NCT05985525

Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS)

Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS): Prospective Observational Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Investigation of the feasibility of using near-infrared spectroscopy (NIRS) to monitor microvascular function in critically ill patients.

Detailed description

This is a prospective observational study using non-invasive NIRS for microvascular monitoring in the ICU. The study involves no interventions above standard of care other than the application of the NIRS monitors. NIRS will be applied to skeletal muscle and the brain longitudinally throughout ICU admission. Vital signs are extracted continuously from the ICU monitor and clinical data are recorded from patient records. The broad goals of the study are: 1. Determine the feasibility of longitudinal NIRS monitoring in ICU patients 2. Determine the ability to derive patient-specific microvascular metrics using NIRS 3. Explore the relationship between microvascular metrics and ICU mortality

Conditions

• Sepsis
• Shock
• Critical Illness

Interventions

Type	Name	Description
DEVICE	Skeletal muscle and cerebral NIRS (research device)	NIRS applied on skeletal muscle and brain on days 1, 3, and 8 of ICU admission. Monitoring applied for up to 24hrs on each day.

Timeline

• Start date: 2022-05-27
• Primary completion: 2026-05-31
• Completion: 2026-05-31
• First posted: 2023-08-14
• Last updated: 2025-08-24

Locations

1 site across 1 country: Canada