NCT07211529

Intraoperative Paravertebral Block and Postoperative Complications

Perioperative Paravertebral Block Reduces Postoperative Complications in Thoracic Surgery: An Observational Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Tongji Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.

Detailed description

This study is designed as an observational investigation combining both retrospective and prospective components, focusing on patients undergoing thoracic surgery, primarily pulmonary and mediastinal procedures. Retrospective analysis: We will collect data from patients across multiple campuses of Tongji Hospital who previously underwent thoracic surgery with intraoperative paravertebral block. These cases will be retrospectively analyzed to explore the association between paravertebral block and the reduction of postoperative complications. Prospective evaluation: For patients enrolled prospectively, we will collect perioperative biochemical parameters, including MMP3, neutrophils, leukocytes, PCT, CRP, and other relevant regulatory factors. Postoperative outcomes will be assessed by recording cough and pain scores, as well as time to first flatus and defecation at 24 and 48 hours after surgery. In addition, patients will be followed for 30 days to document the incidence of postoperative complications. Clinical correlation: The association between the measured biomarkers and patient outcomes will be systematically evaluated to determine their clinical relevance in predicting prognosis.

Conditions

• Video-assisted Thoracoscopic Surgery (VATS)
• Lung Cancer (Diagnosis)
• Pulmonary Infections
• Respiratory Failure Without Hypercapnia
• Pleural Effusion Due to Another Disorder (Disorder)
• Atelectasis
• Bronchospasm
• Pneumothorax
• Pulmonary Embolism (Diagnosis)
• Bronchopleural Fistula
• Acute Respiratory Distress Syndrome (ARDS)

Interventions

Type	Name	Description
PROCEDURE	Paravertebral Block (PVB)	Participants in this arm will receive a paravertebral nerve block (PVB) performed intraoperatively under ultrasound guidance prior to the thoracic surgical procedure. The block will target the relevant thoracic vertebral levels corresponding to the surgical site. Standard local anesthetic agents will be administered according to institutional protocols. This intervention aims to provide perioperative analgesia, reduce postoperative pain, and potentially decrease the incidence of postoperative complications. All participants will also receive standard intraoperative monitoring and anesthesia management as per routine clinical practice.

Timeline

• Start date: 2025-03-25
• Primary completion: 2028-05-31
• Completion: 2028-12-31
• First posted: 2025-10-08
• Last updated: 2025-10-08

Locations

1 site across 1 country: China