NCT07452835

Transcranial Direct Current Stimulation (tDCS) in Different Psychiatric Disorders

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 320 (actual)
• Sponsor: Menoufia University · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in reducing core symptoms of different psychiatric disorders using validated clinical scales. * To assess response and remission rates. * To evaluate the durability of treatment effects over follow-up. * To examine effects on cognition, daily functioning, and quality of life. * To monitor tolerability and adverse events.

Conditions

• Major Depressive Disorder (MDD)
• SCHIZOPHRENIA 1 (Disorder)
• Obsessive-Compulsive Disorder
• Generalized Anxiety Disorder
• Insomnia

Interventions

Type	Name	Description
DEVICE	tDCS Parameters	Preparation: * Clean scalp with alcohol to reduce impedance. * Apply conductive gel and position electrodes using the 10-20 EEG system. * Use rubber electrodes (5×7 cm) for anodal/cathodal placement. Stimulation: Ramp-up current over 30 sec to avoid discomfort. Monitor for adverse effects (tingling, itching, headache ). Post-Stimulation Assessment: * Evaluate symptom changes using standardized scales (e.g., HAM-D for depression, Y-BOCS for OCD). * Repeat sessions 3-5 times per week.. Safety and Monitoring Adverse Effects: Mild skin irritation, headache (rarely seizures-screen high-risk patients(. Contraindications: Metallic implants, scalp lesions, epilepsy history. Conclusion tDCS is a promising neuromodulatory tool for psychiatric disorders, with varying protocols based on disorder-specific neural targets.

Timeline

• Start date: 2024-01-01
• Primary completion: 2025-06-30
• Completion: 2025-06-30
• First posted: 2026-03-05
• Last updated: 2026-03-06

Locations

1 site across 1 country: Egypt