| Not Yet Recruiting | Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction NCT07135687 | Rush University Medical Center | Phase 4 |
| Withdrawn | Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction NCT07115056 | Campbell Clinic | Phase 4 |
| Enrolling By Invitation | Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients NCT07171346 | University of Kansas Medical Center | N/A |
| Recruiting | Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Rec NCT07097077 | Stefano Zaffagnini | N/A |
| Not Yet Recruiting | Validation and Cultural Adaptation of the KOOS-ACL Scale for the Italian Population NCT07386405 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Not Yet Recruiting | Effect of Contralateral NMES on Quadriceps Activation After ACL Injury or Surgery NCT07156734 | Schulthess Klinik | N/A |
| Not Yet Recruiting | Kinesio Taping for the Knee and Ankle: Acute Impact on Balance, Proprioception, and ACL Risk NCT07138573 | Tokat Gaziosmanpasa University | N/A |
| Recruiting | Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction NCT06529692 | University of Michigan | N/A |
| Withdrawn | Internal Bracing Following ACL Reconstruction NCT06289153 | NYU Langone Health | N/A |
| Not Yet Recruiting | MRI Morphology of Femoral Notch in ACL Injury NCT06707285 | Assiut University | — |
| Not Yet Recruiting | HemoNIRS: a Paradigm Shift in the Process of Musculoskeletal Rehabilitation of ACL Injuries in Cyclic Sports A NCT06621355 | Universitat de Lleida | — |
| Not Yet Recruiting | Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft NCT06584838 | Università Vita-Salute San Raffaele | — |
| Recruiting | Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction NCT06529679 | University of Michigan | N/A |
| Recruiting | The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction. NCT06442319 | Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz | N/A |
| Unknown | Ultrasonic Backscatter Imaging for ACL Reconstruction and Shoulder Diseases NCT06361082 | Chang Gung Memorial Hospital | N/A |
| Recruiting | Association Between Neuromuscular Parameters and Functional Assessment After ACL Reconstruction NCT06524869 | University Hospital, Caen | — |
| Enrolling By Invitation | Tourniquet Use in Anterior Cruciate Ligament Repair NCT05931627 | OrthoCarolina Research Institute, Inc. | N/A |
| Completed | Validity of the SHD-LESS Scale After ACL Reconstruction NCT06829849 | University Hospital, Caen | — |
| Recruiting | Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction NCT06311513 | Hospital for Special Surgery, New York | Phase 4 |
| Recruiting | Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle? NCT06235736 | University of Liverpool | — |
| Active Not Recruiting | ACL Reconstruction in Patients Aged 50 Years and Older NCT07387939 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Unknown | Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reco NCT06063915 | Università degli studi di Roma Foro Italico | N/A |
| Completed | Muscular Activations During Eccentric Quadriceps Exercises NCT06162130 | Ordu University | N/A |
| Recruiting | Anterior Cruciate Ligament Study NCT06194682 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Enrolling By Invitation | A New Dual Task Test Method for Football Players NCT05218993 | Hacettepe University | — |
| Recruiting | The Effects of Cognitive Dual-Tasking in Later Stages of Rehabilitation After ACL Reconstruction NCT06206200 | University Ghent | N/A |
| Recruiting | Exploring Prolonged AMR in ACL Reconstructed Patients NCT06430775 | University Ghent | — |
| Active Not Recruiting | Comparison of Semitendinosus and Quadriceps Grafts for Anterior Cruciate Ligament Reconstruction NCT06167343 | Universidad de Granada | N/A |
| Terminated | Knee Split Comparison After ACL Reconstruction NCT04360928 | Rush University Medical Center | N/A |
| Completed | Evaluation of Thermographic Images of the Knee in Patients With Anterior Cruciate Ligament Reconstruction Outc NCT06048991 | Istituto Ortopedico Rizzoli | N/A |
| Completed | Influence of Injury to the Kaplan Fibers in Adult and Pediatric Patients With ACL Injury NCT06002308 | Sichuan Province Orthopetic Hospital | — |
| Recruiting | Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries NCT05747079 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | Evaluation of Anterior Cruciate Ligament Tears Using Diffusion Tractography NCT05806034 | Centre Hospitalier Universitaire, Amiens | N/A |
| Active Not Recruiting | BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft NCT04519801 | Brooke Army Medical Center | N/A |
| Unknown | A Prehab Strengthening Program Prior to ACL Surgery on Lower Limb Structure and Function NCT05374382 | Université de Nantes | N/A |
| Unknown | Post-ACL Reconstruction Rehab UPSCALER App RCT HPUPM NCT05498285 | Hospital Pengajar Universiti Putra Malaysia | N/A |
| Completed | iPACK for Post-op Pain Following ACL Reconstruction NCT05498870 | Medical University of South Carolina | Phase 4 |
| Active Not Recruiting | Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, an NCT05273463 | Mayo Clinic | N/A |
| Unknown | Can a Strength and Technique Intervention Reduce Knee Abduction Moment in Young Female Handball Players NCT05643261 | Norges idrettshøgskole | N/A |
| Recruiting | Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery NCT05488054 | University Hospitals Cleveland Medical Center | N/A |
| Recruiting | Baseline ACL Injury Risk Screening and Normative Data NCT06635668 | Sanford Health | — |
| Recruiting | Mindfulness and ACL Surgery NCT05542563 | University of Wisconsin, Madison | N/A |
| Terminated | Playmaker 3D Printed Knee Extender NCT05878652 | Sanford Health | N/A |
| Recruiting | Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results NCT05391672 | Assiut University | N/A |
| Completed | The Difference Between Using Local and General Dexamethasone in Arthroscopic Anterior Cruciate Ligament Repair NCT06537518 | Benha University | N/A |
| Completed | Evaluation Of Clinical Results And Imaging Of Anterior Cruciate Ligament Reconstruction With Orthopure Xt NCT06091488 | Istituto Ortopedico Rizzoli | N/A |
| Completed | Patients With Acl Injury and Varus Knee Will Undergo Acl Reconstruction Alone, or Combined With High Tibial Os NCT05817084 | Mostafa Hassanein, Msc | N/A |
| Completed | Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon NCT05876013 | St. Olavs Hospital | — |
| Completed | Functional Outcomes of an Accelerated Rehabilitation Protocol for ACL Reconstruction in Amateur Athletes NCT05716529 | Delta University for Science and Technology | N/A |
| Recruiting | The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations. NCT04607538 | Hvidovre University Hospital | — |
| Unknown | The Effect of Accelerated Rehabilitation After Anterior Cruciate Ligament Reconstruction With and Without Sutu NCT05270551 | Assiut University | N/A |
| Unknown | Andrews Return to Sport ACL Score NCT05578248 | Andrews Research & Education Foundation | — |
| Completed | Ultrasound-guided Percutaneous Neuromodulation in Anterior Cruciate Reconstruction NCT05606250 | Universidad Europea de Madrid | N/A |
| Active Not Recruiting | ACL Reconstruction with a New Generation of LARS Artificial Ligament NCT06571955 | MOVMEDIX | N/A |
| Unknown | Effectiveness of iPACK on Postoperative Pain From Hamstring Autograft Following ACL Repair NCT05080348 | Brenton Alexander | N/A |
| Withdrawn | Dietary Protein Intake and Rehabilitation From Anterior Cruciate Ligament Surgery NCT03614351 | Wake Forest University Health Sciences | N/A |
| Unknown | Does Bone Grafting at the Time of Bone-Patellar Tendon-Bone ACL Reconstruction Reduce the Incidence of Post-op NCT04958733 | Hartford Hospital | N/A |
| Unknown | ACL Reconstruction With/Without ALL Reconstruction NCT05461625 | Centre of Postgraduate Medical Education | N/A |
| Not Yet Recruiting | Real-time Sensorimotor Feedback for Injury Prevention in Males Assessed in Virtual Reality NCT04068701 | Children's Hospital Medical Center, Cincinnati | N/A |
| Unknown | ADC in Assessing Femoral Tunnel Position NCT04937517 | Peking University Third Hospital | — |
| Completed | Association Between 4-Month Isokinetic Testing Measures and Second Knee Injuries After Primary Anterior Crucia NCT05897970 | University Hospital, Caen | — |
| Recruiting | The Pediatric ALL Evaluation and Trial NCT04825587 | Ann & Robert H Lurie Children's Hospital of Chicago | N/A |
| Terminated | Assessment Micro-anatomy of the Menisci and Cartilage After Isolated Acute ACL Injury With MRI at 7T NCT05433012 | Balgrist University Hospital | N/A |
| Completed | Double-bundle Versus Single-Bundle Anterior Cruciate Ligament Reconstruction NCT06001164 | Tampere University Hospital | N/A |
| Completed | The Effects of Preoperative Blood Flow Restriction Training in Patients Undergoing ACL Reconstruction NCT06342063 | Women's College Hospital | N/A |
| Unknown | Comparing Adductor Canal Block and Adductor Canal Block-Local Infiltration Analgesia for Post-operative Pain M NCT04721119 | Ottawa Hospital Research Institute | N/A |
| Recruiting | MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MO NCT04572256 | Austin V Stone | EARLY_Phase 1 |
| Unknown | The Effect of Whole Body Vibration After ACLR NCT05254054 | Chinese University of Hong Kong | N/A |
| Completed | Low-Intensity Blood Flow Restriction Training as a Pre-Operative Rehabilitative Modality to Improve Post-Opera NCT04302558 | Mayo Clinic | N/A |
| Recruiting | ACL Reconstruction: Clinical Outcome NCT03441659 | Stefano Zaffagnini | — |
| Completed | Blood Flow Restriction Training (BFR) in an Adolescent Population NCT04285879 | Connecticut Children's Medical Center | N/A |
| Completed | Neuromuscular Training Improves Single-Limb Stability NCT04967937 | Riphah International University | N/A |
| Completed | TeleRehabilitation Following ACL Reconstruction NCT04541940 | NYU Langone Health | N/A |
| Terminated | Continuous Vs Single Shot Block After ACL NCT04101682 | Northwell Health | EARLY_Phase 1 |
| Unknown | FastThread Interference Screws NCT04689061 | Arthrex, Inc. | — |
| Recruiting | Rehabilitation Treatment of Anterior Cruciate Ligament Rupture NCT04408885 | Aarhus University Hospital | — |
| Completed | New Triple Hop Test Quality Assessment Tool NCT04228848 | University of Haifa | N/A |
| Recruiting | Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain NCT03643822 | Women's College Hospital | Phase 4 |
| Unknown | The Effect of Fertilized ACL Technique on Outcomes of ACL Reconstruction in Young Adults NCT04178538 | Marshall University | N/A |
| Unknown | Knee Aspiration and High Definition MRI for ACL Injury NCT04901858 | Cambridge University Hospitals NHS Foundation Trust | N/A |
| Withdrawn | The Effect of Movement Education on Jumping/Landing Quality in High School Athletes NCT04342000 | Hospital for Special Surgery, New York | N/A |
| Completed | Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery NCT04246554 | University Hospitals Cleveland Medical Center | Phase 3 |
| Recruiting | Kinesiophobia After Anterior Cruciate Ligament Reconstruction. NCT05762809 | Tartu University Hospital | N/A |
| Completed | Influence of Combined Double-Bundle ACL Reconstruction With Lateral Retinacular Release to Prevent Patellofemo NCT06004297 | Indonesia University | N/A |
| Unknown | Causes and Patterns of Anterior Cruciate Ligament Injuries Among Egyptian Population NCT03773341 | Assiut University | — |
| Withdrawn | BFR Therapy After ACL Reconstruction NCT03794570 | Steadman Philippon Research Institute | N/A |
| Terminated | Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Recons NCT03497780 | University of Michigan | — |
| Completed | Acupuncture ACL (Anterior Cruciate Ligament) NCT03711734 | Hospital for Special Surgery, New York | N/A |
| Withdrawn | Dynamic ACL Brace: In Vivo Kinematics NCT03670550 | Steadman Philippon Research Institute | N/A |
| Withdrawn | Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury NCT03389685 | NYU Langone Health | Phase 2 |
| Unknown | Multimodal Assessment of Knee Conditions in Rehabilitation NCT03608189 | University of Oulu | — |
| Completed | Nordic Hamstring Exercise After ACL Reconstruction Reconstruction NCT05738200 | University of Toledo | N/A |
| Completed | The Single Leg Squat Test to Evaluate Dynamic Knee Stability After ACLR NCT05294783 | Chinese University of Hong Kong | — |
| Completed | Meniscal Lesions in Return to Sport After Anterior Cruciate Ligament Reconstruction NCT04129827 | University of Bari | — |
| Completed | Opiates Prescribing for Knee Arthroscopies and ACL Reconstruction NCT03876743 | Northwestern University | N/A |
| Completed | Prospective Clinical Results of 3 Different Femoral Fixation in ACL Reconstruction NCT04677218 | Emre Kocazeybek | N/A |
| Completed | Neuroplasticity Associated With Anterior Cruciate Ligament Injury NCT03654495 | Swiss Federal Institute of Technology | N/A |
| Completed | Effect of Biophysical Stimulation on Intraspongious Bone Edema in Anterior Cruciate Ligament Reconstruction NCT04255407 | Istituto Ortopedico Rizzoli | N/A |
| Unknown | The Rehabilitation Effect of Exercise Training in Cruciate Ligament Reconstruction Patients. NCT03359382 | Chang Gung Memorial Hospital | N/A |
| Unknown | Muscle Function and Traumatic Knee Injury in Sports NCT03479775 | Lund University | — |
| Completed | Improving ACL Reconstruction Outcomes: CBPT NCT03243162 | Vanderbilt University Medical Center | N/A |
| Active Not Recruiting | Use of an Osteoconductive Scaffold in ACL-Reconstruction NCT03462823 | Sandro Fucentese | N/A |
| Completed | The Influence of Running to ACL Deficiency NCT03135600 | Guangzhou General Hospital of Guangzhou Military Command | N/A |
| Completed | Factors Affecting the Speed of Recovery After ACL Reconstruction NCT03770806 | University of Washington | N/A |
| Completed | Hamstring Stiffness After Anterior Cruciate Ligament Reconstruction NCT05264597 | University Hospital, Caen | — |
| Completed | Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound NCT04993339 | University of Miami | Phase 3 |
| Terminated | Evaluation of Clinical and Biomechanical Correlation During Return to Sport After Anterior Cruciate Ligament I NCT02686723 | University Hospital, Brest | N/A |
| Completed | Effects of HMB Supplementation on Recovery Following ACL Surgery NCT02602561 | Metabolic Technologies Inc. | N/A |
| Unknown | The Effectiveness of Neuromuscular Training in Healthy and ACL-Injured Adolescent Females NCT02316639 | University of Manitoba | N/A |
| Unknown | Molecular Imaging Assessment of ACL Viability NCT03491046 | University of Cincinnati | N/A |
| Unknown | ACL Reconstruction With Simple and Double Bundle Technique Using Two Different Implants for Graft Fixation NCT04550299 | Vita Care | N/A |
| Completed | Anterior Cruciate Ligament (ACL) Tunnel Widening Comparing All-inside and Interference Screw Fixation Techniqu NCT02052856 | University of British Columbia | — |
| Completed | Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes NCT01034527 | Children's Hospital Medical Center, Cincinnati | N/A |
| Completed | Effectiveness of a Novel Warm-up in Decreasing Risk Factors for ACL Injury in Female Youth Soccer Players NCT01591941 | University of British Columbia | Phase 2 |
| Completed | Subjective Outcomes After ACL Reconstruction With BQT Autograft NCT04901559 | Region Zealand | — |