NCT06609083

Effect of Cannabis on Cigarette Use Behavior

Effect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Cigarette Use

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.

Detailed description

A full-factorial laboratory study will be conducted to determine the impact of acute THC administration on the dose-related motivational, subjective, and physiological effects of combustible cigarettes. This study will employ a double-blind, placebo-controlled, within-subjects crossover design to examine the dose-effects of THC on combustible tobacco use. The study will use multiple active doses of THC and placebo (0, 5, and 30 mg; corresponding to 0, 1, and 6 standard THC unit doses). Participants will be randomized to either smoked or vaporized THC administration using a between-subjects approach to evaluate the effect of congruent versus incongruent routes of THC and tobacco administration on study outcomes.

Conditions

• Cannabis Use
• Tobacco Use
• Cigarette Smoking

Interventions

Type	Name	Description
DRUG	THC 30mg	High dose of THC (30 mg)
DRUG	THC 5mg	Low dose of THC (5 mg)
DRUG	THC 0mg	Placebo dose of THC (0 mg)
DRUG	Cigarette Full Nicotine	Full nicotine cigarette
DRUG	Cigarette Reduced Nicotine	Reduced nicotine cigarette

Timeline

• Start date: 2025-01-22
• Primary completion: 2029-04-01
• Completion: 2029-10-01
• First posted: 2024-09-24
• Last updated: 2026-01-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study