NCT00852410

The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery

The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery: Randomized Clinical Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: University of Toronto · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.

Conditions

• Chronic Sinusitis

Interventions

Type	Name	Description
DRUG	1% lidocaine with 1:100,000 adrenaline	high dose
DRUG	1% lidocaine with 1:200,000 adrenaline	1% lidocaine with 1:200,000 adrenaline

Timeline

• Start date: 2009-03-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2009-02-27
• Last updated: 2010-06-30

Locations

1 site across 1 country: Canada