| Not Yet Recruiting | Biologics in Chronic Rhinosinusitis With Nasal Polyposis NCT06824649 | Medical University of South Carolina | Phase 4 |
| Not Yet Recruiting | Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis: NCT07151313 | Sinai University | N/A |
| Enrolling By Invitation | A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stap NCT07073664 | China-Japan Union Hospital | N/A |
| Completed | Clinical and Radiographic Evidence of Alleviation of Preoperative Chronic Sinusitis After Open Sinus Allogenei NCT06773494 | Misr International University | — |
| Completed | Sugammadex v.s. Neostigmine/Glycopyrrolate NCT06398899 | National Taiwan University Hospital | N/A |
| Unknown | Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms NCT06198894 | Zheng Liu | N/A |
| Unknown | Endotypic Stability in CRS NCT06272123 | Thomas Jefferson University | — |
| Completed | A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps NCT06036927 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Phase 2 |
| Unknown | Wound Healing After Endoscopic Sinus Surgery NCT06070311 | Assiut University | N/A |
| Unknown | A Clinical Study to Evaluate the Safety and Effectiveness of Novabel Bioabsorbable Steroid-releasing Stent for NCT06020690 | Enlight Medical Technologies (Shanghai) Co., Ltd | N/A |
| Unknown | Utility of Indocyanine Green Fluorescence in Endoscopic Sinonasal and Skull Base Surgery NCT04374448 | St. Paul's Sinus Centre | N/A |
| Unknown | Post-radiotherapy Rhinosinusitis in Children NCT05454163 | University Hospital, Lille | — |
| Unknown | Roflumilust in Chronic Rhinosinusitis With Nasal Polyposis. NCT05369039 | Menoufia University | Phase 2 |
| Completed | Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) NCT05295459 | Lyra Therapeutics | Phase 3 |
| Unknown | Efficacy of ArchSinus, NasoPore & Propel to Prevent Post-Surgical MT Lateralization and Improve Symptomatic Ou NCT05156801 | STS Medical | N/A |
| Completed | Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults NCT05219968 | Lyra Therapeutics | Phase 3 |
| Completed | LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study) NCT05035654 | Lyra Therapeutics | Phase 2 |
| Completed | Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery NCT04754230 | Stanford University | Phase 4 |
| Completed | Results of Endoscopic Sinus Surgery in Management of Ophthalmological Complications of Chronic Rhino Sinusitis NCT04617223 | Tanta University | N/A |
| Completed | The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyp NCT04852562 | Zheng Liu | N/A |
| Completed | Dupilumab in CRSsNP NCT04678856 | Sanofi | Phase 3 |
| Completed | Evolution of the Endonasal Microbiota in Patients With Chronic Rhinosinusitis NCT04418622 | University Hospital, Brest | — |
| Completed | Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) NCT04362501 | Johns Hopkins University | Phase 2 |
| Unknown | Eosinophils Endotypes in Chronic Airway Inflammatory Diseases NCT04187976 | University Hospital, Lille | — |
| Withdrawn | Comparison of Two Steroid Nasal Implants Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis NCT03729310 | Weill Medical College of Cornell University | EARLY_Phase 1 |
| Unknown | Assessing Improvement in Cognitive Deficit in CRS in Patients Treated With Medical Vs Surgical Management NCT04291118 | St. Paul's Hospital, Canada | N/A |
| Completed | Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS) NCT04163978 | Sanotize Research and Development corp. | Phase 2 |
| Withdrawn | Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates NCT03519061 | Kaiser Permanente | Phase 2 / Phase 3 |
| Unknown | The Feasibility of Using MRI During ESS NCT03903432 | Roee Landsberg | N/A |
| Completed | LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study) NCT04041609 | Lyra Therapeutics | Phase 2 |
| Completed | Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps NCT03358329 | Intersect ENT | Phase 3 |
| Unknown | Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis NCT03472144 | LifeBridge Health | Phase 3 |
| Terminated | Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children NCT03336671 | State University of New York - Upstate Medical University | N/A |
| Completed | 480 Biomedical Sinus Drug Depot NCT02967731 | Lyra Therapeutics | Phase 1 |
| Unknown | Radiologic Scoring of Patients With Chronic Sinusitis and Nasal Polyps NCT03174483 | Assiut University | N/A |
| Completed | Esmolol vs. Labetalol in Endoscopic Sinus Surgery NCT03661346 | The University of Texas Medical Branch, Galveston | Phase 2 |
| Withdrawn | Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure NCT02981017 | University of California, Los Angeles | N/A |
| Completed | In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia NCT02880514 | Intersect ENT | N/A |
| Unknown | Efficacy of Post-FESS Implantation of Composite Removable Sinus Stent to Prevent Post-Operative Complications NCT02812199 | STS Medical | N/A |
| Completed | The PIO (Propel In Office) III Study of In-office Placement of a Steroid-Eluting Implant Immediately Following NCT02687438 | ENT and Allergy Associates, LLP | N/A |
| Completed | The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus S NCT02562924 | University of Vermont Medical Center | N/A |
| Completed | Research on Identifying and Treatment Prognosis of Chronic Rhinosinusitis Based on Image and Sequencing Data NCT05983003 | Zheng Liu | — |
| Completed | S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps NCT02291549 | Intersect ENT | Phase 3 |
| Completed | Safety and Efficacy of the Propel Mini and Propel Nova Steroid-Eluting Sinus Implant in Frontal Sinus NCT02266810 | Intersect ENT | Phase 3 |
| Completed | Clinical Evaluation of Propel Nova Sinus Implant in Peripheral Sinus Ostia NCT02228720 | Intersect ENT | N/A |
| Withdrawn | Vitamin D Supplementation in Chronic Rhinosinusitis With Nasal Polyps NCT01185808 | Medical University of South Carolina | N/A |
| Completed | Safety and Performance of the Steroid-Releasing S8 Sinus Implant NCT01894503 | Intersect ENT | Phase 2 |
| Unknown | Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis NCT01854619 | Ondine Biomedical Inc. | N/A |
| Completed | Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps NCT01732536 | Intersect ENT | Phase 2 / Phase 3 |
| Completed | Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery NCT01706952 | Marc Tewfik | Phase 4 |
| Completed | Gulf War Illness Nasal Irrigation Study NCT01700725 | University of Wisconsin, Madison | Phase 2 |
| Completed | Efficacy and Safety of Two Dosages of a Herbal Medicinal Product (Dry Extract BNO 1016) in Chronic Rhinosinusi NCT01706484 | Bionorica SE | Phase 3 |
| Completed | Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery NCT01608308 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surg NCT01564355 | University of Calgary | N/A |
| Completed | Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients NCT01569048 | Yonsei University | Phase 4 |
| Completed | XprESS Maxillary Balloon Dilation Study NCT01525862 | Entellus Medical, Inc. | N/A |
| Completed | Randomized Evaluation of Maxillary Antrostomy Versus Ostial Dilation Efficacy Through Long-Term Follow-Up NCT01525849 | Entellus Medical, Inc. | N/A |
| Completed | Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis NCT01430026 | Mahidol University | — |
| Completed | Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis NCT01197612 | University of Michigan | Phase 3 |
| Completed | A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery NCT01253577 | Intersect ENT | Phase 3 |
| Completed | Vitamin D for Chronic Sinusitis NCT01007799 | University of Chicago | N/A |
| Completed | Clinical Study to Improve Diagnosis and Treatment of Sinusitis NCT00962689 | Ohio State University | — |
| Terminated | Effects of Endoscopic Sinus Surgery for Chronic Sinusitis on Asthma Control NCT01066416 | Endeavor Health | N/A |
| Completed | Xylitol Versus Saline in Chronic Sinusitis NCT00924404 | University of Iowa | N/A |
| Active Not Recruiting | Genetic Factors in Chronic Sinusitis NCT00880516 | University of Chicago | — |
| Unknown | The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery NCT00852410 | University of Toronto | Phase 3 |
| Completed | Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic NCT00912405 | Intersect ENT | N/A |
| Terminated | Sinusitis and Facial Pain Disorders Anti-Depression Trial NCT00754793 | University of Washington | Phase 4 |
| Withdrawn | Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery NCT00705354 | Lahey Clinic | N/A |
| Withdrawn | The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Sur NCT00671281 | University of Calgary | N/A |
| Withdrawn | Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study NCT00841802 | Northwestern University | Phase 4 |
| Completed | Balloon Sinus Dilation In Office or OR NCT00939393 | Integra LifeSciences Corporation | N/A |
| Completed | Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison NCT00626366 | University of Nebraska | N/A |
| Completed | A Clinical Evaluation of the Sinexus Intranasal Splint Following Functional Endoscopic Sinus Surgery in Patien NCT00840970 | Intersect ENT | N/A |
| Withdrawn | Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis NCT00603785 | University of California, San Francisco | Phase 4 |
| Completed | Safety and Efficacy of Balloon Sinuplasty in Pediatric Sinusitis NCT00939471 | Integra LifeSciences Corporation | N/A |
| Completed | Amphotericin B Suspension in Refractory Chronic Sinusitis NCT00425620 | Accentia Biopharmaceuticals | Phase 3 |
| Completed | Study of ONO-1078 in Patients With Chronic Sinusitis NCT00410735 | Ono Pharmaceutical Co., Ltd. | Phase 3 |
| Completed | Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis NCT00447837 | Naryx Pharma | Phase 2 |
| Withdrawn | Nasospore Stent For Use in Enodscopic Sinus Surgery NCT00671541 | Lahey Clinic | Phase 4 |
| Completed | Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR) NCT00231062 | Integra LifeSciences Corporation | Phase 3 |
| Terminated | Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Si NCT00140608 | Genzyme, a Sanofi Company | N/A |