NCT06366399

The Acute T-Rex (Timing of Resistance Exercise) Study

Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 50 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Conditions

• Diabetes Mellitus, Type 2
• Insulin Resistance
• Glucose Intolerance
• Sleep Disturbance
• Overweight or Obesity
• Insulin Sensitivity

Interventions

Type	Name	Description
BEHAVIORAL	Resistance Exercise Timing	1 resistance exercise session consisting of 3 sets, 10 repetitions per set, on 12 different exercises

Timeline

• Start date: 2023-11-15
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-04-15
• Last updated: 2025-04-03

Locations

1 site across 1 country: United States