NCT03464175

Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation

Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation: a Randomized Comparative Scintigraphic Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The intention is to enroll a specific sample of intubated patients. To compare the effect of respiratory gas conditioning on lung deposition and considering the well-known influences of lung pathology on lung deposition, intubated patients with healthy lungs will be included. Postoperative neurosurgery ventilated patients respond perfectly to this criteria. A previous study including 17 postoperative neurosurgery patients was performed in 2013 with a perfect collaboration between the ICU and the Department of Neurosurgery and Anesthesiology.

Conditions

• Brain Injuries, Traumatic

Interventions

Type	Name	Description
DEVICE	Aerogen Solo®	Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
DEVICE	Heated-humidified circuit	It will be left on during the transfer and the nebulization in group 1
DEVICE	Heated-humidified circuit	It will be turned off 30 minutes before the nebulization (nebulization ended max 45 minutes after turning off the heated-humidifier).
DEVICE	Dry ventilator circuit specific for aerosol therapy	Streamlined components, specific position for the nebulizer at 30 cm of a V-shaped Y piece
DEVICE	Conventional dry ventilator circuit with HME filter	The nebulizer is placed between the filter and the endotracheal tube.

Timeline

• Start date: 2018-01-22
• Primary completion: 2020-12-15
• Completion: 2020-12-15
• First posted: 2018-03-13
• Last updated: 2022-11-04

Locations

1 site across 1 country: Belgium