NCT04651920

A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer

A Study on Association Between Homologous Recombination Genes and the Homologous Recombination Deficiency Status in Chinese Population With Epithelial Ovarian Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 240 (actual)
• Sponsor: Lei Li · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: —

Summary

The association between homologous recombination (HR) gene mutations and homologous recombination deficiency (HRD) status in Chinese epithelial ovarian cancer (EOC) patients is little known. This study would recruit 400 Chinese EOC patients with known targeted gene mutations via a multi-panel testing of 27 genes, including BRCA1/BRCA2. All patients accept evaluation of HRD model, which is based on the loss of heterozygosity (LOH), telomere allele imbalance (TAI) and large-scale state transitions (LST). The mutated genes, HRD score model and their relationship with the prognosis, would provide a full description of for the Chinese EOC patients, and a potential explanation of platinum-resistance in such population.

Conditions

• Epithelial Ovarian Cancer
• Chinese
• Homologous Recombination Deficiency
• BRCA1 Mutation
• BRCA2 Mutation
• Prognosis
• Homologous Recombination Genes

Interventions

Type	Name	Description
GENETIC	Evaluation of homologous recombination deficiency score	Evaluation of homologous recombination deficiency score which is based on the loss of heterozygosity (LOH), telomere allele imbalance (TAI) and large-scale state transitions (LST)

Timeline

• Start date: 2020-11-26
• Primary completion: 2022-03-26
• Completion: 2022-03-26
• First posted: 2020-12-03
• Last updated: 2022-03-29

Locations

1 site across 1 country: China