NCT06533904

Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes. The main questions it aims to answer are: Does percutaneous cryoablation improve short and long term pain scores? Does percutaneous cryoablation improve short and long term respiratory mechanics? Does percutaneous cryoablation improve long term quality of life? Does percutaneous cryoablation decrease delirium? Researchers will compare cryoablation to standard multimodal pain therapy to see if this impacts respiratory recovery. Participants will undergo randomization, percutaneous cryoablative procedure, and participate in tests at pre-determined intervals to evaluate their pulmonary recovery.

Conditions

• Trauma
• Rib Fractures
• Chest Wall Disorder
• Respiratory Insufficiency
• Pain, Chest
• Rib Trauma
• Rib Fracture Multiple
• Respiratory Failure
• Respiratory Distress Syndrome

Interventions

Type	Name	Description
PROCEDURE	Percutaneous Cryoablation of Intercostal Nerves	Percutaneous Cryoablation of Intercostal Nerves
OTHER	Multi-modal pain regimen	Standard rib fracture protocol including cyclooxygenase inhibitors, anti-neuropathic, muscle relaxers, short term anesthesia interventions (percutaneous block, epidural)

Timeline

• Start date: 2026-09-01
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2024-08-01
• Last updated: 2026-02-09

Locations

1 site across 1 country: United States