NCT03065686

Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing

Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing GENEPIC

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Despite significant progress made in identification on numerous genes and gene pathways critical for craniofacial development, several approaches, ie mutation screening of specific candidates, association studies and even genome-wide scans have largely failed to reveal the molecular basis of NS human clefting

Detailed description

Despite significant progress made in identification on numerous genes and gene pathways critical for craniofacial development, several approaches, ie mutation screening of specific candidates, association studies and even genome-wide scans have largely failed to reveal the molecular basis of NS human clefting. Moreover, the efficiency of Whole Exome Sequencing -WES- was proven. The efficiency of WES was proven by the identification of the genes causing Freeman Sheldon and Miller's syndrome, followed by several others. In the Picardy region, management and follow-up of orofacial cleft patients are well-organised by a multidisciplinary team in the university hospital of Amiens. The investigators therefore decided to perform whole exome sequencing (WES) on precisely phenotyped non-syndromic CL/P patients followed in our center.

Conditions

• Cleft Lip and Palate

Interventions

Type	Name	Description
GENETIC	identification of genetic factors	Clinical questionnaire and analysis of genetic data obtained by exome high-throughput sequencing

Timeline

• Start date: 2016-11-30
• Primary completion: 2023-11-30
• Completion: 2023-11-30
• First posted: 2017-02-28
• Last updated: 2023-02-10

Locations

1 site across 1 country: France