NCT05906810

Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis

Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis: a Randomized-controlled Clinical Trial.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University of Catania · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis and without any cardiovascular disease.

Detailed description

A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis and without any cardiovascular disease. 90 patients: 30 with peri-implantitis, 30 with peri-implant mucositis and 30 healthy controls and without periodontitis history. All the patients are assessed for clinical, periodontal, blood and non-invasive ultrasound cardiovascular parameters. Measurements are taken before and after initial periodontal treatment in the peri-implantitis/peri-implant mucositis subjects.

Conditions

• Atherosclerosis
• Endothelial Dysfunction
• Peri-Implantitis
• Peri-implant Mucositis

Interventions

Type	Name	Description
PROCEDURE	Non-surgical periodontal treatment	Subgingival biofilm ultrasonic debridement

Timeline

• Start date: 2020-10-05
• Primary completion: 2025-11-20
• Completion: 2025-12-20
• First posted: 2023-06-18
• Last updated: 2025-05-21

Locations

1 site across 1 country: Italy