| Not Yet Recruiting | Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study NCT04387305 | Daniel Nishijima, MD, MAS | Phase 3 |
| Recruiting | NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury NCT06584591 | Kessler Foundation | N/A |
| Recruiting | Automated Robotic TCD in Traumatic Brain Injury NCT05848297 | Virginia Commonwealth University | — |
| Enrolling By Invitation | The DIAGNOSE CTE Research Project-II NCT06860828 | Boston University | — |
| Not Yet Recruiting | The Value of Combined Detection of Different Blood Biomarkers in the Diagnosis and Treatments of Traumatic Bra NCT06854835 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Active Not Recruiting | Early Myofascial Manual Treatment in Subjects With Spasticity Following Acquired Brain Injury NCT06898242 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Not Yet Recruiting | Biomarkers of Traumatic Brain Injury With Tbit System NCT04107662 | BioDirection Inc | — |
| Recruiting | Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric) NCT06413173 | United States Naval Medical Center, San Diego | N/A |
| Not Yet Recruiting | Evaluation of EEG Power Spectrum in Patients With Traumatic Coma NCT06321146 | RenJi Hospital | — |
| Completed | Correlation Patterns of Brain Temperature-Pressure in Acute Brain Injury NCT06101537 | Beijing Tiantan Hospital | — |
| Unknown | Predictors of Mortality in Traumatic Brain Injury Patients in Intensive Care Unit NCT06183749 | Umraniye Education and Research Hospital | — |
| Terminated | Antiseizure Medication in Seizure Networks at Early Acute Brain Injury NCT06081283 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | The Effects of Lifebloom One on Physical Activity After Acquired Brain Injury NCT05977270 | Lifebloom | N/A |
| Enrolling By Invitation | Longitudinal Assessment of Post-concussion Driving in Young Adults NCT05942638 | University of Georgia | — |
| Recruiting | mTBI Identification and Monitoring Through Retinal Scanning NCT06142435 | Rebiscan, Inc. | — |
| Completed | The Feasibility of Home-Based Measurement of Circadian Timing for Veterans With TBI and Insomnia NCT05665764 | VA Office of Research and Development | — |
| Completed | Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial NCT05632627 | University of Colorado, Denver | Phase 2 |
| Unknown | Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury NCT05778123 | RenJi Hospital | — |
| Unknown | Assignment of the Verbal Component Score and Addition of Pupil Reaction to the Glasgow Coma Scale NCT05767502 | Uludag University | — |
| Unknown | Glutamine and Traumatic Brain Injury NCT05569993 | Assiut University | EARLY_Phase 1 |
| Completed | Brain Oximeter Calibration and Validation Study NCT05397704 | Cyban Pty Ltd | N/A |
| Unknown | Use of Cerebral Biomarkers in Minor Traumatic Brain Injury in the Emergency Unit NCT06069674 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Brain Injury Education and Outpatient Navigation-1stBIEN NCT05261477 | Seattle Children's Hospital | N/A |
| Unknown | Prognostic Value of Pediatric GCS-Pupil Score in Pediatric Patients With Traumatic Brain Injury NCT05419739 | Uludag University | — |
| Completed | Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner (MOBI-1) NCT04893837 | University of Alabama at Birmingham | — |
| Active Not Recruiting | HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) -Post-Traumatic Epilepsy (PTE) NCT05235061 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Acute Intermittent Hypoxia in Traumatic Brain Injury NCT04890639 | Shirley Ryan AbilityLab | N/A |
| Recruiting | The HOME Program for Individuals With Traumatic Brain Injury and Family Members NCT05117619 | Villanova University | N/A |
| Active Not Recruiting | Head and Intraocular Trauma Tool for the Identification of Mild Traumatic Brain Injury NCT05092295 | Rebiscan, Inc. | — |
| Completed | Estimating Highest Capacity Performance During Evaluation of Walking for Individuals With Traumatic Brain Inju NCT05057377 | The University of Texas Medical Branch, Galveston | — |
| Recruiting | Ketamine in Acute Brain Injury Patients. NCT05097261 | Geert Meyfroidt, MD, PhD | Phase 4 |
| Unknown | Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers NCT04666766 | Region Skane | N/A |
| Active Not Recruiting | HITT for the Identification of Mild Traumatic Brain Injury NCT05092282 | Rebiscan, Inc. | — |
| Completed | Traumatic Brain Injury and the Gut Microbiome NCT04949607 | Centre for Neuro Skills | N/A |
| Enrolling By Invitation | Wellness and Quality of Life Perceptions of People With Traumatic Brain Injury NCT04794894 | Quality Living, Inc. | — |
| Active Not Recruiting | Mobile Subthreshold Exercise Program for Concussion--R01 NCT04688255 | Seattle Children's Hospital | N/A |
| Completed | Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families NCT04584554 | Duke University | N/A |
| Unknown | Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Bri NCT04710550 | Massachusetts General Hospital | Phase 1 |
| Completed | tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study NCT04925453 | United States Naval Medical Center, San Diego | N/A |
| Completed | Determining the Incidence of Vestibular Dysfunction in Traumatic Brain Injury Patients NCT04592575 | Shirley Ryan AbilityLab | — |
| Completed | Visual Feedback in Lower Limb Rehabilitation NCT05179330 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | GOALS Cognitive Training Delivered to Aging Veterans in Person or Via Telehealth NCT04111549 | VA Office of Research and Development | N/A |
| Unknown | The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury NCT04515420 | University Medical Centre Ljubljana | — |
| Withdrawn | Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI) NCT02776488 | University of California, Los Angeles | Phase 2 |
| Active Not Recruiting | Gait Training Through a Novel Over-ground Wearable Robotic System in People with Pyramidal Hemisyndromes NCT04559724 | IRCCS San Raffaele Roma | N/A |
| Completed | Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury NCT04221009 | VA Office of Research and Development | N/A |
| Recruiting | Buspirone and Melatonin for Depression Following Traumatic Brain Injury NCT04400266 | Massachusetts General Hospital | Phase 4 |
| Completed | Therapy of Pragmatic Disorders in Brain-damaged Individuals NCT04708561 | University of Neuchatel | N/A |
| Completed | Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents NCT04288167 | Medicortex Finland Oy | N/A |
| Unknown | Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children NCT04540445 | Children's Hospital of Orange County | — |
| Completed | Telehealth Pain Self-Management for Employed Adults NCT04248725 | University of Washington | N/A |
| Terminated | Platelet Bioenergetics in TBI NCT04271059 | Kevin Hatton | — |
| Unknown | Assessment Effectiveness of the Leap Motion Capture® System on the Functionality of the Upper Limb in Acquired NCT04166617 | Universidad Rey Juan Carlos | N/A |
| Unknown | The Role of MEG in Assessment and Diagnosis In mTBI NCT03867513 | University of Nottingham | — |
| Unknown | Theta Burst Stimulation for Headaches After Traumatic Brain Injury NCT04906603 | Minneapolis Veterans Affairs Medical Center | N/A |
| Withdrawn | Remote Ischemic Conditioning in Traumatic Brain Injury NCT03899532 | University of Arizona | N/A |
| Recruiting | Brain Oxygen Optimization in Severe TBI, Phase 3 NCT03754114 | University of Michigan | N/A |
| Completed | Meta-Analysis Accidental Hypothermia in Trauma NCT04332237 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Treating Persistent Post-concussion Symptoms With Exercise NCT03895450 | University of Calgary | N/A |
| Terminated | The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain I NCT03900182 | Hung-Chen Wang | N/A |
| Completed | Traumatic Brain Injury Positive Strategies NCT03867968 | University of Oregon | N/A |
| Completed | Medical and Resource Facilitation Intervention After Traumatic Brain Injury NCT03429322 | Mayo Clinic | N/A |
| Completed | Nutritional and Metabolic Biomarkers in Prediction of Outcomes After Traumatic Brain Injury: a Patient Cohort NCT04718935 | Seoul National University Hospital | — |
| Completed | Intervention to Change Attributions That Are Negative (ICAN) NCT03648476 | Indiana University | N/A |
| Unknown | Management and Outcomes Following Emergency Surgery for Traumatic Brain Injury NCT04212754 | University of Cambridge | — |
| Recruiting | Online Memory Intervention for Individuals with Traumatic Brain Injury NCT04331392 | Toronto Rehabilitation Institute | N/A |
| Completed | Efficacy of Repetitive Transcranial Magnetic Stimulation for Improvement of Memory in Older Adults With TBI NCT03727737 | Palo Alto Veterans Institute for Research | N/A |
| Completed | Validation of Brain Function Assessment Algorithm for mTBI/Concussion NCT03671083 | BrainScope Company, Inc. | — |
| Completed | REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness NCT03504709 | Massachusetts General Hospital | — |
| Completed | Thromboelastometry-identified Haemostatic Changes in Isolated Traumatic Brain Injury NCT03616808 | Lithuanian University of Health Sciences | N/A |
| Completed | Diagnosis of mTBI in a Community Setting NCT03539848 | University of Miami | N/A |
| Completed | TBI Care: Collaborative Care for Pain After Traumatic Brain Injury (TBI) NCT03523923 | University of Washington | N/A |
| Completed | Objective Brain Function Assessment of mTBI/Concussion NCT03963804 | BrainScope Company, Inc. | — |
| Recruiting | Validation of the Scandinavian Guidelines for Minor and Moderate Head Trauma in Children NCT05964764 | Halmstad County Hospital | — |
| Unknown | Outcomes of Traumatic Brain Injury and External Validation of CRASH Prognostic Model NCT03932500 | Seth Gordhandas Sunderdas Medical College | — |
| Withdrawn | Testing Mild Traumatic Brain Injury (mTBI) in Diverse Athletic Groups NCT03515967 | University of Miami | N/A |
| Completed | CPPopt Guided Therapy: Assessment of Target Effectiveness NCT02982122 | Maastricht University Medical Center | N/A |
| Completed | Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation NCT03464175 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Unknown | The Effects of Acupuncture on the Risk of AD After TBI NCT03378037 | China Medical University Hospital | N/A |
| Completed | Effect of Prebiotic Fiber- Enriched (scFOS) Enteral Feeding on the Microbiome in Neurological Injury Trauma Pa NCT03153397 | Duke University | N/A |
| Completed | HITT Device Pilot Testing for Traumatic Brain Injury NCT03249818 | Rebiscan, Inc. | N/A |
| Completed | Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury NCT03169647 | Kessler Foundation | N/A |
| Recruiting | Morning Bright Light to Improve Sleep Quality in Veterans NCT03578003 | Portland VA Medical Center | N/A |
| Completed | Usability and Tolerability of Novel Protection Device Against Potential Brain Injury During Competitive Sport NCT03318822 | Emory University | — |
| Unknown | A Trial Evaluating Effects of COMT Inhibition in Patients With Acquired Brain Injury NCT03273062 | Sheppard Pratt Health System | Phase 2 |
| Completed | Effects of PSTon Mental Health Outcomes in Caregivers of Post-9/11 Combat Veterans With a Traumatic Brain Inju NCT03211884 | Duquesne University | N/A |
| Completed | Home-based Arm and Hand Exercise to Improve Upper Limb Function After Traumatic Brain Injury NCT03401645 | Kessler Foundation | N/A |
| Unknown | Evaluation of a Novel Gait Training Device to Support Body Weight NCT03171207 | Lite Run Inc. | N/A |
| Completed | rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the NCT03691272 | University of Calgary | Phase 1 / Phase 2 |
| Unknown | A Multidimensional Inpatient Balance Training Class to Improve Functional Outcomes in Rehabilitation Inpatient NCT03110237 | University of British Columbia | N/A |
| Completed | Interventions for Parent Caregivers of Injured Military/Veteran Personnel NCT03309046 | Memphis VA Medical Center | N/A |
| Active Not Recruiting | Mild TBI Assessment & Rehabilitation NCT02920788 | VA Office of Research and Development | N/A |
| Unknown | Postoperative Temperature Monitoring In Brain Trauma NCT03068143 | RenJi Hospital | — |
| Completed | Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes NCT02957461 | BrainScope Company, Inc. | — |
| Completed | A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury NCT03810222 | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS | — |
| Completed | Combined Cognitive and Vocational Interventions After Mild-to-moderate TBI: a Randomized Controlled Trial NCT03092713 | Oslo University Hospital | N/A |
| Completed | Application of Early Goal-directed Sedation in Patients With Severe Brain Injury NCT04525482 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Active Not Recruiting | Autologous Stem Cell Study for Adult TBI (Phase 2b) NCT02525432 | The University of Texas Health Science Center, Houston | Phase 2 |
| Unknown | Improving Medication Self-Administration and Health After Brain Injury NCT03885674 | Kessler Foundation | N/A |
| Completed | Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury NCT02754063 | University Hospital, Grenoble | N/A |
| Completed | Objective Brain Function Assessment of mTBI/Concussion in High School Athletes NCT02661633 | BrainScope Company, Inc. | — |
| Completed | Beta Blockade in in Traumatic Brain Injury NCT02957331 | University of Tennessee | Phase 4 |
| Unknown | Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury NCT02645552 | RenJi Hospital | Phase 3 |
| Completed | The Clinical Relevance of Micro RNAs in Mild Traumatic Brain Injury NCT02639923 | Harald Wolf, MD | — |
| Withdrawn | Cognitive Rehabilitation and Brain Activity of Attention Control in TBI NCT02589509 | VA Office of Research and Development | N/A |
| Unknown | Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With BI and NCD NCT02652598 | Sheppard Pratt Health System | Phase 2 |
| Completed | Treatment and Recovery Monitoring of Post TBI Symptoms NCT02426749 | University of Manitoba | N/A |
| Completed | Objective Brain Function Assessment of mTBI/Concussion in College Athletes NCT02477943 | BrainScope Company, Inc. | — |
| Unknown | Safe@Home: A Self-Management Program for Individuals With TBI and Their Families NCT02893345 | Shepherd Center, Atlanta GA | Phase 2 |
| Unknown | Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia NCT02792985 | Institut Guttmann | N/A |
| Completed | Digital Gaming for Persons With Traumatic Brain Injury NCT02425527 | University of Turku | N/A |
| Terminated | Characterization of Human Autoantibody Titers After Central Nervous System Insult NCT03089749 | University of Utah | — |
| Completed | Recovery Enhancement From Traumatic Brain Injury Using Acceptance and Commitment Therapy - a Pilot Study. NCT02337114 | University of Glasgow | EARLY_Phase 1 |
| Completed | Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury NCT02158494 | University of Wisconsin, Madison | N/A |
| Completed | Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans NCT01336413 | VA Office of Research and Development | Phase 2 |
| Completed | CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe NCT02004080 | Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva | — |
| Completed | Training Executive Functions to Facilitate Recovery Following Traumatic Brain Injury NCT01993407 | Kessler Foundation | N/A |
| Completed | Safety Study of NNZ-2566 in Healthy Subjects, Following Oral Administration NCT01420042 | Neuren Pharmaceuticals Limited | Phase 1 |
| Completed | INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI) NCT01554891 | INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium | — |
| Completed | The EPIC Project: Impact of Implementing the EMS Traumatic Brain Injury Treatment Guidelines NCT01339702 | University of Arizona | — |
| Completed | AcuSleep in Mild Traumatic Brain Injury (TBI) NCT01162317 | VA Office of Research and Development | N/A |
| Completed | Walking and Balance Post-TBI NCT01418976 | INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium | N/A |
| Completed | Patient Participation Beliefs and Post-Traumatic Stress Disorder (PTSD) NCT01419223 | INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium | — |
| Unknown | How Well do Patients With Traumatic Brain Injury Learn New Material Using Learning Styles in Online Science Cl NCT01417468 | Center for Vision Development, New Market, Maryland | N/A |
| Completed | Biomarkers of Mild and Moderate Traumatic Brain Injury NCT01295346 | Banyan Biomarkers, Inc | — |
| Completed | Brain Injury Biomarkers in the General Population NCT01786460 | Banyan Biomarkers, Inc | — |
| Terminated | Biomarkers of Brain Injury: Magnitude and Outcome of Mild and Moderate TBI NCT01786447 | Banyan Biomarkers, Inc | — |
| Completed | The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury NCT00987688 | Australian and New Zealand Intensive Care Research Centre | N/A |
| Completed | Safety Study of NNZ-2566 in Healthy Female Subjects NCT00961779 | Neuren Pharmaceuticals Limited | Phase 1 |
| Terminated | Pre-hospital and Intra-hospital Temporal Delays in Patients Requiring Emergent Trauma Craniotomy NCT02803112 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Clinical Utility of Olfactory Rehabilitation: Treatment for Pacients With Neurosensorial Anosmia NCT04957563 | Cristina Gomez Calero | N/A |
| Unknown | Proteomics of Severe Traumatic Brain Injury: A Feasibility Study NCT00522496 | University of Calgary | — |
| Terminated | Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI) NCT00316004 | University of Washington | Phase 3 |
| Active Not Recruiting | Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP) NCT00178659 | The University of Texas Health Science Center, Houston | — |
| Completed | Brain Trauma Outcomes in Nova Scotia Study NCT01225692 | Queen Elizabeth II Health Sciences Centre | N/A |
| Completed | Restoration vs. Compensation in Neurovisual Rehabilitation of Visual Field Defects NCT04043429 | University of Magdeburg | Phase 2 |
| Completed | Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan NCT00134472 | Yamaguchi University Hospital | Phase 3 |