NCT04397978

Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To observe the quality of life (QOL) and to report on toxicity and outcome parameters after the (repeated) use of local ablative therapy (LAT) i.e. stereotactic radiotherapy (SRT) for patients with multiple (4-10) brain metastases

Detailed description

Phase IV prospective non-randomized observational trial (registry trial) for patients with a DS-GPA \> 1.5 or an estimated life expectancy of \>3 months and an established diagnosis on dedicated brain MRI of 4-10 BM of any solid primary tumor. We plan to deliver a local ablative therapy (LAT) i.e. SRT in 1 to 5 fractions on visible BM and post-surgical cavities if applicable. Our primary aim is to provide quality of life (QOL) data and our secondary aim is to report on several toxicity and outcome parameters for this patient cohort.

Conditions

• Brain Metastases, Adult

Interventions

Type	Name	Description
RADIATION	Stereotactic radiotherapy	Local ablative therapy with SRT

Timeline

• Start date: 2020-10-10
• Primary completion: 2025-06-01
• Completion: 2025-06-01
• First posted: 2020-05-21
• Last updated: 2024-07-01

Locations

1 site across 1 country: Belgium