NCT05080348

Effectiveness of iPACK on Postoperative Pain From Hamstring Autograft Following ACL Repair

Effectiveness of Preoperative iPACK on Postoperative Pain From Hamstring Autograft for ACL Repair

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Brenton Alexander · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients undergoing ACL repair with hamstring autograft frequently develop significant post operative pain at the hamstring grafting site. This pain is within the distribution of a commonly used regional nerve block, the Interspace between the popliteal artery and capsule of the knee (iPACK). The investigators plan to randomize consenting patients to either receiving a SHAM injection of normal saline or to an interventional group of long acting local anesthetic (Ropivacaine) injected in the popliteal fossa between the popliteal artery and capsule of the knee (iPACK). Both groups of patients will receive standard of care with respect to perioperative pain management, which includes a preoperative adductor canal nerve block and preoperative acetaminophen administration. Dual primary endpoints of postoperative pain scores and mean postoperative opioid use will be retrieved and compared between groups. Additional secondary endpoints will be PACU length of stay, PACU opioid use, POD1 opioids use, and POD1 pain scores (best, worst, average).

Conditions

• Pain, Postoperative
• ACL Injury
• Anesthesia, Local
• Opioid Use

Interventions

Type	Name	Description
PROCEDURE	Ropivacaine iPACK Injection	Injection of 20mL of 0.25% Ropivacaine with 1:400,000 Epinephrine between in the Interspace between the Popliteal Artery and the Capsule of the Knee (iPACK) using ultrasound guidance at the level of the femoral condyles
PROCEDURE	Normal Saline iPACK Injection	Injection of 20mL of 0.9% Normal Saline between in the Interspace between the Popliteal Artery and the Capsule of the Knee (iPACK) using ultrasound guidance at the level of the femoral condyles

Timeline

• Start date: 2021-12-01
• Primary completion: 2022-04-01
• Completion: 2022-05-01
• First posted: 2021-10-15
• Last updated: 2021-10-15