| Not Yet Recruiting | Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at Hi NCT07499999 | Dana-Farber Cancer Institute | Phase 2 |
| Recruiting | Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene NCT06817694 | CHU de Quebec-Universite Laval | N/A |
| Recruiting | Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy NCT06972719 | Duke University | N/A |
| Recruiting | BRCA Mutation Carriers' Platform a Multicenter Study NCT07253051 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Meta NCT06201234 | GBG Forschungs GmbH | Phase 2 |
| Recruiting | Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-neg NCT06488378 | Dana-Farber Cancer Institute | Phase 1 |
| Recruiting | Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer NCT05485766 | Okayama University | Phase 2 |
| Recruiting | A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies NCT06395519 | 858 Therapeutics, Inc. | Phase 1 / Phase 2 |
| Recruiting | Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors NCT06380660 | Acerand Therapeutics (Shanghai) Limited | Phase 1 / Phase 2 |
| Recruiting | Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors NCT06177171 | Pamela Munster | Phase 1 |
| Withdrawn | Chemo-free BRCA-targeted Neoadjuvant Strategy NCT05209529 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 2 |
| Recruiting | Contribution of Oncogenetics in Breast Cancer in Reunion Epidemiology of Breast Cancer in Reunion: Study of th NCT05898009 | Centre Hospitalier Universitaire de la Réunion | N/A |
| Recruiting | Combination Therapy in Cancers With Mutations in DNA Repair Genes NCT05694715 | University of California, San Francisco | Phase 1 |
| Recruiting | Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermedia NCT05498272 | Rana McKay, MD | Phase 2 |
| Recruiting | An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk a NCT05420064 | Memorial Sloan Kettering Cancer Center | N/A |
| Unknown | Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy NCT05448963 | Chang Gung Memorial Hospital | N/A |
| Active Not Recruiting | LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients NCT05410951 | European Institute of Oncology | — |
| Unknown | Longitudinal Sample Collection to Investigate Adaptation and Evolution of Ovarian High-grade Serous Carcinoma NCT05537844 | Liz-Anne Lewsley | — |
| Recruiting | FaCT Trial (Facilitated Cascade Testing Trial) NCT04613440 | Weill Medical College of Cornell University | N/A |
| Active Not Recruiting | Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening NCT04273542 | Centre Jean Perrin | N/A |
| Terminated | BrUOG 390: Neoadjuvant Treatment With Talazoparib NCT04598321 | Brown University | Phase 1 |
| Recruiting | SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells NCT04150042 | General Oncology, Inc. | Phase 1 |
| Completed | Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing NCT04683068 | European Institute of Oncology | N/A |
| Completed | A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer NCT04651920 | Lei Li | — |
| Unknown | Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian NCT04556071 | Xiaoxiang Chen | Phase 2 |
| Unknown | Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer NCT04566952 | Xiaoxiang Chen | Phase 2 |
| Completed | HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Br NCT03685331 | Abramson Cancer Center at Penn Medicine | Phase 1 |
| Completed | Surgical and Oncologic Outcomes After Robotic Nipple Sparing Mastectomy and Immediate Reconstruction NCT04108117 | Severance Hospital | — |
| Enrolling By Invitation | Genetic Education in BRCA Families NCT03544983 | Georgetown University | N/A |
| Completed | Evaluating Cascade Communication Methods NCT04428736 | University of Pennsylvania | — |
| Recruiting | Prostate Cancer Genetic Risk Evaluation and Screening Study NCT05129605 | Massachusetts General Hospital | — |
| Completed | Prospective Registry Trial for Single Port Robot-assisted Nipple Sparing Mastectomy (SPrNSM) NCT04866992 | University of Texas Southwestern Medical Center | — |
| Unknown | Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer NCT04190667 | Lei Li | — |
| Suspended | Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy NCT04151368 | University Health Network, Toronto | N/A |
| Active Not Recruiting | BRCA1/2 Flu Vaccine NCT04499534 | Abramson Cancer Center at Penn Medicine | — |
| Completed | Web-based Family History Tool NCT04890327 | Weill Medical College of Cornell University | N/A |
| Unknown | Efficacy of Platinum-based Chemotherapy in Platinum-resistant Ovarian Cancer) (EPITOC) NCT04055038 | Blokhin's Russian Cancer Research Center | Phase 2 / Phase 3 |
| Recruiting | Registry of Subjects at Risk of Pancreatic Cancer NCT04095195 | Associazione Italiana per lo Studio del Pancreas | — |
| Unknown | Health After eaRly Menopause Due to Oophorectomy NCT03835793 | The Netherlands Cancer Institute | — |
| Terminated | Functional Analysis of BRCAness NCT04780945 | Leiden University Medical Center | Phase 2 |
| Completed | The Genetic Education for Men Trial: Web-Based Education vs. Standard Care NCT02957981 | Georgetown University | N/A |
| Unknown | BRCA Main Home Nutritional Intervention-random Study NCT03570125 | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | N/A |
| Unknown | Abbreviated Breast MRI for Second Breast Cancer Detection in Women With BRCA Mutation Testing NCT03475979 | Seoul National University Hospital | — |
| Completed | Decision Support for BRCA Testing in Ethnically Diverse Women NCT03470402 | Columbia University | N/A |
| Active Not Recruiting | BRCA Founder OutReach (BFOR) Study NCT03351803 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Depression and Body Image Distress Following Mastectomy With Reconstruction NCT03428399 | Massachusetts General Hospital | — |
| Withdrawn | Combination of Carboplatin, Eribulin and Veliparib in Stage IV Cancer Patients NCT03032614 | The University of Texas Health Science Center at San Antonio | Phase 2 |
| Recruiting | Liquid Biopsy Evaluation and Repository Development at Princess Margaret NCT03702309 | University Health Network, Toronto | — |
| Completed | IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA) NCT04012229 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Management of Women With BRCA1/2 Mutation NCT03211611 | University Hospital, Montpellier | — |
| Completed | Magnetic Resonance Breast Tissue Characterisation to Improve Risk Stratification for Breast Cancer NCT03684733 | Royal Marsden NHS Foundation Trust | — |
| Completed | Pre-Salpingo-Oophorectomy Pilot Study of MAKO 7 Device Performance NCT02974842 | nVision Medical | — |
| Completed | Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers NCT03495609 | University Hospital, Ghent | Phase 4 |
| Completed | Dietary Intervention and BRCA Penetrance NCT03066856 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | N/A |
| Completed | Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction NCT01591746 | Mayo Clinic | Phase 3 |
| Active Not Recruiting | Radical Fimbriectomy for Young BRCA Mutation Carriers NCT01608074 | Centre Oscar Lambret | N/A |
| Active Not Recruiting | Endocrine Disruptors and Life STILe in Breast Cancer Development NCT05748353 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Withdrawn | 3.0 Tesla Magnetic Resonance Imaging for Breast Cancer Detection in High Risk Women NCT01409226 | NYU Langone Health | N/A |