NCT05002920

Correlation Between Body Mass Index and Progressive Grafted Bone in Cleft Patients

Correlation Between Body Mass Index and Progressive Bone Mineral Density in Cleft Patients After Secondary Alveolar Bone Grafting

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 39 (actual)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 8 Years – 10 Years
• Healthy volunteers: Not accepted

Summary

The cleft patients received alveolar bone graft(ABG) for alveolar defect. Body mass index (BMI) was measured for each patients when receiving ABG. Bone mineral density was measured by Cone-Beam CT at two time-points: post-ABG six months, and post-ABG two years. The study was to analyze the correlation between BMI and post-operative bone mineral density.

Detailed description

Although childhood obesity is a growing issue, the association between BMI and the progressive bone mineral density (BMD) in grafted tissue after secondar alveolar grafting (ABG) remains little reviewed. This study compared the correlation between BMI and the progressive BMD after ABG procedure. Thirty-nine patients with unilateral or bilateral clefts were enrolled. ABG was performed at mixed-dentition age. Patient were classified into underweight, normal weight, and overweight or obese based on age- and sex-adjusted BMI. BMD was expressed in Hounsfield unit (HU) on cone-beam computed tomography (CBCT), which was obtained at 6 months (T1) and 2 years (T2) postoperatively. Calibrated BMD (HUgrafted tissue/HUpogonion¬, BMDc) was used for further analysis.

Conditions

• Cleft Lip and Palate
• Bone Graft; Complications

Interventions

Type	Name	Description
PROCEDURE	alveolar bone grafting	the surgery of alveolar bone graft for alveolar defect in cleft patients

Timeline

• Start date: 2021-01-25
• Primary completion: 2021-06-02
• Completion: 2021-07-04
• First posted: 2021-08-12
• Last updated: 2021-08-12

Locations

1 site across 1 country: Taiwan