| Not Yet Recruiting | Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure NCT07463885 | Oslo University Hospital | N/A |
| Not Yet Recruiting | Promoting Change in Practice for Respiratory Failure NCT07519941 | New York University | N/A |
| Not Yet Recruiting | Ultraprotective Lung Ventilation With Respiratory Extracorporeal Life Support for ARDS NCT07516665 | Assistance Publique - Hôpitaux de Paris | N/A |
| Not Yet Recruiting | Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS NCT05241067 | Pharmazz, Inc. | Phase 2 |
| Not Yet Recruiting | Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired P NCT07492875 | ImmunityBio, Inc. | Phase 3 |
| Recruiting | Study of the Immunological Pathophysiological Mechanisms Associated With Acute Respiratory Distress Syndrome NCT07395076 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability NCT07504731 | Zhongda Hospital | — |
| Not Yet Recruiting | Study of Xuanbai Shengmai Decoction in the Treatment of Acute Respiratory Distress Syndrome NCT07528196 | Southeast University, China | Phase 3 |
| Not Yet Recruiting | Machine Learning Prediction of Mortality After Prone Positioning in ARDS NCT07445061 | Shanghai Zhongshan Hospital | — |
| Not Yet Recruiting | Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment NCT07317050 | Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion | Phase 3 |
| Not Yet Recruiting | Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respirat NCT07452952 | University Hospital, Angers | — |
| Not Yet Recruiting | Multi-Omics Integrative Analysis of Serum and Sputum to Uncover Key Determinants of Prognosis in Patients With NCT07380997 | Ruijin Hospital | — |
| Completed | ICU Admission Diagnoses and ICU Mortality NCT07369206 | Ataturk University | — |
| Not Yet Recruiting | Application of Electrical Impedance Tomography in Evaluating Pulmonary Function Improvement After High Lateral NCT07375849 | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | N/A |
| Recruiting | A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantatio NCT07342205 | Shanghai University of Traditional Chinese Medicine | Phase 2 / Phase 3 |
| Enrolling By Invitation | Evaluating Artificial Intelligence-Based Clinical Decision Support for Sepsis and ARDS NCT07025096 | University of Pennsylvania | N/A |
| Recruiting | Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS NCT07248995 | Theodoros Schizodimos | N/A |
| Recruiting | Pulmonary Overdistension Assessment With Electrical Impedance Tomography in Patients With Acute Respiratory Di NCT07090460 | Centre Hospitalier de la côte Basque | — |
| Recruiting | Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predicto NCT07414056 | Ain Shams University | — |
| Recruiting | Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial NCT07123961 | Children's Hospital of Philadelphia | Phase 2 |
| Recruiting | To Evaluate The Safety and Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrom NCT07208591 | Staidson (Beijing) Biopharmaceuticals Co., Ltd | Phase 3 |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab NCT06701656 | PPD Development, LP | Phase 2 |
| Not Yet Recruiting | Clinical Features, Treatments, and Outcomes in Acute Respiratory Distress Syndrome (ARDS-CTO) NCT07186140 | Jee Hwan Ahn | — |
| Not Yet Recruiting | RSPO3/SDC-1 Pathway Dysfunction in Alveolar Repair After ARDS in Older Adults NCT07129330 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab NCT06701682 | PPD Development, LP | Phase 2 |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart NCT06701669 | PPD Development, LP | Phase 2 |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record) NCT06703073 | PPD Development, LP | Phase 2 |
| Recruiting | A Trial of Staff Time With Proned Patients in the ICU Using the 'BathMat' NCT06844617 | Royal United Hospitals Bath NHS Foundation Trust | N/A |
| Recruiting | Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE NCT07432191 | Iconic Solutions By Murcia SL | N/A |
| Recruiting | Mucosal Associated Invariant T Cell During Viral Pneumonia and Acute Respiratory Distress Syndrome NCT06720818 | University Hospital, Tours | — |
| Enrolling By Invitation | Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure NCT06938217 | Institute for Extracorporeal Life Support | N/A |
| Recruiting | Electrical Impedance Tomography-Based Prognostic Model for ARDS NCT06967207 | XiaoJing Zou,MD | — |
| Not Yet Recruiting | Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation NCT06849570 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Comparison of Dynamic Mechanical Power Formula With Geometric Method in Pressure- and Volume-Controlled Ventil NCT07099729 | Başakşehir Çam & Sakura City Hospital | — |
| Recruiting | Intraoperative Paravertebral Block and Postoperative Complications NCT07211529 | Tongji Hospital | N/A |
| Recruiting | Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Ac NCT06694311 | Ricard Mellado Artigas | N/A |
| Recruiting | End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance Tomography-guided PEEP Titration Methods NCT06697717 | XiaoJing Zou,MD | N/A |
| Recruiting | EIT-Guided Ventilator Settings in AHRF NCT06936618 | Mahidol University | N/A |
| Completed | Validation of the Accuracy of a Novel POCT Dry Blood Gas Analyzer in Acute Care Settings NCT06726473 | Zhujiang Hospital | — |
| Completed | The Association Between IL17, Acute Respiratory Distress Syndrome and Acute Respiratory Failure NCT06779942 | Bayer | — |
| Recruiting | Evaluation of the Relevance of Diaphragmatic Stroke Ultrasound for the Etiological Diagnosis of Acute Respirat NCT06650137 | University Hospital, Montpellier | N/A |
| Not Yet Recruiting | Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome NCT06322758 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN) NCT05847517 | Consorcio Centro de Investigación Biomédica en Red (CIBER) | Phase 3 |
| Unknown | Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure NCT06002841 | D'Or Institute for Research and Education | Phase 1 / Phase 2 |
| Completed | An Observational Study to Identify New Health Problems Arising After an Intensive Care Unit Admission in Peopl NCT06272942 | Bayer | — |
| Completed | Prone Duration in COVID-19 ARDS NCT06765759 | Istanbul University - Cerrahpasa | — |
| Completed | Early Prone Positioning and Clinical Outcomes in Non-Intubated Acute Respiratory Distress Syndrome (ARDS) Pati NCT07133022 | Loai Muawiah Zabin | N/A |
| Active Not Recruiting | Study of Safety and Efficacy of ALT-100mAb in Participants With Moderate/Severe ARDS NCT05938036 | Aqualung Therapeutics Corp. | Phase 2 |
| Unknown | An Open-label Study of the Safety and Pharmacokinetics of the TGKP NCT06127381 | Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation | Phase 1 |
| Completed | Safety and Preliminary Efficacy of TISA-818 Injection in Patients With Acute Respiratory Distress Syndrome NCT07319351 | EnliTISA (Shanghai) Pharmaceutical Co., Ltd. | Phase 2 |
| Recruiting | Pirfenidone to Prevent Fibrosis in Ards. NCT05075161 | Università Vita-Salute San Raffaele | Phase 3 |
| Completed | Conventional Versus Automated Bag-based Mechanical Ventilator to Support ARDS Patients NCT06667375 | Fanny Lys Casado Pena | — |
| Terminated | Impact of Intravenous Lidocaine on Clinical Outcomes of Patients With ARDS During COVID-19 Pandemia NCT04609865 | University Hospital, Strasbourg, France | Phase 3 |
| Completed | Cerebral Autoregulation in Pediatric ECMO (ECMOX 2) NCT04548739 | Nantes University Hospital | — |
| Terminated | Evaluation of the Safety and Efficacy of Razuprotafib in Hospitalized Subjects With Coronavirus Disease 2019 NCT04511650 | EyePoint Pharmaceuticals, Inc. | Phase 2 |
| Completed | Clinical and Functional Outcomes of Critically Ill Patients With COVID-19 NCT05024500 | University of Pernambuco | N/A |
| Unknown | Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction NCT04546919 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Recruiting | RecruitmEnt Assessed by eleCtRical Impedance Tomography NCT04460859 | Unity Health Toronto | — |
| Completed | Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure NCT04311697 | APR Applied Pharma Research s.a. | Phase 2 / Phase 3 |
| Unknown | The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients NCT04321616 | Oslo University Hospital | Phase 2 / Phase 3 |
| Terminated | EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients NCT04400643 | Hamilton Medical AG | — |
| Active Not Recruiting | Clinical Evaluation of a Point of Care (POC) Assay to Identify Phenotypes in the Acute Respiratory Distress Sy NCT04009330 | Queen's University, Belfast | — |
| Completed | Pragmatic Investigation of Volume Targeted Ventilation-1 NCT03909854 | Wake Forest University Health Sciences | N/A |
| Completed | Validation of a Semi-automatized Method to Detect Cyclic Hyperinflation on CT-scan in ARDS NCT03870009 | Hospices Civils de Lyon | N/A |
| Unknown | Transfusion of Red Blood Cells for Acute Respiratory Distress Syndrome(ARDS) in Neonates NCT03296059 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Recruiting | Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation NCT02574169 | University Hospital, Toulouse | N/A |
| Completed | Prevalence of Prone Positioning Use in ARDS Patients NCT02842788 | Hospices Civils de Lyon | — |
| Completed | Safety Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS) NCT02425579 | Brigham and Women's Hospital | Phase 1 |
| Completed | Accuracy of the Chest Radiograph for the Diagnosis of Acute Respiratory Distress Syndrome NCT07400445 | Poitiers University Hospital | — |
| Unknown | Surviving ARDS: The Influence of Quality of Care and Individual Patient Characteristics on Quality of Life NCT02637011 | University Hospital Regensburg | — |
| Completed | Does Cricoid Pressure Reduce the Risk of Aspiration? NCT02058004 | Mayo Clinic | N/A |
| Unknown | Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection NCT02095444 | S-Evans Biosciences Co., Ltd. | Phase 1 / Phase 2 |
| Terminated | Trial of an Alternate Mode of Providing Artificial Breaths to Children With Very Severe Pneumonia NCT02167698 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Terminated | Validation of Digital Chest-X-ray (CXR) to Assess Lung Recruitment in ARDS NCT02081105 | Hospices Civils de Lyon | N/A |
| Completed | Validation of the Percentage of Alveolar Fibrocyte as Biomarker During ARDS NCT01854424 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Stratification of the Acute Respiratory Distress Syndrome NCT02288949 | Dr. Negrin University Hospital | — |
| Completed | LIPS-B: Lung Injury Prevention Study With Budesonide and Beta NCT01783821 | Mayo Clinic | Phase 2 |
| Terminated | Lung and Systemic Inflammation in the Critically Ill Patient NCT01906229 | Rigshospitalet, Denmark | — |
| Completed | Energy Load in Patients With Acute Respiratory Distress Syndrome (ARDS) NCT01878552 | Policlinico Hospital | — |
| Unknown | Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients W NCT01763853 | University Hospital, Clermont-Ferrand | Phase 4 |
| Completed | Low Dose Lung CT Scan for Quantitative Analysis in ARDS Patients NCT01926093 | Policlinico Hospital | — |
| Completed | Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome NCT01470703 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation NCT01339533 | Intermountain Health Care, Inc. | Phase 2 |
| Completed | The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory NCT01714583 | Yale University | — |
| Completed | Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome NCT02944279 | Peking University Third Hospital | — |
| Unknown | Trial of Steroids in Pediatric Acute Lung Injury/ARDS NCT01274260 | University of Tennessee | Phase 2 |
| Terminated | The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial NCT01506401 | Canadian Critical Care Trials Group | Phase 3 |
| Completed | Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome NCT01423864 | National Taiwan University Hospital | Phase 2 |