| Recruiting | Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak NCT07449208 | Memorial Sloan Kettering Cancer Center | — |
| Recruiting | Leakage Rate of Ileo-COlic Sutured Anastomosis After Right Hemicolectomy NCT07132970 | Aesculap AG | — |
| Recruiting | Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and NCT07351071 | Medtronic - MITG | N/A |
| Recruiting | CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery NCT07464600 | Centre Hospitalier Universitaire, Amiens | N/A |
| Recruiting | Anastomotic Leakage After Colorectal Surgery. NCT07144683 | Minia University | — |
| Recruiting | PARLAR-02 Trial：Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage NCT07036588 | Third Military Medical University | N/A |
| Not Yet Recruiting | Evaluating the Effective and Safe Use of Stream™ Platform NCT06522061 | FluidAI Medical | N/A |
| Enrolling By Invitation | Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences( NCT06862479 | Unidade Local de Saúde Santa Maria | — |
| Recruiting | Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer NCT06097078 | Aesculap AG | — |
| Recruiting | Resumption of Enteral Feeding After Bowel Anastomosis NCT06906289 | Khyber Teaching Hospital | N/A |
| Recruiting | Anastomotic Leakage in Right Colectomy NCT06553261 | Barmherzige Brüder Vienna | — |
| Unknown | Prediction of Anastomotic Complications and Recurrent Laryngeal Nerve Injury Based on Postoperative Early Endo NCT06348381 | Shanghai Chest Hospital | — |
| Active Not Recruiting | Economic Evaluation of Stream™ Platform NCT05994625 | FluidAI Medical | Phase 3 |
| Recruiting | Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer NCT05943444 | Sixth Affiliated Hospital, Sun Yat-sen University | N/A |
| Completed | ICG Anastomosis Control in Colon Surgery NCT05981937 | Azienda Unita Sanitaria Locale di Piacenza | — |
| Recruiting | Evaluation of Colonic Perfusion by Indocyanine Green Angiography During Colorectal Surgery NCT06793280 | University of Roma La Sapienza | N/A |
| Completed | Risk of NSAIDs on Anastomotic Leak for Rectal Surgery NCT06155175 | Third Military Medical University | — |
| Unknown | ECO-LEAK Technique: Early Detection of Colorectal Anastomotic Leakage by Transvaginal Ultrasound NCT05942209 | Instituto de Investigacion Sanitaria La Fe | — |
| Unknown | CRP-guided Transanal Drainage Removal After Rectal Surgery NCT05502354 | Qilu Hospital of Shandong University | N/A |
| Recruiting | A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for A NCT06168669 | Exero Medical Ltd. | N/A |
| Not Yet Recruiting | Quantification of Anastomostic Blood Flow With Fluorescence Imaging in Low Anterior Resection for Rectal Cance NCT05627934 | Odense University Hospital | — |
| Unknown | SURGIcal COmplication and MIcrobiome ChangeS in Colorectal Surgery NCT05779254 | Uzsoki Hospital | — |
| Completed | The Application Value of da Vinci Linear Cutting Stapler SureForm in Robotic Anus Preserving Surgery for Recta NCT05667181 | Nanchang University | N/A |
| Unknown | Enhanced Recovery and Patient Blood Management in Colorectal Surgery NCT05227014 | Ospedale Sandro Pertini, Roma | — |
| Unknown | Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinica NCT05411783 | San Carlo di Nancy Hospital | N/A |
| Unknown | Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small NCT05257863 | Dr. Med Anas Taha | — |
| Unknown | A1Check: the External Validation of a Machine Learning Model Predicting Colorectal Anastomotic Leakage NCT05810207 | Freek Daams | — |
| Unknown | Assessment of Graft Perfusion and Oxygenation for Improved Outcome in Esophageal Cancer Surgery NCT03587532 | University Hospital, Ghent | N/A |
| Recruiting | Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract NCT05606822 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | Quantitative ICG Fluorescence Angiography in Colorectal Surgery NCT05153954 | Zealand University Hospital | — |
| Suspended | The Prediction of Anastomotic Insufficiency Risk After Colorectal Surgery (PANIC) Study NCT04985981 | Michel Adamina, MD | — |
| Unknown | Lateral Invagination of the Colorectal Anastomosis by Double Stapling NCT04553250 | Hospital Clinic of Barcelona | N/A |
| Completed | Microbiota Implementation to Reduce Anastomotic Colorectal Leaks (MIRACLe) NCT05164887 | S.Eugenio Hospital | — |
| Completed | Use of NERv's Inline Device as an Early Diagnostic Method for Postoperative Complications NCT04582708 | FluidAI Medical | Phase 2 |
| Completed | Stratafix vs. Vicryl OAGB / MGB Suture Study NCT04613635 | St. Franziskus Hospital | N/A |
| Completed | Tissue Oxygen Saturation for Esophagectomy NCT04973046 | Shizuoka Cancer Center | — |
| Completed | Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections NCT04550156 | University Hospital, Basel, Switzerland | N/A |
| Unknown | Tisseel® as a Reinforcement of Esophagojejunal Anastomoses NCT03733639 | Germans Trias i Pujol Hospital | Phase 4 |
| Unknown | Predictors of Intestinal Anastomosis Leakage, Application of New Predictors and New Scores NCT04422106 | Mansoura University | N/A |
| Unknown | ESCP Safe Anastomosis proGramme in coLorectal surgEry NCT04270721 | University of Birmingham | N/A |
| Completed | Use of NERv's Inline Device as an Early Diagnostic Method for Anastomotic Leak. NCT04253028 | FluidAI Medical | EARLY_Phase 1 |
| Unknown | Intravenous Human Albumin In Improving Pancreaticoduodenectomy Outcomes NCT04418739 | Universiti Kebangsaan Malaysia Medical Centre | Phase 2 |
| Completed | Endo-Vac-Therapy for Post-Sleeve Gastrectomy Leaks NCT05189574 | Ruhr University of Bochum | — |
| Completed | Colorectal Anastomotic Leak Management NCT05000580 | Surgical Trainees East of England Research Collaborative | — |
| Unknown | Microbiome Analysis in esoPhageal, PancreatIc and Colorectal CaNcer Patients Undergoing Gastrointestinal Surge NCT04189393 | Radboud University Medical Center | — |
| Completed | The Diagnostic Dilemma of Anastomotic Leak in Esophagogastric Surgery NCT05579912 | National University Hospital, Singapore | — |
| Completed | A Retrospective Analysis of Pancreatic Injuries and Treatment Outcomes NCT06227871 | Kern Medical Center | — |
| Completed | Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy NCT03997721 | Copenhagen University Hospital, Hvidovre | — |
| Unknown | Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Re NCT04751149 | Hospital Donostia | N/A |
| Unknown | THREE-row Circular STAPLER in Low Anterior Resection for Rectal Cancer NCT03910699 | Russian Society of Colorectal Surgeons | N/A |
| Completed | Endoscopic Visualisation of Anastomosis in Colorectal Cancer Surgery NCT04738240 | University of Plymouth | N/A |
| Completed | Peripheral Perfusion Index in Acute Surgical Patients NCT03757442 | Hvidovre University Hospital | — |
| Unknown | Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery NCT03771456 | Ospedale C & G Mazzoni | — |
| Unknown | Prediction of Abdominal Complications After GastroEnterological Surgery NCT03828266 | Peking University | — |
| Unknown | Prediction of Intra-abdominal Infectious Complication by Drainage Fluid Analysis NCT03862378 | Peking University | — |
| Unknown | Oral Antibiotic Prophylaxis in Colorectal Surgery NCT03759886 | University of Leipzig | — |
| Completed | Anastomotic Leak Testing in Gastrectomy NCT04292496 | Nanchong Central Hospital | N/A |
| Completed | Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcin NCT03529266 | Sun Yat-sen University | Phase 2 |
| Unknown | C-protein Reactive for the Detection of Anastomotic Leakage After Surgery for Digestive Cancer NCT04133324 | Moroccan Society of Surgery | — |
| Completed | Leukocyte and and Platelet-rich Fibrin Plasma for the Prevention of Anastomotic Leakage in Colorectal Anastomo NCT05264467 | Universidad de Concepcion | Phase 2 / Phase 3 |
| Completed | Role of Procalcitonin, C-Reactive Protein, and WBC Count in Prediction of Colorectal Anastomotic Leak NCT05159024 | Suez Canal University | — |
| Completed | Microbiota-anastomotic Leak Among Colorectal Surgery Patients : Pilot Study NCT03496441 | Centre hospitalier de l'Université de Montréal (CHUM) | — |
| Unknown | Peripheral Perfusion Index, Haemoglobin and Blood Transfusion in Acute Surgical Patients NCT03795467 | Hvidovre University Hospital | — |
| Unknown | Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)? NCT03316677 | Meir Medical Center | N/A |
| Unknown | The Role of Transanal Tube Drainage as A Mean of Prevention of Anastomotic Leakage Anastomotic Leakage NCT03325361 | University of Rome Tor Vergata | N/A |
| Unknown | Early Diagnosis of Anastomotic Leakage After Colorectal Surgery: Italian ColoRectal Anastomotic Leakage Study NCT03560180 | Ospedale C & G Mazzoni | — |
| Completed | Risk Factors Associated With Anastomotic Leak and Perioperative Mortality in Elderly NCT04518384 | Rabin Medical Center | — |
| Unknown | The Impact of Transanal Decompression Tube Placement After Colorectal Anastomosis: A Randomized Trial NCT04890015 | Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta | N/A |
| Completed | MRI Anastomotic Integrity of Pelvic Intestinal Anastomoses NCT04719169 | London North West Healthcare NHS Trust | N/A |
| Completed | Indocyanine Green Fluorescent Imaging in Robotic Assisted Rectosigmoidal Resection; a Multicenter Assessment o NCT04766060 | Odense University Hospital | — |
| Withdrawn | Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Heal NCT02682485 | University of Chicago | Phase 2 |
| Completed | Early Dehiscence Markers in Ovarian Cancer Surgery NCT03131492 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Unknown | Efficacy and Safety of LifeSeal™ Kit for Colorectal Staple Line Sealing NCT02907385 | LifeBond Ltd. | Phase 3 |
| Unknown | Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer NCT02770911 | Fujian Medical University | Phase 3 |
| Unknown | Spanish National Registry of ANAstomotic Leakage in CAncer of the REctum (ANACARE) NCT02634112 | Hospital Universitario La Fe | — |
| Unknown | The Impact of Indocyanine Green-enhanced Fluorescence Imaging on Bowel Transection in Left-sided Colorectal Re NCT02669485 | The University of Hong Kong | N/A |
| Completed | Intracorporeal Vs Extracorporeal Anastomosis in Laparoscopic Right Hemicolectomy NCT03990714 | Hospital Universitario Torrecárdenas | N/A |
| Completed | Human Albumin and Anastomotic Leakage After Gastric Cancer Surgery NCT04490668 | Ruijin Hospital | — |
| Completed | Early Detection of Postoperative Anastomotic Leak by CT NCT03632395 | BIRENDRA KUMAR SAH | — |
| Completed | Endoscopic Evaluation After Esophagectomy NCT02703142 | Nagasaki University | — |
| Completed | Fibrin Sealant in Esophageal Surgery NCT03251040 | Amsterdam UMC, location VUmc | N/A |
| Completed | Predictive Factors for Anastomotic Leakage After Colorectal Surgery NCT02347735 | Maastricht University Medical Center | — |
| Completed | Neutrophil-to-lymphocyte Ratio vs C-reactive Protein as Early Predictors of Anastomotic Leakage After Colorect NCT04673110 | Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba | — |
| Completed | Anastomotic Leakage After Anterior Resection for Rectal Cancer - Predictive Biomarkers and Rectal Blood Flow NCT02401100 | Umeå University | — |
| Completed | Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy NCT02937389 | Nagasaki University | — |
| Completed | Non-invasive Detection of Anastomotic Leakage NCT03203434 | Amsterdam UMC, location VUmc | — |
| Completed | SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition NCT02175979 | Misha D.P. Luyer | N/A |
| Unknown | Effect of Neck Flexion on Esophagogastric Anastomotic Leakage After MIE NCT02418052 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Completed | Decreasing Leak Rate in Colorectal Surgery Using Near Infra-red (NIR) Imaging NCT02459405 | University Hospital, Geneva | Phase 2 |
| Completed | Transanal Inspection and Management of Low ColoRectal Anastomosis Performed With a New Technique NCT02879370 | University of Rome Tor Vergata | N/A |
| Completed | PREDICS Study: PCT Reveals Early Dehiscence in Colorectal Surgery NCT01817647 | University of Roma La Sapienza | — |
| Unknown | Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery NCT00643084 | Hamilton Health Sciences Corporation | N/A |
| Unknown | Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Ana NCT01306851 | Hospital General Universitario Gregorio Marañon | Phase 4 |
| Terminated | Comparative Study of Circular Stapling Instruments NCT00399009 | Uppsala University Hospital | N/A |
| Completed | Does the Management of Anastomotic Leakage After Low Rectal Resection Affect Survival NCT06059924 | Cantonal Hospital of St. Gallen | — |