Recruiting | PACT Programme for Parents of Children With SHCN NCT05467527 | Chinese University of Hong Kong | N/A |
| Completed | Perception of Appearance and Social Acceptance Between Cleft and Non-Cleft Children in Early Adolescence NCT06539572 | Chang Gung Memorial Hospital | — |
| Unknown | Alveolar Cleft Repair Using Osteoinductive Ceramics NCT05331456 | UMC Utrecht | N/A |
| Recruiting | Influence of Presurgical Orthodontic Molding on the Growth of Newborns With Unilateral Cleft Lip Palate NCT05081258 | University of Erlangen-Nürnberg | N/A |
| Unknown | Dental Age Estimation by Different Methods in Patients With Cleft Lip and Palate NCT05573295 | Istanbul University | — |
| Unknown | Assessment of Maxillary Arch Depth and Width in a Group of Surgically Repaired Unilateral Cleft Lip and Palate NCT04791813 | Cairo University | — |
| Recruiting | Test-Retest Reliability, Responsiveness and Interpretability of CLEFT-Q NCT05775679 | Department of Plastic and Reconstructive Surgery | — |
| Unknown | Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft NCT05971914 | Semmelweis University | N/A |
| Completed | Evaluation of the Effect of Prosthetic Management for Congenital Cleft Lip and Palate Infants on the Middle Ea NCT06075069 | Alexandria University | N/A |
| Recruiting | Ketorolac in Palatoplasty NCT04771156 | The University of Texas Health Science Center, Houston | Phase 4 |
| Unknown | Skeletal and Dental Maturational Stages in a Sample of Egyptian Subjects With Cleft Lip and Palate Deformity NCT05031039 | Cairo University | — |
| Recruiting | Use of Computer Aided Design and 3D Printing for Anesthesiology Management in a Pediatric Patient With Cleft F NCT04422847 | Brno University Hospital | N/A |
| Unknown | Slow Expansion and Protraction in Cleft Lip and Palate Patients NCT04997083 | Faculty of Dental Medicine for Girls | N/A |
| Unknown | Alt-RAMEC Expansion and Protraction by EDO in Cleft Lip and Palate Patient NCT04970095 | Faculty of Dental Medicine for Girls | N/A |
| Unknown | Rapid Maxillary Expansion and Protraction by Expander Differential Opening EDO in Cleft Lip and Palate Patient NCT05009472 | Faculty of Dental Medicine for Girls | N/A |
| Recruiting | Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate NCT04234971 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | The Effect of Bone Marrow Stem Cells Harvested from the Iliac Crest Versus Mandibular Ramus in Alveolar Cleft NCT06636643 | Faculty of Dental Medicine for Girls | — |
| Unknown | Short Term Efficiency of Presurgical Vacuum Formed Nasoalveolar Molding Aligners in Infants With Bilateral Cle NCT04966572 | Cairo University | N/A |
| Terminated | Fabrication of Naso-alveolar Molding (NAM) Appliance in Cleft Lip and Palate (CLP) From Digital Magnetic Reson NCT04369638 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Correlation Between Body Mass Index and Progressive Grafted Bone in Cleft Patients NCT05002920 | Chang Gung Memorial Hospital | — |
| Completed | Progression of Grafted Bone Density in Cleft Alveolus NCT04987190 | Chang Gung Memorial Hospital | — |
| Completed | National Treatment Approach Versus Standardized Treatment Protocol to Manage Patients With Cleft Lip and Palat NCT04696237 | Cairo University | — |
| Completed | The Effect of a Newly Designed Presurgical Orthopedic Appliance NCT05535530 | University of Baghdad | N/A |
| Unknown | Methods of Providing Information Prior to an Alveolar Bone Graft NCT04381078 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Completed | Three-dimensional Cleft Lip and Palate Morphology Prior to One-stage Cleft Repair NCT04616690 | University Hospital, Basel, Switzerland | — |
| Unknown | Augmented Reality (AR): The Future of "Patient Information Leaflets NCT04619030 | NHS Greater Glasgow and Clyde | N/A |
| Completed | Weigh Easy: Simplifying Home Weight Monitoring for Infants NCT04384276 | Children's Mercy Hospital Kansas City | N/A |
| Terminated | DynaCleft® Effects on Soft Tissues and on Quality of Life for Incomplete Unilateral Cleft Lip Infants NCT04455035 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Assessment of the Influence of Cleft Repair on Microcirculation of the Palate NCT03877666 | University Hospital, Basel, Switzerland | — |
| Completed | Effectiveness of Nasal-alar Elevator Combined With Taping Vs. Taping Alone on Improving the Nose Esthetics and NCT04331379 | Cairo University | N/A |
| Completed | Effectiveness of Two Maxillary Expanders in Improving the Transverse Skeletal and Dental Dimensions in Patient NCT04331977 | Cairo University | N/A |
| Unknown | Use of Computer Aided Design and 3D Printing for Anesthesiology Management in a Pediatric Patient With Cleft F NCT04422964 | Brno University Hospital | N/A |
| Unknown | Transverse Dento-skeletal Effects of Two Rapid Palatal Expansion Appliances in Cleft Lip and Palate Patients NCT04236466 | Cairo University | N/A |
| Unknown | MARPE in Patients With Cleft Lip and Palate NCT04354116 | Pontifícia Universidade Católica de Minas Gerais | N/A |
| Completed | Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair NCT03766217 | Hospital Sirio-Libanes | Phase 3 |
| Withdrawn | Oral Hygiene and Connected Toothbrush Before Alveolar Bone Graft for Cleft Lip and Palate NCT03750708 | Assistance Publique - Hôpitaux de Paris | N/A |
| Terminated | Evaluation of the Effects of LUNII on Pre-operative Anxiety and on the Post-operative Period in Children With NCT03740841 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Otologic and Rhinologic Outcomes in Children With Clef Palate NCT03708406 | University Hospital, Montpellier | — |
| Terminated | Three Dimensional Facial Growth Analysis NCT03514563 | University of Hull | — |
| Completed | Characterization of Cleft Lip and Palate Conditions in Guatemala NCT04725370 | Children's Hospital of Philadelphia | — |
| Unknown | the Relationship Between Cleft Lip and / or Palate (Different Types) and ABO Blood Groups. NCT03217890 | Cairo University | — |
| Completed | Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations NCT03395015 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infa NCT03011489 | Cairo University | N/A |
| Completed | Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/ NCT02881606 | Cairo University | N/A |
| Unknown | Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing NCT03065686 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Effect of Novel Nasoalveolar Molding Techniques on Parents' Satisfaction and Short Term Treatment Outcomes in NCT02845193 | Cairo University | N/A |
| Enrolling By Invitation | Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet) NCT02702869 | Duke University | — |
| Unknown | Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty NCT03839290 | Charles University, Czech Republic | — |
| Unknown | Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study NCT03165331 | Oslo University Hospital | N/A |
| Completed | Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular NCT03308266 | Pomeranian Medical University Szczecin | — |
| Completed | Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate NCT02789787 | University of Southern California | — |
| Completed | Periodontal Changes Following Mid Maxillary Distraction NCT03686761 | University of Alexandria | N/A |
| Completed | Tissue Engineered Constructs for Alveolar Cleft Repair NCT03563495 | Cairo University | N/A |
| Completed | Unilateral Cleft Repair in One Surgery With Pure Primary Healing NCT04108416 | University Hospital, Basel, Switzerland | — |
| Completed | Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients NCT01932164 | Hospital Sirio-Libanes | N/A |
| Unknown | One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy NCT01871623 | Chang Gung Memorial Hospital | N/A |
| Recruiting | Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate NCT01601171 | Centre Hospitalier Universitaire Vaudois | — |
| Completed | Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion NCT03976609 | Pontifícia Universidade Católica de Minas Gerais | — |
| Completed | Ultrasound Diagnosis of Cleft Lip and Palate NCT03582111 | University Hospital, Montpellier | — |
| Completed | Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? NCT00930124 | The University of Hong Kong | Phase 2 |
| Completed | Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate NCT00070811 | University of North Carolina, Chapel Hill | — |