NCT05651295

A Precision Medicine Approach to Target Engagement for Emotion Regulation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 390 (estimated)
• Sponsor: Matthew Southward · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these studies may identify the mechanisms by which emotion regulation interventions impact emotional functioning and allow for the development of personalized, evidence-based, and scalable emotion regulation interventions.

Conditions

• Emotional Regulation
• Depression
• Anxiety
• Borderline Personality Disorder
• Obsessive-Compulsive Disorder
• Posttraumatic Stress Disorder
• Eating Disorders

Interventions

Type	Name	Description
BEHAVIORAL	Checking the Facts	Checking the Facts is a form of cognitive reappraisal in which participants identify negatively-valenced automatic thoughts and both generate and consider evidence that challenges the validity of those thoughts.
BEHAVIORAL	Opposite to Emotion Action	Opposite to Emotion Action teaches participants to identify their momentary emotion(s), identify the associated behavioral urge(s), and implement a behavior inconsistent with that urge (e.g., approaching a feared stimulus instead of avoiding it).
BEHAVIORAL	Mindfulness of Current Emotions	Mindfulness of Current Emotions teaches participants to nonjudgmentally observe the experience of their emotions, including physiological and cognitive responses to those emotions.

Timeline

• Start date: 2023-09-29
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2022-12-15
• Last updated: 2023-10-02

Locations

1 site across 1 country: United States