| Not Yet Recruiting | Study Comparing Neoadjuvant Versus Adjuvant Stereotactic Radiotherapy of Brain Metastases NCT07437820 | GCS Ramsay Santé pour l'Enseignement et la Recherche | N/A |
| Active Not Recruiting | Local Treatment Strategies for Brain Metastases of Colorectal Cancer NCT07448662 | Blokhin's Russian Cancer Research Center | — |
| Not Yet Recruiting | Tarlatamab for SCLC Brain Metastases NCT07402343 | Maastricht University Medical Center | Phase 2 |
| Recruiting | Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment Wi NCT07132190 | Ayal A. Aizer, MD | Phase 2 |
| Recruiting | Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brai NCT07130786 | Ayal A. Aizer, MD | Phase 2 |
| Not Yet Recruiting | Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcolo NCT06974370 | University of Vermont Medical Center | Phase 2 |
| Recruiting | Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases NCT06620380 | University of Zurich | Phase 2 |
| Recruiting | AI-assisted Diagnosis of Malignant Brain Tumors NCT07198256 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Withdrawn | A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases NCT05620914 | Mustafa Khasraw, MBChB, MD, FRCP, FRACP | Phase 2 |
| Recruiting | Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases NCT06401824 | Maastricht University Medical Center | Phase 2 |
| Not Yet Recruiting | BEAT-Breast: Trial of DE-iPTV in Patients With Primary Breast Cancer With Brain Metastases Who Are Not Suitabl NCT06611306 | Imperial College London | N/A |
| Withdrawn | JDQ443 for KRAS G12C NSCLC Brain Metastases NCT05999357 | Maastricht University Medical Center | Phase 2 |
| Recruiting | 18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery NCT06048094 | Baptist Health South Florida | Phase 1 |
| Recruiting | Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer NCT06449989 | Blokhin's Russian Cancer Research Center | — |
| Recruiting | a Feasibility Study of iHD-SRT for BM NCT06231186 | Ruijin Hospital | N/A |
| Active Not Recruiting | A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors NCT06209567 | Memorial Sloan Kettering Cancer Center | EARLY_Phase 1 |
| Recruiting | Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases NCT05789589 | Baptist Health South Florida | Phase 1 / Phase 2 |
| Recruiting | Multi-disciplinary Care for Brain Metastases NCT06280300 | University of Vermont Medical Center | N/A |
| Recruiting | Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Meta NCT06047379 | Neonc Technologies, Inc. | Phase 1 / Phase 2 |
| Recruiting | SILibinin in NSCLC and BC Patients With Single Brain METastasis (SILMET) NCT05689619 | A.O.U. Città della Salute e della Scienza | N/A |
| Unknown | Stereotactic Radiotherapy Management of Brain Metastases: the Value of a Longitudinal Multimodal Approach (POS NCT06029140 | University Hospital, Brest | — |
| Active Not Recruiting | Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunother NCT05703269 | Wake Forest University Health Sciences | N/A |
| Active Not Recruiting | Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin NCT05793489 | Istituto Clinico Humanitas | N/A |
| Recruiting | Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases NCT05545007 | Istituto Clinico Humanitas | N/A |
| Recruiting | Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors NCT05480644 | Duke University | — |
| Suspended | Keto-Brain:Investigating the Use of Ketogenic Diets in Brain Metastases NCT05428852 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment NCT05559853 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Fractionated Stereotactic Radiotherapy for Limited Small Volume Brain Metastases NCT07405047 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Recruiting | Trial of Preoperative Radiosurgery Versus Postoperative Stereotactic Radiotherapy for Resectable Brain Metasta NCT05124236 | Susanne Rogers | N/A |
| Recruiting | RAPid SimPLE Targeted Radiation Treatment for Brain Metastases NCT05050929 | British Columbia Cancer Agency | Phase 2 |
| Recruiting | A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain NCT05419076 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radio NCT04689048 | Baptist Health South Florida | Phase 1 |
| Completed | Managing Distress in Malignant Brain Cancer NCT05087095 | Virginia Commonwealth University | N/A |
| Recruiting | Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therap NCT04711824 | Colette Shen | Phase 1 / Phase 2 |
| Terminated | Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy NCT04567251 | Duke University | — |
| Active Not Recruiting | A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases NCT05341739 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Active Not Recruiting | Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases NCT05012254 | Fundación GECP | Phase 2 |
| Recruiting | Brain Imaging Biomarkers in Patients With Brain Metastasis NCT04197297 | University Health Network, Toronto | Phase 2 |
| Unknown | Stereotactic Radiosurgery vs Whole Brain Radiotherapy in Breast Cancer With Brain Oligometastasis NCT05144867 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 3 |
| Completed | Exploring Compensation to Maintain Cognitive Function in Adults Newly Diagnosed With Brain Cancer NCT04075370 | Duke University | — |
| Unknown | Re-TREAT: Re-irradiation for Relapsed Brain Metastases NCT05126875 | Rigshospitalet, Denmark | N/A |
| Terminated | Accelerated Checkpoint Therapy for Any Steroid Dependent Patient With Brain Metastases NCT04461418 | AHS Cancer Control Alberta | Phase 2 |
| Recruiting | A Neurocognitive Study in Patients With Brain Oligometastases Receiving Hypofractionated SRT NCT04805255 | Chang Gung Memorial Hospital | — |
| Completed | Safety Study of Pritumumab in Brain Cancer NCT04396717 | Nascent Biotech | Phase 1 |
| Unknown | Multi -paramEtric Imaging to Assess Treatment REsponse After Stereotactic Radiosurgery of Brain Metastases NCT04626206 | Royal Marsden NHS Foundation Trust | — |
| Terminated | Neoadjuvant Immunotherapy in Brain Metastases NCT04434560 | Sarah Sammons, MD | Phase 2 |
| Recruiting | Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases NCT04397978 | Universitaire Ziekenhuizen KU Leuven | — |
| Active Not Recruiting | Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosur NCT04785521 | IRCCS San Raffaele | — |
| Terminated | LITT and Pembrolizumab in Recurrent Brain Metastasis NCT04187872 | University of Florida | Phase 1 |
| Terminated | Focal Intraoperative Radiotherapy of Brain Metastases NCT03789149 | AC Camargo Cancer Center | Phase 2 |
| Recruiting | UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases NCT04343157 | Jona Hattangadi-Gluth | Phase 2 |
| Recruiting | The Cohort for Patient-reported Outcomes, Imaging and Trial Inclusion in Metastatic BRAin Disease (COIMBRA) NCT05267158 | UMC Utrecht | — |
| Unknown | Radiotherapy of Multiple Brain Metastases Using AGuIX® NCT03818386 | University Hospital, Grenoble | Phase 2 |
| Unknown | Revision of the EORTC QLQ-BN20 Questionnaire NCT04689321 | Leiden University Medical Center | — |
| Completed | Stereotactic Radiotherapy of the Resection Cavity of Brain Metastases vs. Post-operative Whole-brain Radiother NCT03285932 | Juergen Debus | Phase 2 |
| Completed | Comparaison Between MRI Alone or Combined With Positron Emission Tomography for Brain Metastasis Diagnosis NCT05095766 | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | — |
| Completed | Combining Radiosurgery and Nivolumab in the Treatment of Brain Metastases NCT02978404 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 2 |
| Completed | SIMT Stereotactic Radiosurgery Outcomes Study NCT02886572 | Duke University | N/A |
| Completed | Hypofractionated Brain Radiationcavity NCT03561896 | Oncology Institute of Southern Switzerland | N/A |
| Completed | Intrafractional Head Movement During Radiosurgery NCT03896555 | Medical University Innsbruck | — |